Neutrophilic dermatoses: Kids are not just little people

Successful treatment with oral methylprednisolone and cyclosporine for refractory pyoderma gangrenosum in children: Report of a case and review of the literature

“…It often requires combination therapies, especially in the pediatric population. Till now, the treatment has been almost based on case reports, so we summarized the therapies of PG in children here . In the literature review, corticosteroids with or without steroid‐sparing therapy are applied in 60% of all reported cases .…”

“…In the literature review, corticosteroids with or without steroid‐sparing therapy are applied in 60% of all reported cases . The two most commonly used steroid‐sparing agents in pediatric PG are dapsone (34.9%) and cyclosporine (30.4%) . PG responds to different treatments also depending on the setting and underlying associated diseases …”

Widespread skin erosions in a newborn

“…Development of the typical reticulated, supple scarring pattern upon healing later supports the diagnosis of CEVD. In some cases, recurrent vesicles or erosions up to age 9 have been reported, adding to the diagnostic challenge of excluding other vesiculobullous diseases such as EB …”

Cutaneous ulceration in an infant

“…Clinical appearance is similar in adults and children, although in contrast to adults, PG lesions tend to be disseminated and multiple in the pediatric population. Localized lesions are most likely to occur on the lower extremities, similar to adults …”

“…Other less commonly used systemic steroid‐sparing agents include mycophenolate mofetil, methotrexate, colchicine, azathioprine, sulfasalazine, 6‐mercaptopurine, and tacrolimus. If an underlying inflammatory bowel disease is identified, TNF‐α inhibitors, such as infliximab (5 mg/kg per dose) or adalimumab (40 mg every other week) were of choice for controlling both conditions . We shouldn't forget wound care as an important part in the optimal environment for wound healing …”