Neutrophilic eccrine hidradenitis in two neutropenic patients

Allegue, F.; Soria, C.; Rocamora, A.; Muñoz, Ernesto; Freire-Murgueytio, Patricio; Arrazola, J. M.; Ledo, A.

doi:10.1016/0190-9622(90)70342-f

Cited by 33 publications

(12 citation statements)

References 11 publications

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“…A skin biopsy was performed in 10 of 13 neutropenic patients and the three nonleukopenic patients. The latter three pa¬ tients exhibited clinical and histopathologic features of SS.…”

Section: Resultsmentioning

confidence: 99%

Neutrophilic Dermatoses During Granulocytopenia

Aractingi

Mallet²,

Pinquier³

et al. 1995

Arch Dermatol

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“…A skin biopsy was performed in 10 of 13 neutropenic patients and the three nonleukopenic patients. The latter three pa¬ tients exhibited clinical and histopathologic features of SS.…”

Section: Resultsmentioning

confidence: 99%

Neutrophilic Dermatoses During Granulocytopenia

Aractingi

Mallet²,

Pinquier³

et al. 1995

Arch Dermatol

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“…NEH has also been observed in human immunodeficiency virus (HIV)‐infected patients treated with antiretroviral drugs 3 . Necrosis of eccrine coils and glands has been reported in neutropenic patients with a striking lack of neutrophilic infiltration, suggesting that the neutrophilic infiltrate could be secondary to sweat gland abnormalities 4 . Another theory postulates that NEH, as with Sweet's syndrome, is a part of the spectrum of neutrophilic dermatoses.…”

Section: Discussionmentioning

confidence: 99%

Neutrophilic eccrine hidradenitis in non‐small cell lung cancer

Lee

Shin

et al. 2007

Int J Dermatology

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A 75-year-old man was treated for non-small cell lung cancer (NSCLC) (stage IIIb) with three-cycle chemotherapy (cisplatin and paclitaxel) for 3 weeks. No skin lesions were observed during the first and second chemotherapy cycles. After the third chemotherapy cycle, he developed slightly pruritic skin eruptions on the anterior chest. He was treated for 1 month with topical steroid without improvement, and was referred to our dermatologic department.Skin examination revealed slightly elevated, dusky, erythematous, edematous patches on the anterior chest in a bilateral distribution (Fig. 1).Histologic examination of a biopsy specimen taken from the cutaneous lesions showed a neutrophilic infiltrate surrounding the secretory eccrine glands. The epithelial cells of the eccrine ducts and coils were not affected. There was a mild superficial perivascular infiltrate of mainly lymphocytes. These changes were consistent with a diagnosis of neutrophilic eccrine hidradenitis (Fig. 2).He was treated with dapsone, 50 mg /day, and methylprednisolone, 8 mg /day, for 2 weeks, and his skin lesions improved. Two months later the erythematous eruptions recurred on the chest, back, and extremities without the use of any chemotherapeutic agent, and were treated effectively with the same drugs.

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“…The NEH literature does not report any neutrophilic infiltrates away from the eccrine sweat glands. In the setting of neutropenia the infiltrate may be sparse [5]. Squamous metaplasia is occasionally seen.…”

Section: Case Presentationmentioning

confidence: 99%

Two neutrophilic dermatoses captured simultaneously on histology

Wlodek

Bhatt

Kennedy

2016

Dermatol Pract Concept

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A number of neutrophilic dermatoses are associated with malignancies and their treatment. These rarely occur together in the same patient.A Caucasian 72-year-old male was treated for acute myeloid leukemia (AML) with chemotherapy including daunorubicin and cytarabine. Within 48 hours of commencing treatment, he developed pyrexia and, two days later, disseminated non-tender pink plaques on the limbs and trunk. A skin biopsy showed a dermal interstitial infiltrate of lymphocytes, histiocytoid cells and predominantly neutrophils. This extended into the subcutis, where a neutrophilic lobular panniculitis was seen. These findings are consistent with Sweet’s syndrome. In addition, a neutrophilic and lymphocytic infiltrate was also present around eccrine coils and lower ducts. The eccrine epithelium showed squamous metaplasia with dyskeratosis and sloughing into the lumen. These latter findings are consistent with neutrophilic eccrine hidradenitis (NEH).These two histologically distinct entities form part of the neutrophilic dermatoses that have been described in oncology patients with reports of concurrent or sequential occurrence of various neutrophilic dermatoses in the same patient. Ours, however, is only the second reported case of simultaneously captured Sweet’s and NEH in the setting of AML. The most likely explanation is that of an epiphenomenon, whereby the neutrophilic infiltrate extended around the sweat glands in the context of the neutrophilic dermatosis.

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Neutrophilic eccrine hidradenitis in two neutropenic patients

Cited by 33 publications

References 11 publications

Neutrophilic Dermatoses During Granulocytopenia

Neutrophilic Dermatoses During Granulocytopenia

Neutrophilic eccrine hidradenitis in non‐small cell lung cancer

Two neutrophilic dermatoses captured simultaneously on histology

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