Neutrophils of Centenarians Show Function Levels Similar to Those of Young Adults

Alonso-Fernández, Patricia; Puerto, Marta; Maté, Ianire; Ribera, Josep‐Marǐa; Fuente, Mónica De la

doi:10.1111/j.1532-5415.2008.02018.x

Cited by 75 publications

(60 citation statements)

References 46 publications

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“…1 ). In fact, human centenarians show levels of oxidative stress and function similar to those in adults (30-year-old) and lower oxidative stress and better function than those found in 70-year-old subjects in their immune cells [4] . Similar finding have been obtained on very long-lived mice [5] .…”

Section: Neuroendocrine-immune Communication In Aging: Role Of the Immentioning

confidence: 83%

Models of Aging of Neuroimmunomodulation: Strategies for Its Improvement

Fuente¹,

Giménez‐Llort²

2010

Neuroimmunomodulation

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Communication between the nervous and the immune systems suffers impairment with aging, which explains the altered homeostasis and the resulting increase of morbidity and mortality in aged subjects. In humans, rats and specially in mice, we have proposed several models to study this fact. The established models of premature aging have been mice and humans with poor response to stress and anxiety versus subjects of the same chronological age without that characteristic, isolation, males versus females, menopausal models (in rodents after ovariectomy) and obesity. In all cases, the prematurely aged animals suffer an alteration of the nervous system (shown by behavioral tests) and immunosenescence as well as oxidative and inflammatory stress, which is followed by early mortality. In addition, in the above-mentioned models and in normal chronological aging, we have observed the effect of several lifestyle strategies, such as ingestion of adequate amounts of antioxidants, performance of moderate physical exercise, and different kinds of environmental enrichment, which improve the function of the immune cells and their redox state as well as animal behavior. Therefore, they retard the aging process and seem to increase the longevity of the individuals.

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Section: Neuroendocrine-immune Communication In Aging: Role Of the Immentioning

confidence: 83%

Models of Aging of Neuroimmunomodulation: Strategies for Its Improvement

Fuente¹,

Giménez‐Llort²

2010

Neuroimmunomodulation

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“…The reason for the present Wnding is not known. It is possible that the older subjects have more Wrmly attached leukocytes to the blood vessels than the younger ones (Corberand et al 1981;Alonso-Fernandez et al 2008). Blood GH response to the exercise was clearly and signiWcantly larger (both relatively and absolutely) in the young than in the older with a subpopulation from which it was measured at post 21 weeks (n = 5 in the young and n = 9 in the older) (manuscript in preparation).…”

Section: Discussionmentioning

confidence: 98%

Effects of resistance exercise and protein ingestion on blood leukocytes and platelets in young and older men

et al. 2010

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This study investigated, in a multi-experiment design, the acute effects of milk protein ingestion, aging [50 young (approximately 26 years) vs. 45 older (approximately 61 years) men] and training state for the blood leukocyte and platelet responses acutely after a single bout of resistance exercise (RE). Moreover, basal effects of 21 weeks of resistance training (RT) were examined. The single bout of RE rapidly increased all blood leukocytes and platelets (P < 0.05). Protein ingestion before or before and after the RE bout did not have an effect on this response. However, younger men had a larger immediate exercise-induced response in leukocytes and platelets than older men. Basal fasting levels of leukocytes and platelets remained unchanged after 21 weeks of RT and this RT period did not change the acute RE-induced leukocyte and platelet response. The long-term RT was, however, able to slightly increase blood hematocrit. Blood platelet counts were consistently higher in the younger men when compared to the older men. Blood lymphopenia occurred only after a larger volume of exercise. In conclusion, the acute increase in blood leukocytes and platelets may be smaller in the older as when compared to the younger men. However, the number of immune cells and thus probably their function may not be affected by milk protein ingestion or months of resistance training.

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“…Nevertheless, the pronounced age-related decrease in T-cell functions is evident, specially in the T-cell helper, which affects humoral immunity and causes an impaired B-cell function (2,7) . In the cells of innate immunity, the phagocytic cells show functions that decrease with ageing and others that are over activated (2,(11)(12)(13) , whereas the anti-tumoral activity of natural killer (NK) cells, in most of the work, shows an age-related decrease (2,11,14) . In addition, it has been demonstrated that the competence of the immune system is an excellent marker of health (2,4,8,15,16) and several age-related changes in immune functions, such as low T-cell proliferative responses, IL-2 secretion and NK cell cytotoxicity, have been linked to longevity (2,15,16) .…”

Section: Proceedings Of the Nutrition Societymentioning

confidence: 99%

“…This can be tested on both humans (centenarians) and experimental animals, such as extremely long-lived mice. While biologically older animals showing the immune competence levels characteristic of chronologically older individuals have been found to die prematurely (2,17) , centenarians and long-lived mice exhibit a high degree of preservation of several immune functions, which may be related to their ability to reach a very advanced age in a healthy condition (2,13,(18)(19)(20) . All the above results confirm that the immune system is a good marker of biological age and a predictor of longevity.…”

Section: Proceedings Of the Nutrition Societymentioning

confidence: 99%

Murine models of premature ageing for the study of diet-induced immune changes: improvement of leucocyte functions in two strains of old prematurely ageing mice by dietary supplementation with sulphur-containing antioxidants

Fuente

2010

Proc. Nutr. Soc.

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Several immune functions are markers of health, biological age and predictors of longevity. A chronic oxidative and inflammatory state is the main cause of ageing and the immune system is involved in the rate of ageing. Thus, several murine models of premature ageing have been proposed owing to their early immunosenescence and oxidative stress, such as ovariectomised rats and mice, obese rats and anxious mice. In the last model, the most extensively studied by us, mice showing anxiety have an aged immune function and redox status as well as a shorter longevity in comparison with animals without anxiety of the same chronological age, being denominated prematurely ageing mice. A confirmation of the above is that the administration of diets supplemented with antioxidants improves the redox status and immune functions and increases the longevity of prematurely ageing mice. Antioxidant precursors of glutathione such as thioproline or N-acetylcysteine, which have a relevant role in ageing, have been the most widely investigated in adult prematurely ageing mice in our laboratory. In the present work, we have studied the effects of the ingestion for 5 weeks of a diet supplemented with 0 . 1 % (w/w) thioproline + N-acetylcysteine on several functions of leucocytes from chronological old (69-73 weeks of age) prematurely ageing mice of two strains (Swiss and BALB/c). The results show an improvement of the immune functions, with their values becoming closer to those in adult animals (24°2 weeks). Thus, an adequate nutrition with antioxidants, even in aged subjects, could be a good strategy to retard ageing.

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Neutrophils of Centenarians Show Function Levels Similar to Those of Young Adults

Abstract: Progressive impairment of the immune system accompanies aging. The better preservation of function and antioxidant systems in the neutrophils of centenarians could play a key role in the longevity of these subjects.

Cited by 75 publications

References 46 publications

Models of Aging of Neuroimmunomodulation: Strategies for Its Improvement

Models of Aging of Neuroimmunomodulation: Strategies for Its Improvement

Effects of resistance exercise and protein ingestion on blood leukocytes and platelets in young and older men

Murine models of premature ageing for the study of diet-induced immune changes: improvement of leucocyte functions in two strains of old prematurely ageing mice by dietary supplementation with sulphur-containing antioxidants

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