Neutrophils and Mononuclear Cells Express Vascular Endothelial Growth Factor in Acute Kawasaki Disease: Its Possible Role in Progression of Coronary Artery Lesions

Hamamichi, Yuji; Ichida, Fukiko; Yu, Xiao‐Juan; Hirono, Keiichi; Uese, Keiichiro; Hashimoto, Ikuo; Tsubata, Shinichi; Yoshida, Taketoshi; Futatani, Takeshi; Kanegane, Hirokazu; Miyawaki, Toshio

doi:10.1203/00006450-200101000-00017

Cited by 73 publications

(58 citation statements)

References 40 publications

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“…During the early acute phase of KD, production of VEGF-A in peripheral blood mononuclear cells markedly increases, especially in patients with CALs. 19 In autopsied patients with a history of KD, VEGF-A expression has been observed within smooth muscle cells; VEGF-A is particularly highly expressed in the newly formed microvessels within the intima of affected human hearts in the later chronic inflammation stages of the disease. 5 In our study, similar to these findings in human KD, VEGF-A production by PBLs in LCWEtreated mice was significantly augmented on days 3 and 7 after injection.…”

Section: Discussionmentioning

confidence: 99%

Vascular Endothelial Growth Factor-A in <i>Lactobacillus Casei </i>Cell Wall Extract-Induced Coronary Arteritis of a Murine Model

Lin

Sheen

Tain

et al. 2014

Circ J

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Section: Discussionmentioning

confidence: 99%

Vascular Endothelial Growth Factor-A in <i>Lactobacillus Casei </i>Cell Wall Extract-Induced Coronary Arteritis of a Murine Model

Lin

Sheen

Tain

et al. 2014

Circ J

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“…VEGF is an angiogenic growth factor that has been implicated in both physiological and pathological angiogenesis [19]. Several investigators have reported the increased levels of angiogenic factors such as VEGF and hepatocyte growth factor (HGF) in KD, thus suggesting VEGF to be a marker of the hyperpermeability of local blood vessels [17] or a predictive indicator for the occurrence of CAL in acute KD [18,20]. As a result, the increased production of VEGF may promote coronary vascular injury by inducing the migration of ECs and enhancing vascular permeability.…”

Section: Discussionmentioning

confidence: 99%

Imbalance in the production between vascular endothelial growth factor and endostatin in Kawasaki disease

Takeshita

Kawamura

Takabayashi

et al. 2005

Clinical and Experimental Immunology

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SummaryTo investigate whether an imbalance exists in the production between angiogenic and antiangiogenic growth factors in patients with Kawasaki disease (KD), we measured the serum levels of vascular endothelial growth factor (VEGF) and endostatin (ES) in 35 patients with KD, 15 patients with acute febrile diseases (disease controls) and 15 healthy children. KD patients had significantly higher VEGF levels and lower ES levels ( P < < < < 0·01) in the acute and subacute phases than the disease control and healthy children. KD patients with coronary artery lesions (CAL, n = = = = 10) had significantly higher VEGF levels and lower ES levels ( P < < < < 0·05) in the subacute and convalescent phases than those without CAL ( n = = = = 25). The ratios of VEGF/ES in sera of KD patients with CAL were significantly higher ( P < < < < 0·05) in the acute and convalescent phases compared to those without CAL. Furthermore, the occurrence of CAL significantly correlated with the VEGF/ES ratio above 10 ¥ ¥ ¥ ¥ 10----3 in the subacute phase of KD (Odds ratio 17·25, P = = = = 0·005). The findings in the present study indicate that an imbalance exists in the production between VEGF and ES in patients with KD while also suggesting that KD patients with a high VEGF/ES ratio have a significantly greater risk of CAL involvement.

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“…The up-regulation of the adhesion molecule expression of neutrophils in acute KD: Hamamichi et al reported that circulating neutrophils abundantly express vascular endothelial growth factor (VEGF) in the acute phase of KD, suggesting that neutrophil-derived VEGF may contribute to the vascular injury and remodeling observed in KD vasculitis [21]. The CD11b expression of circulating neutrophils was increased in the acute phase of KD and was positively correlated with the serum levels of IL-6, IL-10, and granulocyte colony-stimulating factor (G-CSF) [22].…”

Section: The Increased Number Of Neutrophils and The Morphological Chmentioning

confidence: 99%

The Role of Neutrophil Activation in the Pathogenesis of Kawasaki Disease

Takeshita¹,

Kawamura²,

Kanai³

et al. 2018

Pediatric Infect Dis

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In the acute phase of Kawasaki disease (KD), there is an increase in the number of circulating neutrophils, including toxic neutrophils, which are caused by a morphological change. The functions of the neutrophils are also activated, leading to the excessive production of reactive oxygen species and elastase, which may induce endothelial cell (EC) injury. Histological findings demonstrate that numerous neutrophils infiltrate into coronary artery lesions (CALs) during the early phase of KD. Thus, it is suggested that neutrophil-mediated EC injury may be involved in the formation of CALs in KD patients. In this review, we focus on the role of neutrophil activation in the pathogenesis of KD vasculitis and discuss the methods of treatment for neutrophil-mediated EC injury.

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Neutrophils and Mononuclear Cells Express Vascular Endothelial Growth Factor in Acute Kawasaki Disease: Its Possible Role in Progression of Coronary Artery Lesions

Cited by 73 publications

References 40 publications

Vascular Endothelial Growth Factor-A in <i>Lactobacillus Casei </i>Cell Wall Extract-Induced Coronary Arteritis of a Murine Model

Vascular Endothelial Growth Factor-A in <i>Lactobacillus Casei </i>Cell Wall Extract-Induced Coronary Arteritis of a Murine Model

Imbalance in the production between vascular endothelial growth factor and endostatin in Kawasaki disease

The Role of Neutrophil Activation in the Pathogenesis of Kawasaki Disease

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