Neutrophil-to-lymphocyte ratios and platelet-to-lymphocyte ratios in juvenile systemic lupus erythematosus: correlation with disease manifestations

Li, Wengen; Liu, Sudong; Chen, Chao; Yan-ying, Han

doi:10.21037/apm-21-1995

Cited by 6 publications

(5 citation statements)

References 33 publications

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“…Additionally, NLR has been associated with severe depression and poor/fair self-rated health in SLE [32] and to be a better marker than SIRI in predicting nephritis [33]. Another report has demonstrated that NLR had correlations with serological indicators and may predict organ involvement in juvenile SLE, particularly cutaneous, arthritis, serositis, and hematological involvement [34]. An NLR cut off value of 2.94 has been proposed to determine active disease of SLE [35].…”

Section: Discussionmentioning

confidence: 99%

Blood Composite Scores in Patients with Systemic Lupus Erythematosus

Mercader-Salvans,

García-González,

Quevedo-Abeledo

et al. 2023

Biomedicines

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Complete blood count-derived ratios have been described as inflammatory biomarkers in several diseases. These hematological scores include the neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammatory index ([SIRI]; neutrophils × monocytes/lymphocytes). Our aim was to study how these biomarkers are related to disease expression in a large and well-characterized series of patients with systemic lupus erythematosus (SLE). A total of 284 SLE patients and 181 age- and sex-matched healthy controls were recruited. The NLR, MLR, PLR, and SIRI were calculated, and activity (SLEDAI-2K), severity (Katz), and damage index (SLICC-DI) scores were assessed in patients with SLE. Multivariable linear regression analysis was performed to study whether these scores differ between patients and controls and how they are related to clinical and laboratory features of the disease. Crude cell counts of neutrophils, monocytes, lymphocytes, and platelets were lower in SLE patients compared to controls. Despite this, NLR, MLR, and PRL, but not SIRI, were higher in SLE patients than in controls after multivariable analysis. However, the relationship between the different scores and disease characteristics was limited. Only the Katz severity index revealed a significant positive relationship with SIRI, NLR, and MLR after adjustment for covariates. Similarly, alternative complement cascade activation and low C3 were significantly associated with higher NLR, MLR, and PLR. In conclusion, although cytopenias are a common feature of patients with SLE, hematologic composite scores are independently higher in this population compared to controls. However, the relationship of these scores with the characteristics of the disease is scarce, with the relationship with the complement system being the most consistent.

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Section: Discussionmentioning

confidence: 99%

Blood Composite Scores in Patients with Systemic Lupus Erythematosus

Mercader-Salvans,

García-González,

Quevedo-Abeledo

et al. 2023

Biomedicines

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“…A component of the routine blood cell examination (RBC), NLR values have attracted increased attention in recent years for their utility in inflammatory and autoimmune disease. Previous work has indicated that NLR reflects disease activity in rheumatoid arthritis (RA) [ 11 ] and Bechet disease (BD) [ 12 , 13 ], is a predictive marker for psoriatic arthritis (PsA) [ 14 ] and relates to the occurrence of lupus nephritis in systemic lupus erythematosus (SLE) [ 15 , 16 ]. However, to the best of our knowledge, the relationship between NLR and MDA5 + DM has not been previously studied.…”

Section: Discussionmentioning

confidence: 99%

Neutrophil-to-lymphocyte ratio is a predictive marker for anti-MDA5 positive dermatomyositis

Liu

Zhang

et al. 2022

BMC Pulm Med

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Background NLR is a systemic inflammatory marker that have been associated with overall survival in patients with some rapidly progressive disease. There are few data about the diagnostic and predictive value of NLR in autoimmune diseases, and it has not been described in anti-MDA5 positive DM. We try to correlate neutrophil-to-lymphocyte ratio (NLR) with fatality from dermatomyositis in anti-MDA5 positive patients. Method A retrospective study in which 195 patients were enrolled was conducted. Clinical and laboratory information was collated and ratios of neutrophil to lymphocyte counts (NLR) calculated. The primary end point was all-cause death. Result Of the 195 patients studied, all had interstitial lung disease, including 140 survivors and 55 non-survivors. An optimal NLR cut-off value of 4.86 for mortality prediction was identified. The NLR of non-survivors was significantly higher than that of survivors (p < 0.001). Plasma levels of lactate dehydrogenase (LDH) and C-reactive protein were significantly increased when NLR was greater than 4.86. Results of multivariate analysis established that NLR > 4.86 was an independent predictor of mortality (HR: 2.52; 95%CI: 1.33–4.78; p = 0.005). Abstinence from smoking (HR: 2.66; 95%CI: 1.33–4.78; p = 0.003), emergence of rapidly progressive interstitial lung disease (RPILD; HR: 4.38; 95%CI: 2.37–8.08; p < 0.001), low plasma LDH (HR: 3.82; 95%CI: 2.06–7.11; p < 0.001) and presentation with dyspnea (HR: 2.17; 95%CI: 1.22–3.86; p = 0.009) were all protective factors predictive of survival. Conclusion NLR is a cost-effective and widely accessible biomarker with utility for risk stratification in patients with anti-MDA5 + dermatomyositis.

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“…Kết quả này phù hợp về mặt dịch tễ học khi mà tỷ lệ mắc bệnh LBĐHT ở nữ cao hơn so với nam giới, thường là 8/1 [9]. Kết quả này cũng tương đồng với tác giả Nguyễn Hữu Trường (2017) khi nghiên cứu trên 128 bệnh nhân LBĐHT cho thấy tỷ lệ nữ/nam = 13,2/1 [10], Wengen Li và cộng sự (2021), Hyoun-Ah Kim và cộng sự (2017), Yunxiu Wu và cộng sự (2016) cho thấy tỷ lệ nữ/nam ở nhóm bệnh LBĐHT lần lượt là 6,8/1 (n = 186) [11], 12,3 (n = 120) [3], 5,1 (n = 116) [7]. Sự khác biệt về tỷ lệ nữ/ nam giữa các nghiên cứu có thể do sự khác biệt về chủng tộc (Việt Nam, Trung Quốc, Hàn Quốc).…”

Section: Bàn Luận 41 đặC đIểm Chung Của đốI Tượng Nghiên Cứu 411 đ...unclassified

“…Kết quả nghiên cứu trên khá tương đồng với nghiên cứu của Yunxiu Wu và cộng sự (2016) khi cho biết NLR có mối tương quan thuận với PLR (r = 0,584, p < 0,001), số lượng bạch cầu chung (r = 0,488, p < 0,001), NEU (r = 0,708, p < 0,001), highsensitivity CRP (r = 0,356, p < 0,001) nhưng lại tương quan nghịch với LYM (r = -0,447, p < 0,001), C3 (r = -0,218, p = 0,027) và C4 (r = -0,211, p = 0,033) [7]. Nghiên cứu của Wengen Li và cộng sự (2021) thấy sự tương quan thuận của NLR với viêm thanh mạc (r = 0,153, p = 0,037), C3 (r = 0,152, p = 0,038) và C4 (r = 0,177, p = 0,016); PLR có tương quan thuận với ban ở da (r = 0,227, p = 0,002), viêm khớp (r = 0,290, p < 0,001), kháng thế anti-Sm (r = 0,20, p = 0,006) và tốc độ lắng máu (r = 0,159, p = 0,03) [11]. Tác giá Mona M. và cộng sự (2020) thì không cho thấy có mối tương quan giữa NLR với C3, C4 nhưng lại có sự tương quan thuận với ure máu (r = 0,44, p = 0,004) và creatinin (r = 0,32, p < 0,001); PLR có tương quan nghịch với C4 (r = -0,48, p = 0,02) [15].…”

Section: Tương Quan Giữa Các Chỉ Số Huyết Học ở Bệnh Nhân Lupus Ban...unclassified

Research of neutrophil-to-lymphocyte ratios and platelet-tolymphocyte ratios in systemic lupus erythematosus in Hue University of Medicine and Pharmacy Hospital

Hoang Thi Anh,

Nguyen Dac Duy,

Hoang Thi Thanh

et al. 2023

JMP

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Background: Systemic lupus erythematosus (SLE) is a chronic systemic inflammatory autoimmune disease and has various clinical manifestations affecting organ systems. It is characterized by the deposition of immune complexes due to widespread loss of immune tolerance to nuclear self-antigens, as well as excessive proinflammatory cytokine production. The neutrophil-to-lymphocyte ratios (NLR) and platelet-tolymphocyte ratio (PLR) in SLE are often higher than in the normal population, which is significantly related to disease progression and is an indicator of monitoring disease activity. Therefore, the study was conducted with the aim of understanding the change of some hematological indexes in patients with SLE. Materials and method: The study was conducted on 51 patients with newly diagnosed SLE at the Department of General Internal Medicine - Endocrinology - Musculoskeletal and a control group of 30 healthy people who came to the hospital of Hue University of Medicine and Pharmacy from June 2022 to March 2023. Results: The NLR and PLR of SLE patients were significantly higher compared to those of the controls (p < 0.001 and p < 0.012, respectively). Based on the ROC curve, the best NLR cut-off value to predict SLE was 1.7 with 58.8% sensitivity and 70.0% specificity. NLR was positively correlated with PLR (r = 0.735, p < 0.001) and white blood cells (r = 0.532, p < 0.001). Conclusion: The NLR index can be a useful marker in the assessment of inflammation in patients with SLE Key words: Systemic lupus erythematosus, NLR, PLR.

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Neutrophil-to-lymphocyte ratios and platelet-to-lymphocyte ratios in juvenile systemic lupus erythematosus: correlation with disease manifestations

Cited by 6 publications

References 33 publications

Blood Composite Scores in Patients with Systemic Lupus Erythematosus

Blood Composite Scores in Patients with Systemic Lupus Erythematosus

Neutrophil-to-lymphocyte ratio is a predictive marker for anti-MDA5 positive dermatomyositis

Research of neutrophil-to-lymphocyte ratios and platelet-tolymphocyte ratios in systemic lupus erythematosus in Hue University of Medicine and Pharmacy Hospital

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