Neutrophil to Lymphocyte Ratio Predicts Poor Prognosis in Ischemic Cerebrovascular Disease

Çelikbilek, Asuman; İsmailoğulları, Sevda; Zararsız, Gökmen

doi:10.1002/jcla.21639

Cited by 150 publications

(138 citation statements)

References 18 publications

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“…Furthermore, the NLR has been reported to be an independent risk factor for the incidence of AIS in generally healthy populations [2]. In our study, the NLR and the total WBC count were significantly higher in the poor outcome group than in the good outcome group, similar to results reported in other studies [23,24,[32][33][34]. This result remains significant even after adjustment for various potential confounders.…”

Section: Discussionsupporting

confidence: 90%

“…Lately, the NLR has been reported as an independent predictor of the severity and mortality of acute coronary syndrome [17][18][19][20][21][22][23]. Several studies have supported the hypothesis that the NLR is an independent factor for predicting short-term mortality and unfavorable functional outcome in AIS [23,24,32,34,41]. Tokgoz et al reported that the NLR at the time of hospital admission might be a predictor of short-term mortality independent of infarct volume in patients with AIS [42].…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have attempted to determine the relationship between the NLR and stroke subtype [23,33,41,43,44]. Most reports have produced consistent results indicating that lacunar stroke is associated with a lower NLR, and that large artery disease is associated with a higher NLR.…”

Section: Discussionmentioning

confidence: 99%

“…An increase in the NLR has been shown to increase in-hospital mortality and morbidity in patients with acute coronary syndrome [17]. Recent studies have shown that the NLR provides a reliable inflammatory index that can be used for prognostic stratification in cardiovascular events [17][18][19][20][21][22][23]. However, the effects of the NLR on short-term functional outcome in AIS are still uncertain and few studies have been conducted [24].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Neutrophil to Lymphocyte Ratio Predicts Short-Term Functional Outcome in Acute Ischemic Stroke

2017

ARC Journal of Neuroscience

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Neutrophil to Lymphocyte Ratio Predicts Short-Term Functional Outcome in Acute Ischemic Stroke

2017

ARC Journal of Neuroscience

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“…In addition, it is used to predict the prognosis of patients with various cancers [10,11], cardiovascular diseases [12,13] and hemorrhagic stroke [14][15][16]. Recently, NLR was used to predict in-hospital mortality [17,18], 90-day mortality [19][20][21] and 90-day poor outcomes (mRS≥3) [4,[21][22][23] in patients with ischemic stroke.…”

Section: Introductionmentioning

confidence: 99%

The prediction of neutrophil to lymphocyte ratio for outcomes in ischemic stroke

Ye¹,

Ai²,

Fang³

et al. 2017

Oncotarget

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Objective: Neutrophil to lymphocyte ratio (NLR) is a prognostic inflammatory biomarker in patients with cardiovascular disease and hemorrhagic stroke. This metaanalysis aims to evaluate the prognostic values of NLR in predicting clinical outcomes in patients with ischemic stroke.Methods: A literature search was performed using the databases PubMed, EMBASE, Cochrane Central Register of Controlled Trials and China National Knowledge Infrastructure. Two reviewers independently retrieved papers that met the inclusion criteria. Subgroup analyses were performed using in-hospital mortality, 90-day mortality and 90-day poor outcomes (mRS>2) as the outcome measures.Results: Eight studies with 3855 patients were included in the analysis. An elevated NLR was a strong predictor for in-hospital mortality (OR: 1.05; 95% CI: 1.03-1.07, p<0.001) and for 90-day poor outcomes (OR: 2.28; 95% CI: 1.39-3.73, p<0.001), but not for 90-day mortality (OR: 3.04; 95% CI: 0.74-12.55, p=0.12). After performing subgroup analysis, the NLR was found to predict 90-day mortality with a high (>5) cut-off values (OR: 6.69; 95% CI: 1.70-26.33, p=0.007). The lower cut-off values had no significance (OR: 2.17; 95% CI: 0.43-10.86, p=0.35).Conclusions: A high NLR was significantly associated with higher rates of inhospital mortality and 90-day poor outcome in patients with ischemic stroke, especially with a high mean NLR or high cut-off values. With a high cut-off value (>5), NLR could predict the 90-day mortality after ischemic stroke.

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Neutrophil–lymphocyte ratio predicts post‐thrombolysis early neurological deterioration in acute ischemic stroke patients

et al. 2019

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Background and purpose Intravenous thrombolysis (IVT) has become the standard treatment for acute ischemic stroke within 4.5 hr after symptoms onset. However, a fraction of patients would develop early neurological deterioration (END) after IVT. The aim of our study was to explore the utility of neutrophil–lymphocyte ratio (NLR) in predicting END. Methods From October 2016 to March 2018, 342 consecutive patients with thrombolytic therapy were prospectively enrolled in this study. Blood cell counts were sampled in stroke emergency room before IVT. END was defined as a National Institutes of Health Stroke Scale score increase of ≥4 points within 24 hr after IVT. Multiple regression analysis was used to investigate the potential risk factors of END. We also performed receiver operating characteristic curve analysis and nomogram analysis to assess the overall discriminative ability of the NLR in predicting END. Results Of the 342 patients, 86 (25.1%) participants were identified with END. Univariate logistic regression analysis demonstrated that patients with NLR in the third tertile, compared with the first tertile, were more likely to have END (odds ratio, 9.783; 95% confidence interval [CI], 4.847–19.764; p = .001). The association remained significant even after controlled for potential confounders. Also, a cutoff value of 4.43 for NLR was detected in predicting post‐thrombolysis END with a sensitivity of 70.9% and a specificity of 79.3% (area under curve, 0.779; 95% CI, 0.731–0.822). Furthermore, our established nomogram indicated that higher NLR was an indicator of post‐thrombolysis END (c‐index was 0.789, p < .001). Conclusions This study showed that elevated level of NLR may predict post‐thrombolysis END in ischemic stroke patients.

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Neutrophil to Lymphocyte Ratio Predicts Poor Prognosis in Ischemic Cerebrovascular Disease

Abstract: These findings support the role of N/L ratio as a simple inexpensive and readily available marker of prognosis in acute ischemic stroke.

Cited by 150 publications

References 18 publications

Neutrophil to Lymphocyte Ratio Predicts Short-Term Functional Outcome in Acute Ischemic Stroke

Neutrophil to Lymphocyte Ratio Predicts Short-Term Functional Outcome in Acute Ischemic Stroke

The prediction of neutrophil to lymphocyte ratio for outcomes in ischemic stroke

Neutrophil–lymphocyte ratio predicts post‐thrombolysis early neurological deterioration in acute ischemic stroke patients

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