Neutrophils

Shah, Binita; Burg, Nathalie; Pillinger, Michael H.

doi:10.1016/b978-0-323-31696-5.00011-5

Cited by 11 publications

(10 citation statements)

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“…In vivo, the effect of G-CSF administration could be represented by a temporary fall (1–2 h) in peripheric neutrophiles number (increased margination effect) and followed by an increased number secondary to the release from the place of ‘production’—the bone marrow of mature granulocytes [ 5 , 6 ]. At the bone marrow level, G-CSF will stimulate the proliferation of neutrophils precursors, differentiation of pluripotent stem cells from bone marrow on the myeloid line, and release through sinusoids into the bloodstream [ 6 , 7 ]. In the bone marrow, the myeloid line consists of two-compartments: proliferative (precursors of granulocytes) and non-proliferative pool (mature cells ‘stock’) [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

“…In the bone marrow, the myeloid line consists of two-compartments: proliferative (precursors of granulocytes) and non-proliferative pool (mature cells ‘stock’) [ 8 ]. The total duration for neutrophiles development from initial pluripotent stem cell is approximately 14 days, with several stages of maturation from myeloblasts, promyelocyte, metamyelocytes, and mature neutrophil [ 7 ]. Promyelocyte is a dedicated precursor for neutrophils.…”

Section: Discussionmentioning

confidence: 99%

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Continuous Intravenous Administration of Granulocyte-Colony-Stimulating Factors—A Breakthrough in the Treatment of Cancer Patients with Febrile Neutropenia

et al. 2021

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(1) Background: Febrile neutropenia (FN) remains one of the most challenging problems in medical oncology and is a very severe side effect of chemotherapy. Its late consequences, when it is recurrent or of a severe grade, are dose reduction and therapy delays. Current guidelines allow the administration of granulocyte-colony-stimulating factors (G-CSF) for profound FN (except for the case when a pegylated form of G-CSF is administrated with prophylactic intention) in addition to antibiotics and supportive care. (2) Methods: This is a prospective study that included 96 patients with confirmed malignancy, treated with chemotherapy, who developed FN during their oncological therapy, and were hospitalized. They received standard treatment plus a dose of G-CSF of 16 µg/Kg/day IV continuous infusion. (3) Results: The gender distribution was almost symmetrical: Male patients made up 48.96% and 51.04% were female patients, with no significance on recovery from FN (p = 1.00). The patients who received prophylactic G-CSF made up 20.21%, but this was not a predictive or prognostic factor for the recovery time from aplasia (p = 0.34). The median chemotherapy line where patients with FN were included was two and the number of previous chemotherapy cycles before FN was three. The median serological number of neutrophils (PMN) was 450/mm3 and leucocytes (WBC) 1875/mm3 at the time of FN. Ten patients possess PMN less than 100/mm3. The median time to recovery was 25.5 h for 96 included patients, with one failure in which the patient possessed grade 5 FN. Predictive factors for shorter recovery time were lower levels of C reactive protein (p < 0.001) and procalcitonin (p = 0.002) upon hospital admission and higher WBC (p = 0.006) and PMN (p < 0.001) at the time of the provoking cycle of chemotherapy for FN. The best chance for a shorter duration of FN was a short history of chemotherapy regarding the number of cycles) (p < 0.0001). (4) Conclusions: Continuous IV administration of G-CSF could be an alternative salvage treatment for patients with profound febrile neutropenia, with a very fast recovery time for neutrophiles.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Continuous Intravenous Administration of Granulocyte-Colony-Stimulating Factors—A Breakthrough in the Treatment of Cancer Patients with Febrile Neutropenia

et al. 2021

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“…Factores de RCV convencionales (como tabaquismo, obesidad, diabetes, hipertensión y dislipidemia) se asocian con altos niveles de hs-PCR. Los niveles también pueden aumentar por causas psicosociales, por ejemplo, el estrés crónico y la depresión (9). Ridker et al N Engl J of Med 1997;336: 973-979. Se sabe, por ejemplo, que la evaluación de riesgo por la escala de Framingham (EF) tiene tendencia a sobrestimar en forma sistemática el riesgo para EC en poblaciones como la chilena, que comparativamente a la de Estados Unidos tiene una incidencia más baja de infarto agudo al miocardio (IAM) (5,6).…”

Section: Proteína C Reactiva De Alta Sensibilidad (Hs-pcr)unclassified

Marcadores Cardiacos Y Riesgo Cardiovascular

Doron

Múñoz

2015

Revista Médica Clínica Las Condes

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RESUMENLa identificación del riesgo que un individuo o una población tienen de presentar un evento cardiovascular y la posibilidad de intervenir oportunamente para evitarlo, constituye el fundamento que ha propiciado la investigación de marcadores cardiacos y su potencial de predicción de riesgo cardiovascular. La mortalidad por causa cardiovascular es la primera causa de muerte en el mundo desarrollado y también en Chile, por lo que los esfuerzos de identificación acuciosa y de correcta clasificación de riesgo de los individuos o población permiten una eficiente focalización de los esfuerzos por disminuir los eventos cardiovasculares. En este artículo se revisan distintos marcadores cardiacos (proteína C reactiva ultra sensible, score calcio coronario, péptido natriurético y troponina ultrasensible) y las evidencias que apoyan o desalientan su uso para una adecuada evaluación de riesgo cardiovascular.Palabras clave: Aterosclerosis, epidemiologia, enfermedad coronaria, proteínas. SUMMARY The identification of the risk that an individual or populations have of developing a cardiovascular event, and the opportunity for an early intervention to avoid it, is the foundation that has motivated the research in cardiac markers and their potential in cardiovascular risk prediction.Cardiovascular disease is the leading cause of mortality in Chile and the developed world, therefore, a precise identification and a correct risk classification of the individuals or a population allow a more focalized and efficient effort to decrease cardiovascular events. In this paper, different cardiac markers are reviewed, high sensitive C reactive protein, coronary calcium score, brain natriuretic peptide Artículo recibido: 31-12-2014 Artículo aprobado para publicación: 28-01-2015 and high sensitive troponin among others, and the evidence to support or discourage their use for an adequate assessment of cardiovascular risk.

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“…Neutrophils are the most abundant cell type in human blood, representing 50-70% of leukocytes in humans throughout life [5]. They are a type of “granulocytes”, produced in the bone marrow and released into circulation for immune surveillance, representing a first line-of-defense against infections [6, 7]. Neutrophils perform key immune functions, including the production/release of antimicrobial granules and of “Neutrophil Extracellular Traps” [NETs] [6, 8], composed of extruded chromatin, proteases, and antimicrobial peptides.…”

Section: Introductionmentioning

confidence: 99%

Sex-dimorphic expression of extracellular matrix genes in mouse bone marrow neutrophils

McGill

Ewald

Benayoun

2023

Preprint

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The mammalian innate immune system is sex-dimorphic. Neutrophils are the most abundant leukocyte in humans and represent innate immunity's first line of defense. We previously found that primary mouse bone marrow neutrophils show widespread sex-dimorphism throughout life, including at the transcriptional level. Extracellular matrix [ECM]-related terms were observed among the top sex-dimorphic genes. Since the ECM is emerging as an important regulator of innate immune responses, we sought to further investigate the transcriptomic profile of primary mouse bone marrow neutrophils at both the bulk and single-cell level to understand how biological sex may influence ECM component expression in neutrophils throughout life. Here, using curated gene lists of ECM components and unbiased weighted gene co-expression network analysis [WGCNA], we find that multiple ECM-related gene sets show widespread female-bias in expression in primary mouse neutrophils. Since many immune-related diseases (e.g., rheumatoid arthritis) are more prevalent in females, our work may provide insights into the pathogenesis of sex-dimorphic inflammatory diseases.

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Neutrophils

Cited by 11 publications

References 122 publications

Continuous Intravenous Administration of Granulocyte-Colony-Stimulating Factors—A Breakthrough in the Treatment of Cancer Patients with Febrile Neutropenia

Continuous Intravenous Administration of Granulocyte-Colony-Stimulating Factors—A Breakthrough in the Treatment of Cancer Patients with Febrile Neutropenia

Marcadores Cardiacos Y Riesgo Cardiovascular

Sex-dimorphic expression of extracellular matrix genes in mouse bone marrow neutrophils

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