Neutrophils Usher Monocytes Into Sites of Inflammation

Świrski, Filip K.; Robbins, Clinton S.

doi:10.1161/circresaha.113.300867

Cited by 29 publications

(19 citation statements)

References 8 publications

(9 reference statements)

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“…37 Conversely, a positive association was found with lymphocytes, which are involved in the immune reactivity and have been previously shown to be positively stimulated by some dietary components such as antioxidants. 38 Moreover, we found an inverse association between the MD and the NLR ratio, which has been recently reported as a prognostic marker for CVD, 28 further confirming that this dietary pattern is mainly effective on the inflammatory components of WBCs.…”

Section: Discussionmentioning

confidence: 93%

Adherence to the Mediterranean diet is associated with lower platelet and leukocyte counts: results from the Moli-sani study

Bonaccio

Castelnuovo

Curtis

et al. 2014

Blood

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Key Points• Adherence to a Mediterranean diet is associated with reduced platelet and leukocyte counts.• The observed associations are partially explained by the high dietary fiber and antioxidant content of the Mediterranean diet.Platelet (PLT) and white blood cell (WBC) counts are 2 markers of inflammation and have been linked to the risk for cerebrovascular and coronary heart disease. A Mediterranean diet (MD) has been associated with reduced inflammation and mortality for major chronic diseases. We aimed at evaluating the association between the MD and both PLT and WBC counts. This cross-sectional analysis in a population-based cohort study included 14 586 healthy Italian citizens enrolled within the Moli-sani study. Adherence to MD was appraised by either the MD Score (MDS) or the Italian Mediterranean Index (IMI). PLT and WBC counts were both inversely related to MD adherence (MDS: P < .0001 and P 5 .008, respectively). As compared with those with poorer MD adherence, subjects with greater adherence had both reduced odds of being in the highest PLT-count group (MDS: odds ratio 5 0.50; 95% confidence interval, 0.31-0.80) and increased odds of being in the lowest WBC-count group (IMI: odds ratio 5 1.41; 95% confidence interval, 1.07-1.86). The association between WBC count and MDS disappeared when further adjusted for PLT count, whereas the association between PLT count and the MD was not affected by adjustment for WBCs. Food antioxidant and dietary fiber content modified the inverse association between MDS and WBC count and partially accounted for the association with PLTs.

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Section: Discussionmentioning

confidence: 93%

Adherence to the Mediterranean diet is associated with lower platelet and leukocyte counts: results from the Moli-sani study

Bonaccio

Castelnuovo

Curtis

et al. 2014

Blood

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“…Future studies will need to determine whether those processes are linked and how Nr4a1 influences other cells in MI, such as cardiomyocytes, endothelial cells, and T cells 39–42 . It will also be important to discern whether additional mechanisms, perhaps mediated by neutrophils, contribute to the heightened influx of monocytes 43 .…”

Section: Discussionmentioning

confidence: 99%

Ly-6C ^high Monocytes Depend on Nr4a1 to Balance Both Inflammatory and Reparative Phases in the Infarcted Myocardium

Hilgendorf

Gerhardt

Tan

et al. 2014

Circulation Research

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465

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Rationale Healing after myocardial infarction (MI) involves the biphasic accumulation of inflammatory Ly-6Chigh and reparative Ly-6Clow monocytes/macrophages (Mo/MΦ). According to one model, Mo/MΦ heterogeneity in the heart originates in the blood and involves the sequential recruitment of distinct monocyte subsets that differentiate to distinct macrophages. Alternatively, heterogeneity may arise in tissue from one circulating subset via local macrophage differentiation and polarization. The orphan nuclear hormone receptor, Nr4a1, is essential to Ly-6Clow monocyte production but dispensable to Ly-6Clow macrophage differentiation; dependence on Nr4a1 can thus discriminate between systemic and local origins of macrophage heterogeneity. Objective This study tested the role of Nr4a1 in MI in the context of the two Mo/MΦ accumulation scenarios. Methods and Results We show that Ly-6Chigh monocytes infiltrate the infarcted myocardium and, unlike Ly-6Clow monocytes, differentiate to cardiac macrophages. In the early, inflammatory phase of acute myocardial ischemic injury, Ly-6Chigh monocytes accrue in response to a brief Ccl2 burst. In the second, reparative phase, accumulated Ly-6Chigh monocytes give rise to reparative Ly-6Clow F4/80high macrophages that proliferate locally. In the absence of Nr4a1, Ly-6Chigh monocytes express heightened levels of Ccr2 on their surface, avidly infiltrate the myocardium, and differentiate to abnormally inflammatory macrophages, which results in defective healing and compromised heart function. Conclusions Ly-6Chigh monocytes orchestrate both inflammatory and reparative phases during MI and depend on Nr4a1 to limit their influx and inflammatory cytokine expression.

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“…Elevated levels of IL-1β in these hematopoietic compartments stimulate the accelerated rate of myelopoesis required to support the high leukocyte demand. Neutrophils are the first immune cells to infiltrate the myocardium, and initiate monocyte recruitment through endothelial activation, in a process partially mediated by cathelicidins (59). Recruitment of Ly6C hi inflammatory monocytes is the cornerstone of myocardial recovery.…”

Section: Concluding Summary and Future Directionsmentioning

confidence: 99%

Innate Immune Mechanisms in Myocardial Infarction - An Update

Mareş

Marinković

Cotoi

et al. 2018

Revista Romana De Medicina De Laborator

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Neutrophils Usher Monocytes Into Sites of Inflammation

Cited by 29 publications

References 8 publications

Adherence to the Mediterranean diet is associated with lower platelet and leukocyte counts: results from the Moli-sani study

Adherence to the Mediterranean diet is associated with lower platelet and leukocyte counts: results from the Moli-sani study

Ly-6C ^high Monocytes Depend on Nr4a1 to Balance Both Inflammatory and Reparative Phases in the Infarcted Myocardium

Innate Immune Mechanisms in Myocardial Infarction - An Update

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Neutrophils Usher Monocytes Into Sites of Inflammation

Cited by 29 publications

References 8 publications

Adherence to the Mediterranean diet is associated with lower platelet and leukocyte counts: results from the Moli-sani study

Adherence to the Mediterranean diet is associated with lower platelet and leukocyte counts: results from the Moli-sani study

Ly-6C high Monocytes Depend on Nr4a1 to Balance Both Inflammatory and Reparative Phases in the Infarcted Myocardium

Innate Immune Mechanisms in Myocardial Infarction - An Update

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Ly-6C ^high Monocytes Depend on Nr4a1 to Balance Both Inflammatory and Reparative Phases in the Infarcted Myocardium