Neutrophils: Novel key players in Rheumatoid Arthritis. Current and future therapeutic targets

Cecchi, Irene; Rosa, I. Arias de la; Menegatti, Elisa; Roccatello, Dario; Collantes-Estévez, Eduardo; López‐Pedrera, Chary; Barbarroja, Nuria

doi:10.1016/j.autrev.2018.06.006

Cited by 100 publications

(70 citation statements)

References 146 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…8c). The role of neutrophil migration in many different inflammation-related pathologies is of increasing interest (Brubaker et al 2013;Cecchi et al 2018); there is strong evidence in the biological literature that a reduction in the rate of neutrophil chemotaxis occurs under trauma and ageing and results in an otherwise healthy inflammatory response being pushed into a persistent inflammatory response (Sapey et al 2014). Indeed, neutrophil migration is now thought to be an attractive therapeutic target for diseases such as chronic obstructive pulmonary disease, a chronic lung disease characterised by aberrant neutrophil migration (Sapey et al 2011;Jasper et al 2019).…”

Section: Discussionmentioning

confidence: 99%

Mechanisms and Points of Control in the Spread of Inflammation: A Mathematical Investigation

et al. 2020

View full text Add to dashboard Cite

Understanding the mechanisms that control the body's response to inflammation is of key importance, due to its involvement in myriad medical conditions, including cancer, arthritis, Alzheimer's disease and asthma. While resolving inflammation has historically been considered a passive process, since the turn of the century the hunt for novel therapeutic interventions has begun to focus upon active manipulation of constituent mechanisms, particularly involving the roles of apoptosing neutrophils, phagocytosing macrophages and anti-inflammatory mediators. Moreover, there is growing interest in how inflammatory damage can spread spatially due to the motility of inflammatory mediators and immune cells. For example, impaired neutrophil chemotaxis is implicated in causing chronic inflammation under trauma and in ageing, while neutrophil migration is an attractive therapeutic target in ailments such as chronic obstructive pulmonary disease. We extend an existing homogeneous model that captures interactions between inflammatory mediators, neutrophils and macrophages to incorporate spatial behaviour. Through bifurcation analysis and numerical simulation, we show that spatially inhomogeneous outcomes can present close to the switch from bistability to guaranteed resolution in the corresponding homogeneous model. Finally, we show how aberrant spatial mechanisms can play a role in the failure of inflammation to resolve and discuss our results within the broader context of seeking novel inflammatory treatments.

show abstract

Section: Discussionmentioning

confidence: 99%

Mechanisms and Points of Control in the Spread of Inflammation: A Mathematical Investigation

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Rheumatoid arthritis (RA) is a T-cell and autoantibody-mediated autoimmune disease which results in joint damage and destruction of cartilage. Neutrophils are prominent in the pathogenesis of RA, as demonstrated in numerous RA mouse models as well as human disease [ 105 ]. In two prominent mouse models of RA, namely K/BxN antibody-mediated arthritis and collagen-induced arthritis, a specific role for MPO was indicated by reduced disease severity in MPO −/− mice [ 106 , 107 , 108 , 109 ].…”

Section: Scn − In Diseasesmentioning

confidence: 99%

The Role of Thiocyanate in Modulating Myeloperoxidase Activity during Disease

Gabriel

Liu

Schroder

et al. 2020

IJMS

View full text Add to dashboard Cite

Thiocyanate (SCN−) is a pseudohalide anion omnipresent across mammals and is particularly concentrated in secretions within the oral cavity, digestive tract and airway. Thiocyanate can outcompete chlorine anions and other halides (F−, Br−, I−) as substrates for myeloperoxidase by undergoing two-electron oxidation with hydrogen peroxide. This forms their respective hypohalous acids (HOX where X− = halides) and in the case of thiocyanate, hypothiocyanous acid (HOSCN), which is also a bactericidal oxidative species involved in the regulation of commensal and pathogenic microflora. Disease may dysregulate redox processes and cause imbalances in the oxidative profile, where typically favoured oxidative species, such as hypochlorous acid (HOCl), result in an overabundance of chlorinated protein residues. As such, the pharmacological capacity of thiocyanate has been recently investigated for its ability to modulate myeloperoxidase activity for HOSCN, a less potent species relative to HOCl, although outcomes vary significantly across different disease models. To date, most studies have focused on therapeutic effects in respiratory and cardiovascular animal models. However, we note other conditions such as rheumatic arthritis where SCN− administration may worsen patient outcomes. Here, we discuss the pathophysiological role of SCN− in diseases where MPO is implicated.

show abstract

“…netosis), tj. programowanej genetycznie śmierci z równoczesną prezentacją antygenów limfocytom [23]. Interesującym sposobem oceny toczącego się stanu zapalnego jest określenie stosunku neutrofi lów do limfocytów (ang.…”

Section: Wynikiunclassified

Obraz cytoimmunologiczny płynu stawowego w reumatoidalnym zapaleniu stawów. Wstępna ocena wpływu leczenia metotreksatem i metyloprednizolonem

Wędrowska¹,

Libura²,

Chmielarski³

et al. 2018

PiS

View full text Add to dashboard Cite

Neutrophils: Novel key players in Rheumatoid Arthritis. Current and future therapeutic targets

Cited by 100 publications

References 146 publications

Mechanisms and Points of Control in the Spread of Inflammation: A Mathematical Investigation

Mechanisms and Points of Control in the Spread of Inflammation: A Mathematical Investigation

The Role of Thiocyanate in Modulating Myeloperoxidase Activity during Disease

Obraz cytoimmunologiczny płynu stawowego w reumatoidalnym zapaleniu stawów. Wstępna ocena wpływu leczenia metotreksatem i metyloprednizolonem

Contact Info

Product

Resources

About