Neutrophilic Generalized Fixed Drug Eruption Induced by Etoricoxib

Vera, A; Freih, Alwalid; Múgica, M. Álvarez; Vega, F A; Belver, María Teresa; Blanco, C. Ciudad

doi:10.18176/jiaci.0687

Cited by 6 publications

(2 citation statements)

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“…Neutrophilic FDE has previously been reported to be associated with naproxen, as was seen in Case 1 above 8,9 . Other reported causative agents include amoxicillin–clavulanic acid, sulfamethoxazole–trimethoprim, etoricoxib, and gabapentin 5,6,8,11,12 . Interestingly, the entity has also been reported in a case of seafood ingestion, aptly termed “neutrophilic fixed food eruption.” 13 …”

Section: Discussionmentioning

confidence: 89%

“…causative agents include amoxicillin-clavulanic acid, sulfamethoxazoletrimethoprim, etoricoxib, and gabapentin. 5,6,8,11,12 Interestingly, the entity has also been reported in a case of seafood ingestion, aptly termed "neutrophilic fixed food eruption." 13 As previously mentioned, the entity may be incorrectly identified as a neutrophilic dermatosis given the histopathologic findings, especially since the interface reaction may be subtle, as in our cases.…”

Section: Discussionmentioning

confidence: 97%

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Neutrophilic fixed drug eruption, a histopathologic variant or an expected finding?—A report of two cases and review of the literature

et al. 2023

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Fixed drug eruption (FDE) is an adverse drug reaction characterized by recurrent circumscribed lesions at the same location upon re-exposure to the culprit medication, resulting in distinct postinflammatory hyperpigmentation. Histopathologically, FDE demonstrates a predominantly lymphocytic interface or lichenoid infiltrate with basal cell vacuolar changes and keratinocyte dyskeratosis/apoptosis. The term "neutrophilic fixed drug eruption" has been used to describe cases in which the inflammatory infiltrate is predominantly neutrophilic. The infiltrate can extend deeper in the dermis, potentially mimicking a neutrophilic dermatosis such as Sweet syndrome.We present two cases and review the literature to discuss the possibility that a neutrophilic inflammatory infiltrate may be an expected finding in FDE, rather than a histopathologic variant.

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Section: Discussionmentioning

confidence: 89%