Neutrophilic figurate erythema of infancy associated with juvenile myelomonocytic leukemia

Arcuate erythematous plaques on the trunk

“…[ 3 ] Rarely, the condition may be associated with underlying malignancies (Hodgkin lymphoma, juvenile myelomonocytic leukemia), and a meticulous systemic work-up needs to be done. [ 4 5 ] Various therapeutic modalities have been tried, including topical steroids, systemic steroids, anti-histamines, dapsone, colchicine, and chemotherapy. The index case was prescribed dapsone, to which the lesions responded well.…”

Misdiagnosis of neutrophilic erythema of infancy as leukocytoclastic vasculitis: A potential diagnostic pitfall in an infantile inflammatory dermatosis

“…1 Only six cases of NFEI have been reported in the literature (Table 1). 1,2,[4][5][6][7] NFEI is characterized clinically by annular or figurate erythematous lesions and histopathologically by neutrophilic infiltration of the dermis with leukocytoclasia and without primary vascular damage. 1 As shown in our case, the diagnosis may be challenging, and there is a significant potential for misdiagnosis as leukocytoclastic vasculitis without clear communication and correlation with pediatric dermatology colleagues.…”

“…2 Based on the review of the literature, the majority of cases of NFEI are selflimiting over the course of a few months. 1,2,[4][5][6][7] Importantly, there is a case of a 2-year-old girl developing juvenile myelomonocytic leukemia shortly after being diagnosed with NFEI. 5 This has led some to consider NFEI to be a neutrophilic dermatosis, but additional studies are needed to determine whether a true association exists.…”

Leukemia cutis in a child with juvenile myelomonocytic leukemia presenting with Sweet syndrome–like lesions and a history of multiple juvenile xanthogranulomas

“…Only rare reports exist of Sweet syndrome occurring in children with leukemia, most commonly acute myelogenous leukemia, and are even rarer in JMML. 2 , 3 , 4 Leukemia cutis in children is extremely uncommon and is most often associated with acute myeloid leukemia followed by acute lymphoblastic leukemia. The median age at presentation is approximately 2 years, and lesions present commonly as erythematous-to-violaceous nodules or papules occurring on the head and lower limbs.…”