Neutrophilic dermatoses

Nelson, Caroline A.; Stephen, Sasha; Ashchyan, Hovik J.; James, William D.; Micheletti, Robert G.; Rosenbach, Misha

doi:10.1016/j.jaad.2017.11.064

Cited by 136 publications

(129 citation statements)

References 220 publications

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“…Because drug-induced Sweet syndrome is a diagnosis of exclusion, all patients should be screened for malignancy according to age. 4 Thrombocytosis, as found in our patient, is present in up to 50% of patients with drug-induced Sweet syndrome and is considered infrequent in classic Sweet syndrome. Also, oral mucosal involvement is present in up to 7% of patients with drug-induced Sweet syndrome, but only in 2% of patients with the classic syndrome.…”

Section: Discussionsupporting

confidence: 68%

“… 2 , 3 The latter has been reported to account for 1% to 26% of cases. 4 Several medications are associated with drug-induced Sweet syndrome and the most frequently implicated is granulocyte-colony stimulating factor. 5 We report a case of drug-induced Sweet syndrome in which lamotrigine was the main suspect drug, with excellent response to drug discontinuation.…”

Section: Introductionmentioning

confidence: 99%

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Lamotrigine-induced Sweet syndrome: Possible new drug association

et al. 2020

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Section: Discussionsupporting

confidence: 68%

Section: Introductionmentioning

confidence: 99%

Lamotrigine-induced Sweet syndrome: Possible new drug association

et al. 2020

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“…During the years, BS has been classified among spondyloarthropathies (2), autoinflammatory disorders (3), and more recently as a systemic vasculitis (4). However, BS is considered by some authors a neutrophilic dermatosis, not only for the muco-cutaneous aspects, but mainly for the presence of an intense neutrophilic infiltrate at histological level (5). Indeed, neutrophils are the main cells infiltrating not only oral and genital ulcers or erythema nodosum, but also other sites (i.e., eyes, central nervous system, vessel wall) (6, 7).…”

Section: Introductionmentioning

confidence: 99%

Behçet's Syndrome as a Model of Thrombo-Inflammation: The Role of Neutrophils

et al. 2019

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Behçet's syndrome (BS) is a systemic vasculitis, clinically characterized by different organ involvement and often complicated by thrombosis which occurs in vessels of all sizes. Thrombosis is more frequent in male patients with active disease and represents an important cause of morbidity and mortality. Neutrophil involvement in BS has been repeatedly suggested in the last few years. Indeed, neutrophils have been shown to be hyperactivated in BS patients, probably with a HLAB51 related contribution, and represent the main cells infiltrating not only oral and genital ulcers or erythema nodosum, but also other sites. Besides being deputed to host defense against micro-organisms, neutrophils display fundamental roles both in inflammation and tissue damage becoming inappropriately activated by cytokines, chemokines and autoantibodies and subsequently producing large amounts of superoxide anion ( ) via NADPH oxidase (NOX2). The strict relationship between inflammation and hemostasis has been already demonstrated. Indeed, inflammation and immune-mediated disorders increase the risk of thrombosis, but the pathways that link these processes have not been completely elucidated. In this regard, we recently demonstrated, in a large population of BS patients, a new neutrophil-dependent pathogenetic mechanism of thrombosis. In particular, it was shown that neutrophils, mainly through NADPH oxidase, produce excessive amounts of reactive oxygen species (ROS), which are able to markedly modify the secondary structure of fibrinogen and hence the overall architecture of the fibrin clot that becomes less susceptible to plasmin-induced lysis. These data point out that BS represents “ per se ” a model of inflammation-induced thrombosis and suggest that neutrophils specifically contribute to thrombo-inflammation in this rare disease. In particular, it is suggested that an alteration in fibrinogen structure and function are associated with enhanced ROS production via neutrophil NADPH oxidase. Altogether, these findings improve our understanding of the intricate pathogenetic mechanisms of thrombo-inflammation and may indicate potential new therapeutic targets.

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“…This finding is more characteristic of hidradenitis suppurativa and other disorders of follicular occlusion.Neutrophils infiltrating the eccrine gland secretory coils and vacuolar degeneration of secretory cells – Correct. The diagnosis of NEH is histologic and is defined by a neutrophilic infiltrate in and around the eccrine glands with concurrent necrosis of the secretory cells, as seen in Fig 2 5 Dense neutrophilic infiltrate of the dermis with sparing of the epidermis and leukocytoclasia – Incorrect.…”

Section: Case Presentationmentioning

confidence: 99%