Neutrophils and Neutrophil Extracellular Traps Cause Vascular Occlusion and Delayed Cerebral Ischemia After Subarachnoid Hemorrhage in Mice
Hussein A. Zeineddine,
Sung-Ha Hong,
Pedram Peesh
et al.
Abstract:Background:
After subarachnoid hemorrhage (SAH), neutrophils are deleterious and contribute to poor outcomes. Neutrophils can produce neutrophil extracellular traps (NETs) after ischemic stroke. Our hypothesis was that, after SAH, neutrophils contribute to delayed cerebral ischemia (DCI) and worse outcomes via cerebrovascular occlusion by NETs.
Methods:
SAH was induced via endovascular perforation, and SAH mice were given either a neutrophil-depleting a… Show more
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