Never in mitosis gene A-related kinase 6 and aurora kinase A: New gene biomarkers in the conversion from ulcerative colitis to colorectal cancer

Gerçeker, Emre; Boyacioglu, Sedat; Kasap, Elmas; Baykan, Ahmed Ramiz; Yüceyar, Hakan; Yıldırım, Hatice; Ayhan, Semin; Ellidokuz, Ender; Korkmaz, Mehmet

doi:10.3892/or.2015.4187

Cited by 21 publications

(23 citation statements)

References 45 publications

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“…In recent years, altered expression and activity of NEK6 were associated with several types of cancer, such as liver [139], prostate [140], gastric [141][142][143], colorectal [144,145], breast [146], serous epithelial ovarian [147], thyroid [148], and retinoblastoma cancers [149]. In addition, inflammation-based diseases, such as ulcerative colitis, have also been linked to NEK6 [28].…”

Section: Nek6mentioning

confidence: 99%

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Checking NEKs: Overcoming a Bottleneck in Human Diseases

et al. 2020

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In previous years, several kinases, such as phosphoinositide 3-kinase (PI3K), mammalian target of rapamycin (mTOR), and extracellular-signal-regulated kinase (ERK), have been linked to important human diseases, although some kinase families remain neglected in terms of research, hiding their relevance to therapeutic approaches. Here, a review regarding the NEK family is presented, shedding light on important information related to NEKs and human diseases. NEKs are a large group of homologous kinases with related functions and structures that participate in several cellular processes such as the cell cycle, cell division, cilia formation, and the DNA damage response. The review of the literature points to the pivotal participation of NEKs in important human diseases, like different types of cancer, diabetes, ciliopathies and central nervous system related and inflammatory-related diseases. The different known regulatory molecular mechanisms specific to each NEK are also presented, relating to their involvement in different diseases. In addition, important information about NEKs remains to be elucidated and is highlighted in this review, showing the need for other studies and research regarding this kinase family. Therefore, the NEK family represents an important group of kinases with potential applications in the therapy of human diseases.

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Section: Nek6mentioning

confidence: 99%

“…NEK6 was found to be overexpressed in patients with more extensive colon involvement and long-term ulcerative colitis. It was suggested that NEK6 is involved in the early stages of inflammation associated with CRC development in UC patients [28]. Thus, NEK6 could be an early marker of CRC in patients with ulcerative colitis.…”

Section: Nek6mentioning

confidence: 99%

Checking NEKs: Overcoming a Bottleneck in Human Diseases

et al. 2020

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“…16,17 AURKB, a member of the aurora kinase family, is an important diagnostic and prognostic marker involved in the carcinogenesis of colorectal cancers. 18 FOXQ1 is frequently upregulated in colorectal cancers, and FOXQ1 knockdown suppressed cell proliferation and the migration and invasion of colorectal cancers. 19 TOP2A is a potential predictive biomarker for anthracycline and irinotecan treatment in colorectal cancer, and high frequency of gene gains for the TOP1 and TOP2A genes were reported in colorectal cancers.…”

Section: Discussionmentioning

confidence: 99%

“…CDK1 is overexpressed in human colorectal cancers and relevant to the clinical behavior of human colorectal cancers, which was shown by the association between a high ratio of CDK1 nuclear to cytoplasmic expression and poor overall survival and that CDK1 was an independent risk factor for outcome . AURKB, a member of the aurora kinase family, is an important diagnostic and prognostic marker involved in the carcinogenesis of colorectal cancers . FOXQ1 is frequently upregulated in colorectal cancers, and FOXQ1 knockdown suppressed cell proliferation and the migration and invasion of colorectal cancers .…”

Section: Discussionmentioning

confidence: 99%

Screening key lncRNAs for human rectal adenocarcinoma based on lncRNA‐mRNA functional synergistic network

et al. 2019

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Background Rectal adenocarcinoma (READ) is one of the deadliest malignancies, and the molecular mechanisms underlying the initiation and development of READ remain largely unknown. In this study, we aimed to find key long noncoding RNAs (lncRNAs) and mRNAs in READ by RNA sequencing. Methods RNA sequencing was performed to identify differentially expressed mRNAs (DEmRNAs) and lncRNAs (DElncRNAs) between READ and normal tissue. READ‐specific protein‐protein interaction (PPI), DElncRNA‐DEmRNA coexpression, and DElncRNA‐nearby DEmRNA interaction networks were constructed. DEmRNAs and DEmRNAs coexpressed with DElncRNAs were functionally annotated. Results A total of 2113 DEmRNAs and 150 DElncRNAs between READ and normal tissue were identified. The PPI network identified several hub proteins, including CDK1, AURKB, CDC6, FOXQ1, NUF2, and TOP2A. The DElncRNA‐DEmRNA coexpression and DElncRNA‐nearby DEmRNA interaction networks identified some hub lncRNAs, including CCAT1, LOC105374879, GAS5, and B3GALT5‐AS1. The colorectal cancer pathway, the intestinal immune network for IgA production and the p53 signaling pathway were three pathways significantly enriched in DEmRNAs and DEmRNAs coexpressed with DElncRNAs. MSH6 coexpressed with two DElncRNAs (LOC105374879 and CASC15) and BCL2 coexpressed with B3GALT5‐AS1 were significantly enriched in the colorectal cancer signaling pathway. TNFRSF17 coexpressed with B3GALT5‐AS1 was enriched in the intestinal immune network for IgA production. CCNB2 coexpressed with LOC105374879 was enriched in the p53 signaling pathway. Conclusion A total of four DEmRNAs (MSH6, BCL2, TNFRSF17, and CCNB2) and three DElncRNAs (LOC105374879, CASC15, and B3GALT5‐AS1) may be involved in the pathogenesis of READ; this data may contribute to understanding the mechanisms of READ and the development of therapeutic strategies for READ.

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“…Drinking and smoking are also risk factors. Except the environmental factors, patients with familial adenomatous polyposis or ulcerative colitis often progress to colon carcinoma. Furthermore, a hereditary predisposition has also been reported .…”

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confidence: 99%