Neutrophilic cholangitis in psoriasis vulgaris and psoriatic arthritis

Dieudé, Philippe; Sbidian, É.; Viguier, Manuelle; Zafrani, Elie‐Serge; Bazelaire, C. de; Dawidowicz, Karen; Adle‐Biassette, Homa; Allez, Matthieu; Petit, Arnaud; Richette, Pascal; Bachelez, Hervé

doi:10.1111/j.1365-2133.2012.11157.x

Cited by 12 publications

(15 citation statements)

References 8 publications

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“…The outlined findings in MRCP were similar to the key MRCP features described in patients with generalized pustular psoriasis and neutrophilic cholangitis as well as in patients with neutrophilic cholangitis and psoriasis vulgaris or psoriatic arthritis [1] [4] [5].…”

Section: Discussionsupporting

confidence: 54%

“…In a synopsis of these findings, Interleukin-8 may play a role in the pathogenesis of neutrophilic cholangitis occurring in patients with psoriasis [1].…”

Section: Discussionmentioning

confidence: 99%

“…The parallel course of liver abnormalities, parameters of cholestasis and psoriasis flares, as well as a negative search for any hepatotoxic drug intake, autoantibodies or viral hepatitis infection, negative history of alcohol misuse and the results of MRCP all reinforced a suspicion of neutrophilic cholangitis [1]. The outlined findings in MRCP were similar to the key MRCP features described in patients with generalized pustular psoriasis and neutrophilic cholangitis as well as in patients with neutrophilic cholangitis and psoriasis vulgaris or psoriatic arthritis [1] [4] [5].…”

Section: Discussionmentioning

confidence: 99%

“…MRCP results have been recognized as acceptable criteria, although liver histology remains the gold standard for a diagnosis of neutrophilic cholangitis [1].…”

Section: Discussionmentioning

confidence: 99%

“…To date no case of neutrophilic cholangitis as an elicitor of cholangiosepsis has been reported. Neutrophilic cholangitis is often found in combination with skin diseases with intense cutaneous infiltration with polymorphonuclear leucocytes and peripheral blood neutrophilia [1].…”

Section: Discussionmentioning

confidence: 99%

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Cholangiosepsis Caused by Neutrophilic Cholangitis in Plaque Psoriasis

Bergthaler¹,

Kramer²,

Steiner³

et al. 2016

JCDSA

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Psoriasis is a common inflammatory skin disease with many comorbid conditions. We present a 37-year-old male patient with a history of plaque psoriasis, status febrilis, violent umbilical pain, elevated inflammatory markers and liver parameters. Blood cultures were tested positive for E. coli. Diagnostic findings indicated that mechanical icterus and cholangiosepsis in the context of neutrophilic cholangitis were caused by inflammatory stenosis. Neutrophilic cholangitis is often found in combination with skin diseases with intense cutaneous infiltration with polymorphonuclear leucocytes and peripherial blood neutrophilia. Interleukin-8 may play a role in the pathogenesis of neutrophilic cholangitis occurring in patients with psoriasis [1]. We showed that complications of psoriasis can also occur at unusual locations. To date no case of neutrophilic cholangitis as an elicitor of cholangiosepsis has been reported.

show abstract

Section: Discussionsupporting

confidence: 54%

“…In a synopsis of these findings, Interleukin-8 may play a role in the pathogenesis of neutrophilic cholangitis occurring in patients with psoriasis [1].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…MRCP results have been recognized as acceptable criteria, although liver histology remains the gold standard for a diagnosis of neutrophilic cholangitis [1].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Cholangiosepsis Caused by Neutrophilic Cholangitis in Plaque Psoriasis

Bergthaler¹,

Kramer²,

Steiner³

et al. 2016

JCDSA

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show abstract

Psoriasis and Related Disorders

Burden

Kirby

2016

Rook's Textbook of Dermatology, Ninth Edition

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Psoriasis encompasses a group of related immune‐mediated inflammatory skin diseases that affect up to 3% of the population. These diseases are heritable and over 40 genetic susceptibility loci have been identified, many of which are involved in antigen presentation, cytokine signalling or innate antimicrobial responses. The commonest presentation of psoriasis is plaque psoriasis but the disease is clinically hetereogeneous in its manifestations and natural history depending on the age of the patient, environmental triggers and the sites affected. Distinct but related phenotypes include psoriatic arthritis, palmoplantar pustulosis and generalized pustular psoriasis. Psoriasis is associated with co‐morbidities including obesity, diabetes, vascular disease, depression and inflammatory bowel disease, which contribute to the considerable morbidity and increased mortality. Treatments include topical agents for disease of limited extent, phototherapy (UVB, PUVA) and systemic therapy (methotrexate, ciclosporin, acitretin, fumarates) for more extensive disease, and biological treatment (tumour necrosis factor α inhibitors, ustekinumab) for severe resistant psoriasis.

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Psoriasis and Related Disorders

Kirby,

Burden

2024

Rook's Textbook of Dermatology

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Neutrophilic cholangitis in psoriasis vulgaris and psoriatic arthritis

Cited by 12 publications

References 8 publications

Cholangiosepsis Caused by Neutrophilic Cholangitis in Plaque Psoriasis

Cholangiosepsis Caused by Neutrophilic Cholangitis in Plaque Psoriasis

Psoriasis and Related Disorders

Psoriasis and Related Disorders

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