Neutrophilic Myeloperoxidase–Macrophage Interactions Perpetuate Chronic Inflammation Associated with Experimental Arthritis

Lefkowitz, Doris L.; Gelderman, Monique P.; Fuhrmann, Steven R.; Graham, Suzanne; Starnes, Joel; Lefkowitz, Stanley S.; Bollen, Alex; Moguilevsky, Nicole

doi:10.1006/clim.1999.4696

Cited by 84 publications

(57 citation statements)

References 35 publications

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“…Similarly, the reports of perceived improvement in the experience of arthritic pain lend support to the findings of saccharide involvement in arthritic conditions (A. Alavi & Axford, 2008;Gelderman, et al, 1998;Kossi, Peltonen, Ekfors, Niinikoski, & Laato, 1999;Lefkowitz, et al, 1999). In addition, the perceived changes in psychological well-being are consistent with the role of polysaccharides within the brain that may influence the regulation of mood, namely cell interactions and neurotransmitter response (Chicoine & Bahr, 2007;Hirano, et al, 2003;Kleene & Schachner, 2004;Krishnan & Nestler, 2010;Martin, 2002;Matthies, et al, 1996).…”

Section: Discussionsupporting

confidence: 65%

Perceived Changes in Well-Being Following Polysaccharide Intake in Middle-Aged Adults

Best

Kemps

Bryan

2011

Applied Research Quality Life

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Objectives: There is increased scientific interest in the effects of nutrition on cognition and well-being. Plant sourced polysaccharides play multiple roles in the biological processes required for health and well-being. This study explored the subjective experiential reports of well-being following intake of a plant derived polysaccharide supplement.Design: The study used a 12 week double-blind, placebo controlled polysaccharide supplementation design.Method: 109 middle-aged adults (45-60 years) took a standardised teaspoon of a combination of plant polysaccharides or a placebo twice daily for 12 weeks (3.6 g per day), and completed three, open-ended interviews at weeks 4, 8 and 12.Results: Participants who took the polysaccharide supplement reported significantly more perceived beneficial changes in both physical and psychological well-being, specifically at week 12, compared to those who received the placebo.Conclusion: This study provides a starting point for understanding the perceived beneficial impact of polysaccharide interventions on aspects of well-being. Importantly, as a healthrelated application of polysaccharide science, this research supports the relationship that is emerging between the properties and function of polysaccharides. It is essential that future research assesses the effects of polysaccharide intake on a range of physical and psychological well-being outcomes to further the understanding of structure-function relationships with the aim of enhancing the functional health and well-being of individuals.

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Section: Discussionsupporting

confidence: 65%

Perceived Changes in Well-Being Following Polysaccharide Intake in Middle-Aged Adults

Best

Kemps

Bryan

2011

Applied Research Quality Life

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“…38 Increased MPO levels in the synovial tissue and paws of arthritic animals show the high neutrophil infiltration (accumulation) in the joints, because the levels of MPO are closely correlated to the number of neutrophils present in the tissue. 39 Large numbers of neutrophils were observed in synovial fluid and joint tissues during the early stage of rheumatoid arthritis and were implicated as major mediators of tissue destruction as seen by the release of nonenzyme mediators such as oxygen metabolites and enzyme mediators such as elastase and collagenase. 40 Polymorphonuclear leukocytes (PMN) recruited in the synovial cavity of rheumatoid arthritic patients damage the joints by releasing proteases and oxygen/nitrogen metabolites.…”

Section: Discussionmentioning

confidence: 99%

Effect ofSemecarpus anacardium Linn. nut milk extract on rat neutrophil functions in adjuvant arthritis

Ramprasath

Shanthi

Sachdanandam

2006

Cell Biochem. Funct.

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Neutrophils play an important role in the pathogenesis of rheumatoid arthritis (RA) and various inflammatory conditions, by accumulation and liberation of active proteolytic enzymes. The effect of milk extract of Semecarpus anacardium Linn. nuts (SA) at a dosage of 150 mg kg(-1) body weight day(-1) for 14 days on adjuvant arthritis was studied to gain some insight into this intriguing disease in relation to neutrophil functions. The decreased phagocytic function of neutrophils (phagocytic index and avidity index) found in adjuvant arthritis was significantly increased by the administration of the drug SA. Increased levels of reactive oxygen species (superoxide radical, hydroxyl radical, H2O2 and myeloperoxidase), lysosomal enzymes (acid phosphatase and cathepsin D) and increased accumulation of neutrophils in the joints observed in adjuvant arthritic animals were reverted back to near normal levels by treatment with SA. The results of this study indicate that SA can be considered to be a good therapeutic agent for inflammation and arthritis.

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“…Both MPO and cytokines participate in the recruitment of cells into the area of inflammation. Lefkowitz et al (1999) reported that MPO may be an important mediator in the inflammatory response. Moreover, in the scale of systemic OS parameters, phagocytosis, oxidative burst and metabolic activity of rat granulocytes isolated from peripheral blood were monitored.…”

Section: Adjuvant Arthritis: An Animal Model For Preclinical Evaluatimentioning

confidence: 99%

Modern Pharmacological Approaches to Therapies: Substances Tested in Animal Models of Rheumatoid Arthritis

Bauerová¹,

Poništ²,

Nosáľ³

et al. 2012

Rheumatoid Arthritis - Treatment

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Neutrophilic Myeloperoxidase–Macrophage Interactions Perpetuate Chronic Inflammation Associated with Experimental Arthritis

Cited by 84 publications

References 35 publications

Perceived Changes in Well-Being Following Polysaccharide Intake in Middle-Aged Adults

Perceived Changes in Well-Being Following Polysaccharide Intake in Middle-Aged Adults

Effect ofSemecarpus anacardium Linn. nut milk extract on rat neutrophil functions in adjuvant arthritis

Modern Pharmacological Approaches to Therapies: Substances Tested in Animal Models of Rheumatoid Arthritis

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