Nevirapine induced toxic epidermal necrolysis and non-Hodgkin lymphoma in a Human Immunodeficiency Virus positive patient

Budamakuntla, Leelavathy; Loganathan, Eswari; Suryanarayan, Shwetha; Kumar, Abhishek; Sarvajnamurthy, Sacchidanand

doi:10.4103/2229-5178.131096

Cited by 3 publications

(2 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…www.jpadr.com m It affects all ages and both genders but females are more prone to SJS as compared to males (Budamakuntla et al, 2014). Unlike nucleoside analog reverse transcriptase inhibitors, nevirapine does not require phosphorylation to an active metabolite.…”

Section: Discussionmentioning

confidence: 99%

Nevirapine induced Stevens Johnson syndrome

Prajapati¹,

Bala²,

Kansal³

2020

jpadr

View full text Add to dashboard Cite

Introduction: Severe and life-threatening SJS is more common with nevirapine than with other NNRTIs Case presentation: A 56-year-old male patient presented with a complaint of lesions all over the body with a burning sensation for 4 days. He was on an ART regimen, containing zidovudine, lamivudine, and efavirenz combination for 4 years. But patient accidentally started nevirapine and after 10 days he developed maculopapular lesions which were diagnosed as SJS syndrome. There was a history of rash with nevirapine when ART was started initially in 2012. This incident of an adverse event could be assigned a term "probable" according to the WHO-UMC scale for causality assessment as the re-challenge was found positive. Conclusion: Physicians and patients must be aware of this adverse effect on early diagnosis and treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

Nevirapine induced Stevens Johnson syndrome

Prajapati¹,

Bala²,

Kansal³

2020

jpadr

View full text Add to dashboard Cite

show abstract

“…(deoxyribonucleic acid)-dependent DNA polymerase activities by causing a disruption of the enzyme's catalytic site [2]. NVP is notorious to cause adverse drug reactions when compared to other antiretroviral drugs.…”

mentioning

confidence: 99%

A Retrospective Study of Spectrum of Nevirapine Induced Cutaneous Drug Reactions in HIV Positive Patients

Budamakuntla¹,

Challa²,

Basappa³

et al. 2015

UCMS

View full text Add to dashboard Cite

BACKGROUND: Nevirapine, a NNRTI (non-nucleoside reverse transcriptase inhibitor), is most commonly used as a part of the combination therapy for HIV (human immunodeficiency virus) infection because of its efficacy and good tolerability. But it is the major culprit in causing adverse drug reactions ranging from mild maculopapular rash to severe toxic epidermal necrolysis. AIM: To observe the spectrum of adverse cutaneous reactions to Nevirapine. METHODOLOGY: This is a retrospective study from the year 2006-2013. RESULTS: 120 cases presented with adverse cutaneous reactions to NVP (Nevirapine). Out of 120 patients, females outnumbered males (68:52). Majority of them were in the age group of 31-40 years. 63 (52.5%) patients developed maculopapular rash, 37 (30.8%) cases of SJS/TEN (Steven Johnson Syndrome/Toxic epidermal necrolysis), 13 (10.8%) patients developed diffuse erythema, urticarial rash in 3 (2.5%), angioedema in 3 (2.5%), 1 (0.9%) developed serum sickness like reaction. CONCLUSION: Managing HIV infection is a double edged sword, and the benefits of ART have to be balanced against the risks of drug toxicity.

show abstract

Fatal Nevirapine-Induced Toxic Epidermal Necrolysis in a HIV Infected Patient

Paik¹,

Sen

Era³

et al. 2016

JCDR

View full text Add to dashboard Cite

Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are the most Severe Cutaneous Adverse Reactions (SCARs) which mainly caused by exposure to drugs and having significant morbidity and mortality. TEN represents an immunologic reaction to a foreign antigen and is most often caused by drugs. Nevirapine (NVP), a non-nucleoside reverse transcriptase inhibitor (NNRTI) is an important component of Highly Active Antiretroviral Therapy (HAART). It is sometimes associated with life-threatening adverse reactions. Here, we report the fatal case of 72-year-old male who developed TEN secondary to intake of nevirapine. This fatal case report will increase awareness among treating physicians for careful monitoring of patients on NNRTI-based antiretroviral therapy and better counseling of the patient on NVP regimen for early identification and reporting of SCARs so that fatalities due to adverse drug reactions can be prevented with timely intervention.

show abstract

Nevirapine induced toxic epidermal necrolysis and non-Hodgkin lymphoma in a Human Immunodeficiency Virus positive patient

Cited by 3 publications

References 3 publications

Nevirapine induced Stevens Johnson syndrome

Nevirapine induced Stevens Johnson syndrome

A Retrospective Study of Spectrum of Nevirapine Induced Cutaneous Drug Reactions in HIV Positive Patients

Fatal Nevirapine-Induced Toxic Epidermal Necrolysis in a HIV Infected Patient

Contact Info

Product

Resources

About