2016
DOI: 10.1371/journal.pone.0160249
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Neutrophils Directly Recognize Group B Streptococci and Contribute to Interleukin-1β Production during Infection

Abstract: Previous studies have shown that the pro-inflammatory cytokine IL-1β has a crucial role in host defenses against group B streptococcus (GBS), a frequent human pathogen, by recruiting neutrophils to infection sites. We examined here the cell types and mechanisms involved in IL-1β production during infection. Using a GBS-induced peritonitis model in mice, we first found that a large proportion of exudate cells contain intracellular IL-1β by immunofluorescence. Of the IL-1β positive cells, 82 and 7% were neutroph… Show more

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Cited by 35 publications
(43 citation statements)
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“…It is likely that in the absence of neutrophil cell death, the expression of neutrophil recruiting cytokines and chemokines by chorioamniotic membranes and the release of IL-8 from activated neutrophils themselves may support the recruitment of additional neutrophils that assist in GBS phagocytosis. Consistent with this hypothesis, Mohammadi et al recently reported that murine bone marrow derived neutrophils released TNF and IL-1β when exposed to GBS for 24 hours (64). Taken together, these observations suggest that when neutrophils escape cytotoxic killing by the GBS hemolytic pigment, cytokine responses may promote additional neutrophil recruitment.…”
Section: Discussionmentioning
confidence: 66%
“…It is likely that in the absence of neutrophil cell death, the expression of neutrophil recruiting cytokines and chemokines by chorioamniotic membranes and the release of IL-8 from activated neutrophils themselves may support the recruitment of additional neutrophils that assist in GBS phagocytosis. Consistent with this hypothesis, Mohammadi et al recently reported that murine bone marrow derived neutrophils released TNF and IL-1β when exposed to GBS for 24 hours (64). Taken together, these observations suggest that when neutrophils escape cytotoxic killing by the GBS hemolytic pigment, cytokine responses may promote additional neutrophil recruitment.…”
Section: Discussionmentioning
confidence: 66%
“…Neutrophils from patients with active systemic‐onset JIA showed increased gene expression of IL‐1β, inflammasome components, and genes involved in the NF‐κB pathway, indicating that there was an increased production of IL‐1β. Recent studies highlighted the importance of neutrophils as a source of IL‐1β in several models of inflammatory and infectious diseases, and demonstrated the capability of neutrophils to secrete IL‐1β in either an inflammasome‐dependent or inflammasome‐independent manner . Those investigators concluded that, despite the relatively low production of IL‐1β by neutrophils compared to monocytes, neutrophils can still be a major source of IL‐1β, due to their abundance in the peripheral blood and at the site of inflammation.…”
Section: Discussionmentioning
confidence: 99%
“…Activation of caspase‐1 in neutrophils has been described after stimulation with Streptococcus pneumoniae and group B streptococci , and found to be dependent on pore‐forming pneumolysin and GBS haemolysin, respectively. Serotypes of S. pneumoniae expressing non‐haemolytic pneumolysins can evade activation of the inflammasome and induce low levels of IL‐1β compared to serotypes expressing haemolytic pneumolysin .…”
Section: Discussionmentioning
confidence: 99%
“…On the other hand, neutrophils constitute 50–70% of white blood cells, and human peripheral neutrophils have been found to be a considerable source for IL‐1β ex vivo , suggesting that they have the potential to influence plasma levels of IL‐1β. We chose to study IL‐1β release from neutrophils, as they are recruited to the prosthetic joint in the process of sterile inflammation early after surgical trauma and have been found to be the most abundant cell type producing IL‐1β during early infection, as demonstrated with group B streptococci .…”
Section: Discussionmentioning
confidence: 99%