Neutrophil β2 integrins: moderators of life or death decisions

Mayadas, Tanya N.; Culleré, Xavier

doi:10.1016/j.it.2005.05.002

Cited by 240 publications

(216 citation statements)

References 70 publications

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“…The finding that ␤-integrin is among the CvGal1 ligands on the hemocyte surface is intriguing, because in mammals this transmembrane signaling glycoprotein is not only a recognized galectin ligand (56) but is also pivotal in cell activation processes (57,58). The binding of galectins to the cell surface can form multivalent complexes (lattices) with cell surface glycoconjugate, and deliver a variety of intracellular signals to modulate cell activation, differentiation, and survival (59).…”

Section: Discussionmentioning

confidence: 99%

The Galectin CvGal1 from the Eastern Oyster (Crassostrea virginica) Binds to Blood Group A Oligosaccharides on the Hemocyte Surface*

Feng

Ghosh

Amin

et al. 2013

Journal of Biological Chemistry

120

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Background:The carbohydrate specificity of the oyster galectin CvGal1 for endogenous and exogenous glycans was unresolved. Results: CvGal1 recognizes blood group A tetrasaccharides on oyster hemocytes, which are absent on the surface of the P. marinus parasite. Conclusion: Oyster hemocytes and P. marinus display structurally distinct ligands for CvGal1. Significance: Galectins may function as pattern recognition receptors by binding microbial glycans structurally different from endogenous ligands.

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Section: Discussionmentioning

confidence: 99%

The Galectin CvGal1 from the Eastern Oyster (Crassostrea virginica) Binds to Blood Group A Oligosaccharides on the Hemocyte Surface*

Feng

Ghosh

Amin

et al. 2013

Journal of Biological Chemistry

120

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“…This may be related to the failure of C3H mice to control Cm infection. In addition to promoting neutrophil recruitment into inflamed tissue and pathogen phagocytosis, more recent data suggest that CD11b/CD18 also modulate neutrophil apoptosis (29,30). Mac-1-dependent phagocytosis of complement-opsonized pathogens triggers rapid neutrophil apoptosis.…”

Section: Discussionmentioning

confidence: 99%

Inefficiency of C3H/HeN Mice to Control Chlamydial Lung Infection Correlates with Downregulation of Neutrophil Activation During the Late Stage of Infection

Tang

Zhang

et al. 2009

Cell Mol Immunol

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We previously reported that massive infiltration of neutrophils in C3H/HeN (C3H) mice could not efficiently control Chlamydia muridarum (Cm) infection and might contribute to the high susceptibility of these mice to lung infection. To further define the nature of neutrophil responses in C3H mice during chlamydial infection, we examine the expression of adhesion molecules and CD11b related to neutrophils infiltration and activation, respectively, following intranasal Cm infection. The results showed that the expression of selectins (E-selectin, P-selectin and L-selectin), and intercellular cell adhesion molecule-1 (ICAM-1) in the lung of C3H mice increased more significantly than in C57BL/6 (B6) mice, the more resistant strain. These results correlated well with the massive neutrophils infiltration in C3H mice. In contrast, CD11b expression on peripheral blood and lung neutrophils in C3H mice exhibited a significant reduction compared with B6 mice during the late phage of infection (day 14). These findings suggest that the high-level expression of adhesion molecules in C3H mice may enhance neutrophils recruitment to the lung, but the decline of CD11b expression on neutrophils may attenuate neutrophil function. Therefore, CD11b down-regulation on neutrophils may contribute to the failure of C3H mice to control chlamydial lung infection. Cellular & Molecular Immunology. 2009;6(4):253-260.

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“…40 Neutrophils express the ␤ 2 -integrins ␣ L ␤ 2 (LFA-1), ␣ M ␤ 2 (Mac-1), ␣ x ␤ 2 , and low levels of ␣ 4 ␤ 1 . These integrins are involved in slow rolling, 6 adhesion, 40 postadhesion strengthening, 9 neutrophil migration, 41 respiratory burst, 42 phagocytosis, 43 and polarization and are a linkage between extracellular matrix and cytoskeleton. 44 Binding of integrins to their ligands induces outside-in signaling with a concomitant activation of several intracellular signaling pathways.…”

Section: Integrinsmentioning

confidence: 99%

“…Mac-1 engagement is necessary for oxidative burst 42 and phagocytosis. 43 The extracellular domain of the ␣-chain of LFA-1 (␣ L ) contains seven N-terminal homogeneous repeats organized into a ␤-propeller structure. The I domain is inserted in the third repeat and consists of two distinct sites: the metal ion-dependent adhesion site and the I-domain allosteric site.…”

Section: Integrinsmentioning

confidence: 99%

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Mechanisms and Consequences of Neutrophil Interaction with the Endothelium

Zarbock

Ley

2008

The American Journal of Pathology

196

119

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Leukocyte recruitment into inflamed tissue proceeds in a cascade-like fashion. The first contact of neutrophils with the endothelium is mediated by selectins and their counterreceptors, followed by rolling of neutrophils along the endothelial wall of postcapillary venules and integrin-mediated arrest. While rolling, neutrophils collect different inflammatory signals that can activate several pathways. In addition to activation of neutrophils by ligation of G-protein-coupled receptors with chemokines and other chemoattractants, integrins and selectin ligands are also able to signal into the cell, where they initiate neutrophil extravasation, promote cytoskeletal rearrangement, and ultimately induce superoxide production and degranulation. These signaling pathways may be targeted by therapeutic interventions to inhibit specific functions of neutrophils without affecting others. This Review is focused on the signaling events during the interaction of neutrophils with the endothelium.

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Neutrophil β2 integrins: moderators of life or death decisions

Cited by 240 publications

References 70 publications

The Galectin CvGal1 from the Eastern Oyster (Crassostrea virginica) Binds to Blood Group A Oligosaccharides on the Hemocyte Surface*

The Galectin CvGal1 from the Eastern Oyster (Crassostrea virginica) Binds to Blood Group A Oligosaccharides on the Hemocyte Surface*

Inefficiency of C3H/HeN Mice to Control Chlamydial Lung Infection Correlates with Downregulation of Neutrophil Activation During the Late Stage of Infection

Mechanisms and Consequences of Neutrophil Interaction with the Endothelium

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