Neutrophilic dermatosis of the dorsal hands (acral Sweet syndrome) with predominantly lymphocytic dermal infiltrate

Peteln, Irena; Dolenc‐Voljč, Mateja; Jurčić, Vesna

doi:10.1111/cup.13589

Cited by 3 publications

(7 citation statements)

References 10 publications

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“…In a recent case report, Peteln et al described a case of NDH with perivascular and interstitial lymphocytic infiltration where biopsy was taken from a 1- to 2-day-old pustule. [ 7 ] Similar histopathological findings were also corroborated by Kazlouskaya et al [ 8 ] and Jordaan[ 9 ] in a few cases of SS. Jordaan postulated that the lymphocytes appeared initially, generated lymphokines that attracted the neutrophils, resulting in a more robust neutrophilic component in the more developed elevated lesions.…”

Section: Discussionsupporting

confidence: 78%

“…NDH has been reported to be associated with solid organ malignancies (lung, larynx, kidney, and colon), hematological disorders (myelodysplastic syndrome, monoclonal gammopathy, multiple myeloma, acute myeloid leukemia, and polycythemia), autoimmune diseases, inflammatory bowel disease (ulcerative colitis, Crohn's disease), infections (mostly respiratory), and drugs. [ 6 7 ] Our patient was thoroughly evaluated but no such underlying association was found.…”

Section: Discussionmentioning

confidence: 98%

“…A comparison between the clinico-histopathological features of classic Sweet syndrome, NDH, and the present case has been depicted in Table 1 . [ 5 6 7 ]…”

Section: Discussionmentioning

confidence: 99%

“…In clinico-histopathological evaluation of hand lesions, consideration of neutrophilic eccrine hidradenitis (neutrophilic infiltrates around eccrine glands with vacuolar alteration and necrosis), chilblain lupus (positive ANA, vacuolar interface dermatitis with dermal mucin, positive direct immunofluorescence test), perniosis (lesions precipitated with cold exposure), arthropod bite reaction (self-limited, visible bite mark, dermal eosinophils), erysipelas (systemic symptoms, vascular ectasia, sparse dermal infiltrate, response to antibiotics), and a drug reaction (anamnesis) ought to be made and ruled out. [ 7 ]…”

Section: Discussionmentioning

confidence: 99%

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Neutrophilic Dermatosis of the Hands with Palmar Involvement and Predominant Lymphomononuclear Cell Infiltration

Panigrahi

Biswas

Sil

et al. 2021

Indian Journal of Dermatology

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Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 98%

“…A comparison between the clinico-histopathological features of classic Sweet syndrome, NDH, and the present case has been depicted in Table 1 . [ 5 6 7 ]…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Neutrophilic Dermatosis of the Hands with Palmar Involvement and Predominant Lymphomononuclear Cell Infiltration

Panigrahi

Biswas

Sil

et al. 2021

Indian Journal of Dermatology

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“…The diagnostic criteria proposed by von den Driesch require the fulfillment of both major criteria and two of the four minor criteria listed in Table 1 [29]. Of note, we point out that the von den Driesch criteria require neutrophilic infiltrate to diagnose SS; however, several reports have diagnosed SS despite the lack of a predominant neutrophilic infiltrate [30][31][32]. We recommend against the use of SS as an umbrella term to describe entities that present histologically with eosinophilic or lymphocytic infiltrate, despite presenting clinically as SS.…”

Section: Diagnostic Criteriamentioning

confidence: 78%

New Practical Aspects of Sweet Syndrome

et al. 2022

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Sweet syndrome (SS), or acute febrile neutrophilic dermatosis, is an inflammatory, non-infectious skin reaction characterized clinically by tender, erythematous papules/plaques/pustules/nodules commonly appearing on the upper limbs, trunk, and head and neck; histologically, SS is characterized by dense neutrophilic infiltrate in the dermis. SS is accompanied by fever; an elevation of inflammatory markers (e.g., erythrocyte sedimentation rate, C reactive protein) in serum may also be observed. Although most cases of SS are idiopathic, SS also occurs in the setting of malignancy or following administration of an associated drug. SS has also been reported in association with pregnancy and a burgeoning list of infectious (most commonly upper respiratory tract infections) and inflammatory diseases; likewise, the litany of possible iatrogenic triggers has also grown. Over the past several years, a wider spectrum of SS presentation has been realized, with several reports highlighting novel clinical and histological variants. Corticosteroids continue to be efficacious first-line therapy for the majority of patients with SS, although novel steroid-sparing agents have been recently added to the therapeutic armamentarium against refractory SS. New mechanisms of SS induction have also been recognized, although the precise etiology of SS still remains elusive. Here, we catalogue the various clinical and histological presentations of SS, summarize recently reported disease associations and iatrogenic triggers, and review treatment options. We also attempt to frame the findings of this review in the context of established and emerging paradigms of SS pathogenesis.

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Giant Cellulitis-like Sweet Syndrome Following Varicose Vein Surgery: A Rare Variant of Sweet Syndrome Mimicking Cellulitis

et al. 2023

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Giant cellulitis-like Sweet syndrome (GCS) is the most recently defined variant of Sweet syndrome (SS) which could clinically mimic wide-spreading cellulitis. Although there has been only paucity of reports in the literature, it mostly appears at lower half of the body and histologically shows dense infiltration of neutrophils with occasional histiocytoid mononuclear cells. Although its exact etiology has not been clarified, abnormal conditions (e.g., infection, malignancy and drugs) could be related triggering factors and trauma itself can be one of the causative elements as a ‘pathergy phenomenon’. GCS could be confusing manifestation especially when appeared in postoperative condition. A 69-year-old female presented with an erythematous edematous papules and plaques on the right thigh after varicose vein surgery. Skin biopsy revealed diffuse neutrophilic infiltrates that was consistent with SS. To our knowledge, there has been no report of GCS as a postoperative complication after varicose vein surgery. Physicians should be aware of this uncommon reactive neutrophilic dermatoses mimicking infectious cutaneous disease.

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Neutrophilic dermatosis of the dorsal hands (acral Sweet syndrome) with predominantly lymphocytic dermal infiltrate

Cited by 3 publications

References 10 publications

Neutrophilic Dermatosis of the Hands with Palmar Involvement and Predominant Lymphomononuclear Cell Infiltration

Neutrophilic Dermatosis of the Hands with Palmar Involvement and Predominant Lymphomononuclear Cell Infiltration

New Practical Aspects of Sweet Syndrome

Giant Cellulitis-like Sweet Syndrome Following Varicose Vein Surgery: A Rare Variant of Sweet Syndrome Mimicking Cellulitis

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