Neutrophil to Lymphocyte Ratio on Appendectomy of Geriatric and Nongeriatric Patients

Çığşar, Gülşen; Demiray, Emine Kübra Dindar; Anuk, Turgut; Güzel, Hatice; Günal, Elnare; Gülkan, Saygı; İrem, Burak; Bilgin, Caglar

doi:10.1080/08941939.2016.1241324

Cited by 13 publications

(13 citation statements)

References 21 publications

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“…The NLR as an inflammatory marker has proven its association with complications and long-term outcome in the setting of gastro-intestinal pathologies treated medically or surgically [ 6 , 9 – 11 ]. The NLR has also been associated with complications after major cardiac events or in a variety of cancers [ 12 , 13 ].…”

Section: Discussionmentioning

confidence: 99%

Prediction of postoperative mortality in elderly patient with hip fractures: a single-centre, retrospective cohort study

et al. 2018

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BackgroundElderly patients are at high risk for postoperative complications and increased mortality after hip fracture (HF) surgery due to frailty and co-morbidities. The prediction of postoperative outcome could be used for clinical decision making. A reliable score to predict postoperative mortality after HF surgery in this sub-population remains unavailable.MethodsA single-centre retrospective cohort study was performed in 782 patients who were operated on for HF. Receiver Operating Characteristic (ROC)-curves were used to analyse the performance of gender, age, neutrophil-to-lymphocyte ratio (NLR) and C-reactive protein (CRP) at admission (D0) as prognostic factors, alone or combined with the PreOperative Score to predict PostOperative Mortality (POSPOM) in univariate and multivariate linear regression models.ResultsNo correlation between gender, age, NLR D0 or CRP D0 and postoperative, intra-hospital mortality was found. The Area Under the ROC-curve (AUC) for age, male gender, NLR and CRP were 0.61 [95% confidence interval (CI) = 0.45–0.61], 0.56 [95% CI = 0.42–0.56], 0.47 [95% CI = 0.29–0.47] and 0.49 [95% CI = 0.31–0.49] respectively. Combination with the POSPOM score did not increase its discriminative capacity as neither age (AUC = 0.69, 95% CI = 0.54–0.69), gender (AUC = 0.72, 95% CI = 0.58–0.72), NLR D0 (AUC = 0.71, 95% CI = 0.56–0.71), nor the CRP D0 (AUC = 0.71, 95% CI = 0.58–0.71) improved the POSPOM performance.ConclusionsNeither age, gender, NLR D0 nor CRP D0 are suitable parameters to predict postoperative, intra-hospital mortality in elderly patients undergoing surgery for HF.

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Section: Discussionmentioning

confidence: 99%

Prediction of postoperative mortality in elderly patient with hip fractures: a single-centre, retrospective cohort study

et al. 2018

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“…White blood cell count (WBC) is studied well in the literature, but recently, there are several CBC parameters such as red blood cell distribution width (RDW), mean platelet volume (MPV), and platelet distribution width (PDW) associated with the diagnosis of appendicitis (8)(9)(10)(11). In recent studies, neutrophil-to-lymphocyte ratio (NLR) is reported associated with several surgical clinical conditions as appendicitis, acute mesenteric ischemia, and strangulated inguinal hernia (12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

Investigation of the Diagnostic Value of Neutrophil to Lymphocyte Ratio in Pediatric Appendicitis Cases

Yılmaz

Acar

2017

Iran J Pediatr

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“…They found that diagnostic values for diagnosing acute appendicitis were increased when the cut-off value decreased (32) . Cigsar et al found the cut-off value of NLR as 4.9 by the evaluation of ROC curve analysis in their series, the sensitivity and specificity were found to be 73% (33) . In our study, when the cut-off value was taken as 5.80 in the group of patients who were aged 60 years and older, the sensitivity was found to be 69.1%, specificity was 52.7%, the positive predictive value was 70.2% and the negative predictive value was calculated as 52.3%.…”

Section: Discussionmentioning

confidence: 92%

Predictive Value of Neutrophil/Lymphocyte Ratios in the Diagnosis of Acute Appendicitis

Akyüz¹,

Topal²,

Gök³

et al. 2020

BMJ

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Objective: The debate on the value of laboratory tests in the diagnosis of acute appendicitis (AA) continues. In this study, we aimed to evaluate the blood count parameters and the diagnostic value of neutrophil/lymphocyte ratio in the diagnosis of acute appendicitis. Method: 851 patients who underwent appendectomy under emergency conditions were included in the study. Patients were divided into 2 groups; Group 1 was negative appendectomy and Group 2 was acute appendicitis. In addition, they were divided into subgroups as 18-39 years, 40-59 years, and 60 years and older. Neutrophil, platelet, lymphocyte count and Neutrophil/lymphocyte ratio were compared in groups and subgroups. Results: There were 146 patients (17.1%) in Group 1 (negative appendectomy group) and 705 patients (82.9%) in Group 2 (acute appendicitis group). Male sex was dominant in Group 2 (p=0.049). Neutrophil count and neutrophil / lymphocyte ratio (NLR) were higher in Group 2 (p<0.001, p<0.001, respectively), whereas in Group 1, lymphocyte count and platelet count were higher (p=0.008, p=0.002, respectively). The cutoff value for NLR was found to be 5.29 in the ROC curve analysis.

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Neutrophil to Lymphocyte Ratio on Appendectomy of Geriatric and Nongeriatric Patients

Abstract: NLR could not predict positive appendectomy rates in the geriatric population but could in the nongeriatric patient group. To find the optimal NLR levels, prospective randomized studies are needed.

Cited by 13 publications

References 21 publications

Prediction of postoperative mortality in elderly patient with hip fractures: a single-centre, retrospective cohort study

Prediction of postoperative mortality in elderly patient with hip fractures: a single-centre, retrospective cohort study

Investigation of the Diagnostic Value of Neutrophil to Lymphocyte Ratio in Pediatric Appendicitis Cases

Predictive Value of Neutrophil/Lymphocyte Ratios in the Diagnosis of Acute Appendicitis

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