Neutrophils in asthma—A review

Ciepiela, Olga; Ostafin, Magdalena; Demkow, Urszula

doi:10.1016/j.resp.2014.12.004

Cited by 72 publications

(59 citation statements)

References 33 publications

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“…At the end of the experiment, no adult parasites or larval states were found in any treatment. The activation of eosinophils in inflammatory processes and immune response against helminths is regulated by interleukins IL-4, IL-8, IL-13 and TNF-α (Horrigan et al 2004, Ciepiela et al 2015. Additionally, some receptors are differentially expressed between eosinophils and neutrophils, such as the glucagon-like peptide 1 receptor (GLP-1R) (Mitchell et al 2017) and adenosine A3 receptor (A A3 R) (Ezeamuzie Table 1.…”

Section: Resultsmentioning

confidence: 99%

Health status and productivity of sheep fed coffee pulp during fattening

Bautista

Rodríguez-Magadán²,

Villegas-Sánchez

et al. 2018

Austral j. vet. sci.

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ABSTRACT. The objective of this study was to evaluate the productivity and health of fattening lambs fed different levels of coffee pulp in their diets. Thirty-five crossbred lambs with an average weight of 21.8 kg were fed isoproteic and isoenergetic diets with different percentages of coffee pulp (T0: control; T1: 7%; T2: 14%, T3: 21% and T4: 28%), the base diet was formulated with corn, soybean meal, alfalfa stubble, molasses, urea and mineral salt. The fattening period was 98 days. Productivity was measured by weight gain, feed intake and feed conversion. At the beginning and end of the study, blood samples were taken to determine the health status using a biochemical profile and blood count. Analysis of variance was performed using the initial weight as the covariate for the productive variables and the initial values of the analytes in the blood chemistry and hematological analysis tests. The coffee pulp did not affect productivity, although the amount of neutrophils decreased (P<0.05) as the coffee pulp in the diet increased. In all treatments, urea exceeded the reference values, whereas creatinine was below the reference values. We concluded that the inclusion of up to 28% coffee pulp in the diet did not affect the productive parameters, decreases the neutrophil count without affect health status of lambs during fattening.

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Section: Resultsmentioning

confidence: 99%

Health status and productivity of sheep fed coffee pulp during fattening

Bautista

Rodríguez-Magadán²,

Villegas-Sánchez

et al. 2018

Austral j. vet. sci.

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“…It is hypothesised that, in the context of asthma, neutrophils are pathogenic and are associated with more severe disease [46]. However, this is becoming increasingly less certain.…”

Section: The Role Of Neutrophils In Asthma and Relationships With Remmentioning

confidence: 99%

Novel concepts in airway inflammation and remodelling in asthma

2015

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The hallmark pathological features of asthma include airway eosinophilic inflammation and structural changes (remodelling) which are associated with an irreversible loss in lung function that tracks from childhood to adulthood. In parallel with changes in function, pathological abnormalities occur early, during the pre-school years, are established by school age and subsequently remain (even though symptoms may remit for periods during adulthood). Given the equal importance of inflammation and remodelling in asthma pathogenesis, there is a significant disparity in studies undertaken to investigate the contribution of each. The majority focus on the role of inflammation, and although novel therapeutics such as those targeted against T-helper cell type 2 (Th2) mediators have arisen, it is apparent that targeting inflammation alone has not allowed disease modification. Therefore, unless airway remodelling is addressed for future therapeutic strategies, it is unlikely that we will progress towards a cure for asthma. Having acknowledged these limitations, the focus of this review is to highlight the gaps in our current knowledge about the mechanisms underlying airway remodelling, the relationships between remodelling, inflammation and function, remodelling and clinical phenotypes, and the importance of utilising innovative and realistic pre-clinical models to uncover effective, disease-modifying therapeutic strategies. @ERSpublications We discuss mechanisms of airway inflammation and remodelling in asthma to uncover effective therapeutic strategies http://ow.ly/SsXiO

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“…Neutrophils is generally found in respiratory tract using bronchoalveolar lavage (BAL) test in asthmatic patients especially in those with severe asthma, but the correlation between degree of asthma control and increasing amount of neutrophils in peripheral blood test is still unknown. 7 This study purpose is getting to assess the correlation between total IgE and serum neutrophils toward the degrees of asthma control in adults atopic patients. The previous study has established the correlation between specific IgE-allergen and sputum neutrophils with degrees of asthma control, but none of the study has done to assess …”

Section: Introductionmentioning

confidence: 99%

The Relationship between Total Ige and Neutrophils Count with Degrees of Asthma Control in Adult Atopic Patients

Surachmanto¹,

Hatta²,

Islam³

et al. 2018

AJMBR

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Introduction: Asthma is a chronic reversible inflammation which is caused by bronchial hypereactivity due to exposure to allergen and hyperproduction of certain specific IgE. Neutrophil in respiratory tract and high level of IgE in the blood serum is known to play in complex mechanism in asthma development. The role of total IgE serum and neutrophil serum in asthma development is still not well known. Aim: This study aim is to assess the correlation between level of total IgE and neutrophil serum with degree of asthma control. Methods: This is a cross sectional study with 35 adult subjects with atophy asthma (age 22-61), all of participant reside in Manado and its surrounding area. Degree of asthma control is categorized as intermittent, mild persistent, moderate persistent and severe persistent based on criteria by GINA. Patient with malignancy, sepsis, lung tuberculosis, diabetes mellitus, pregnant, and late stage chronic kidney disease are excluded from this study. Result: In this study there is no significant correlation between total IgE serum level and degree of asthma control (p>0.05.) also there is no significant correlation between each total IgE level and each degree of asthma control. There is significant positive correlation between neutrophil count and degree of asthma control (r = 0.309; p<0.05). The higher neutrophil count is higher in mild persistent asthma in comparison with intermittent asthma is found to be significant (p<0.05). Conclusion:The neutrophil count in serum is related to degree of asthma control. Especially neutrophil count in mild persistent is higher than intermittent asthma. There is no correlation between total IgE level with degree of asthma control in adult subject with atopic asthma.

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Neutrophils in asthma—A review

Cited by 72 publications

References 33 publications

Health status and productivity of sheep fed coffee pulp during fattening

Health status and productivity of sheep fed coffee pulp during fattening

Novel concepts in airway inflammation and remodelling in asthma

The Relationship between Total Ige and Neutrophils Count with Degrees of Asthma Control in Adult Atopic Patients

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