Neutrophils in cancer—unresolved questions

Ng, Melissa; Tan, Leonard; Wang, Quanbo; Mackay, Charles R.; Ng, Lai Guan

doi:10.1007/s11427-020-1853-4

Cited by 9 publications

(3 citation statements)

References 120 publications

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“…As a type of white blood cells, they exist in the form of nuclear, and rank the top in terms of importance and quantity in the blood circulating. They are usually the rst responders under autoimmune physiological or pathological conditions of sterile injury, infection and in ammation, and act as the rst line of defense to protect the host from tissue injury and infection [40,41]. Tumor-associated neutrophils (TAN) accumulate in local areas and can be triggered by external stimuli in the tumor microenvironment (TME), switching between an antitumorigenic phenotype and a pro-tumorigenic phenotype [42].…”

Section: Discussionmentioning

confidence: 99%

The Prognostic Value of Prognostic Nutritional Index in Patients With Advanced or Metastatic Gastric Cancer Treated With Immunotherapy

Pan¹,

Dai²

2023

Preprint

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Background In recent years, the therapeutic effect of monoclonal antibody against programmed cell death protein-1 (PD-1) monotherapy or combined chemotherapy in patients with locally advanced or metastatic gastric or gastroesophageal junction (G/GEJ) cancer has been confirmed by many studies. A number of clinical studies of anti-PD-1 antibody combined with chemotherapy in the perioperative treatment of locally advanced and resectable G/GEJ cancer are underway. The exploration and discovery of new biomarker combinations based on tumor characteristics and tumor microenvironment, especially tumor immune microenvironment, are helpful to screen superior patients and realize precise immunotherapy. Methods We selected 268 consecutive AGC patients who were treated with ICI therapy from December 2014 to May 2021. We measured their pretreatment the prognostic nutritional index (PNI) levels and performed univariate and multivariate Cox regression analyses of progression-free survival (PFS) or overall survival (OS) after ICI therapy. Results The low pretreatment PNI level of AGC patients was significantly correlated with shorter PFS (P<0.001) and OS (P<0.001) after ICI treatment. In univariate and multivariate analyses of the associations between neutrophil lymphocyte ratio (NLR), lymphocyte to monocyte ratio (LMR) or PNI, and OS or PFS, PNI (HR=1.483; 95% CI, 1.129-1.947; P=0.005) and NLR (HR=1.531; 95% CI, 1.164-2.014; P=0.002), but not LMR (HR=1.130; 95% CI, 0.829-1.538;P=0.440) are independent prognostic factors for PFS. Moreover, PNI (HR=1.385; 95% CI, 1.004-1.911; P=0.048) and LMR (HR=1.433; 95% CI, 1.039-1.977; P=0.028), but not NLR (HR=1.277; 95% CI, 0.896-1.820; P=0.176) are independent prognostic factors for OS. Conclusion The pretreatment PNI might help to identify AGC patients who will obtain a survival benefit from ICI therapy. The low pretreatment PNI is related to unsatisfactory survival outcomes.

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Section: Discussionmentioning

confidence: 99%

The Prognostic Value of Prognostic Nutritional Index in Patients With Advanced or Metastatic Gastric Cancer Treated With Immunotherapy

Pan¹,

Dai²

2023

Preprint

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“…Neutrophils were not only conversely associated with OS, PFS and DFS [37] , but also predicted a less favorable response to immunotherapy in various tumors [38] , and served as oncogenic factors that can even induce acquire immunosuppressive and tumor progression [39] . A higher dNLR is a potential hallmark of deficient cell mediated immunity and systemic inflammation, which may underlie the promotion of angiogenesis, DNA alteration and tumor proliferation [40] .…”

Section: Discussionmentioning

confidence: 99%

Distinct molecular phenotype and the potential prognostic value of immune prognostic index and tumor infiltrating lymphocytes in hepatoid adenocarcinoma of stomach

Kang

Shi

et al. 2022

Translational Oncology

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“…In recent years, especially neutrophils gained a lot of attention in this context. Although described as short-lived effector cells, they seem to acquire immunosuppressive and pro-tumorigenic functions and their role in cancer has been related to metastasis [ 13 , 14 ]. In this regard, neutrophils were shown to promote cancer cell entry into blood vessels [ 15 ] and comprehensive transcriptomic analysis of CTC–WBC cluster in BC patients indicated that CTCs associated with neutrophils promoted cell cycle progression, leading to more efficient metastasis formation [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

In Early Breast Cancer, the Ratios of Neutrophils, Platelets and Monocytes to Lymphocytes Significantly Correlate with the Presence of Subsets of Circulating Tumor Cells but Not with Disseminated Tumor Cells

Kasimir‐Bauer

Karaaslan

Hars

et al. 2022

Cancers

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Circulating tumor cells (CTCs) crosstalk with different blood cells before a few of them settle down as disseminated tumor cells (DTCs). We evaluated the correlation between CTC subtypes, DTCs and the neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and monocyte to lymphocyte ratio (MLR) for better prognostication of 171 early staged diagnosed breast cancer (BC) patients. —Clinical data and blood values before treatment were retrospectively recorded, representing the 75% percentile, resulting in 3.13 for NLR, 222.3 for PLR and 0.39 for MLR, respectively. DTCs were analyzed by immunocytochemistry using the pan-cytokeratin antibodyA45-B/B3. CTCs were determined applying the AdnaTests BreastCancerDetect and EMT (Epithelial Mesenchymal Transition) Detect. —Reduced lymphocyte (p = 0.007) and monocyte counts (p = 0.012), an elevated NLR (p = 0.003) and PLR (p = 0.001) significantly correlated with the presence of epithelial CTCs while a reduced MLR was related to EMT-CTCs (p = 0.045). PLR (p = 0.029) and MLR (p = 0.041) significantly related to lymph node involvement and monocyte counts significantly correlated with OS (p = 0.034). No correlations were found for NLR, PLR and MLR with DTCs, however, DTC-positive patients, harboring a lower PLR, had a significant shorter OS (p = 0.043). —Pro-inflammatory markers are closely related to different CTC subsets. This knowledge might improve risk prognostication of these patients.

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Neutrophils in cancer—unresolved questions

Cited by 9 publications

References 120 publications

The Prognostic Value of Prognostic Nutritional Index in Patients With Advanced or Metastatic Gastric Cancer Treated With Immunotherapy

The Prognostic Value of Prognostic Nutritional Index in Patients With Advanced or Metastatic Gastric Cancer Treated With Immunotherapy

Distinct molecular phenotype and the potential prognostic value of immune prognostic index and tumor infiltrating lymphocytes in hepatoid adenocarcinoma of stomach

In Early Breast Cancer, the Ratios of Neutrophils, Platelets and Monocytes to Lymphocytes Significantly Correlate with the Presence of Subsets of Circulating Tumor Cells but Not with Disseminated Tumor Cells

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