Neutrophils from pulmonary tuberculosis patients show augmented levels of chemokines MIP-1α, IL-8 and MCP-1 which further increase upon in vitro infection with mycobacterial strains

Hilda, J. Nancy; Meenakshi, N.; Das, Sulochana D.

doi:10.1016/j.humimm.2014.06.020

Cited by 31 publications

(22 citation statements)

References 35 publications

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“…As mentioned, neutrophil-derived chemokines may also orchestrate more sophisticated responses involving adaptive immune cells. For example, neutrophils isolated from pulmonary tuberculosis patients were shown to display augmented levels of CXCL8, CCL2 and CCL3, which further increased upon infection with mycobacterial strains in vitro [44]. Consistently, it has been demonstrated that neutrophils exposed to Mycobacterium bovis Bacillus Calmette-Guerin (BCG) [45], or incubated with HP-NAP [37], produce not only CXCL8, but also CCL3 and CCL4, two chemokines recruiting monocytes, DCs and T cells to the site of infections.…”

Section: Human Neutrophilsmentioning

confidence: 73%

Neutrophil-derived chemokines on the road to immunity

Tecchio

Cassatella

2016

Seminars in Immunology

199

141

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During recent years, it has become clear that polymorphonuclear neutrophils are remarkably versatile cells, whose functions go far beyond phagocytosis and killing. In fact, besides being involved in primary defense against infections-mainly through phagocytosis, generation of toxic molecules, release of toxic enzymes and formation of extracellular traps-neutrophils have been shown to play a role in finely regulating the development and the evolution of inflammatory and immune responses. These latter neutrophil-mediated functions occur by a variety of mechanisms, including the production of newly manufactured cytokines. Herein, we provide a general overview of the chemotactic cytokines/chemokines that neutrophils can potentially produce, either under inflammatory/immune reactions or during their activation in more prolonged processes, such as in tumors. We highlight recent observations generated from studying human or rodent neutrophils in vitro and in vivo models. We also discuss the biological significance of neutrophil-derived chemokines in the context of infectious, neoplastic and immune-mediated diseases. The picture that is emerging is that, given their capacity to produce and release chemokines, neutrophils exert essential functions in recruiting, activating and modulating the activities of different leukocyte populations.

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Section: Human Neutrophilsmentioning

confidence: 73%

Neutrophil-derived chemokines on the road to immunity

Tecchio

Cassatella

2016

Seminars in Immunology

199

141

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“…In vitro, human neutrophils express both CCR1 and produce CCL3 upon infection with Mtb (373). Infection with Mtb induces the expression of the CCR1 ligands CCL3, CCL4 and CCL5 in the lung (374, 375), however, CCR1 deficiency in mice does not impact control or disease progression following Mtb infection (35).…”

Section: The Chemokinesmentioning

confidence: 99%

“…CXCL8 is present at high levels at positive tuberculin skin reaction sites and is associated with high levels of neutrophils at this site (436). Furthermore, neutrophils isolated from pulmonary TB patients have increased expression of CXCL8, which is further increased following ex vivo infection with H37Rv but not the clinical strains, S7 and S10, suggesting strain-specific regulation of CXCL8 production in neutrophils (373). Whether CXCL8 is associated with a protective or pathologic response remains controversial (437, 438).…”

Section: The Chemokinesmentioning

confidence: 99%

Cytokines and Chemokines inMycobacterium tuberculosisInfection

et al. 2016

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Chemokines and cytokines are critical for initiating and coordinating the organized and sequential recruitment and activation of cells into Mycobacterium tuberculosis -infected lungs. Correct mononuclear cellular recruitment and localization are essential to ensure control of bacterial growth without the development of diffuse and damaging granulocytic inflammation. An important block to our understanding of TB pathogenesis lies in dissecting the critical aspects of the cytokine/chemokine interplay in light of the conditional role these molecules play throughout infection and disease development. Much of the data highlighted in this review appears at first glance to be contradictory, but it is the balance between the cytokines and chemokines that is critical, and the “goldilocks” (not too much and not too little) phenomenon is paramount in any discussion of the role of these molecules in TB. Determination of how the key chemokines/cytokines and their receptors are balanced and how the loss of that balance can promote disease is vital to understanding TB pathogenesis and to identifying novel therapies for effective eradication of this disease.

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“…Indeed, CCL-3, CXCL-8 and CCL-2 expression was upregulated in neutrophils isolated from patients with pulmonary TB in comparison to healthy controls, and following in vitro Mtb infection [42]. In addition, the CCL-2 2518G allele, which results in exacerbated CCL-2 secretion [43], and combinations of single-nucleotide polymorphisms in the CCL-5 promoter [24] have been associated with TB in human populations.…”

Section: Chemokines Mediate Inflammation During Tb (The Bad)mentioning

confidence: 99%

Chemokines in tuberculosis: The good, the bad and the ugly

Monin

Khader

2014

Seminars in Immunology

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Mycobacterium tuberculosis (Mtb) infects about one third of the world’s population, with a majority of infected individuals exhibiting latent asymptomatic infection, while 5–10% of infected individuals progress to active pulmonary disease. Research in the past two decades has elucidated critical host immune mechanisms that mediate Mtb control. Among these, chemokines have been associated with numerous key processes that lead to Mtb containment, from recruitment of myeloid cells into the lung to activation of adaptive immunity, formation of protective granulomas and vaccine recall responses. However, imbalances in several key chemokine mediators can alter the delicate balance of cytokines and cellular responses that promote mycobacterial containment, instead precipitating terminal tissue destruction and spread of Mtb infection. In this review, we will describe recent insights in the involvement of chemokines in host responses to Mtb infection and Mtb containment (the good), chemokines contributing to inflammation during TB (the bad), and the role of chemokines in driving cavitation and lung pathology (the ugly).

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Neutrophils from pulmonary tuberculosis patients show augmented levels of chemokines MIP-1α, IL-8 and MCP-1 which further increase upon in vitro infection with mycobacterial strains

Cited by 31 publications

References 35 publications

Neutrophil-derived chemokines on the road to immunity

Neutrophil-derived chemokines on the road to immunity

Cytokines and Chemokines inMycobacterium tuberculosisInfection

Chemokines in tuberculosis: The good, the bad and the ugly

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