Neutrophil-to-lymphocyte ratio, nucleated red blood cells and erythrocyte abnormalities in canine systemic inflammatory response syndrome

Pierini, Alessio; Gori, Eleonora; Lippi, Ilaria; Ceccherini, Gianila; Lubas, George; Marchetti, Veronica

doi:10.1016/j.rvsc.2019.08.028

Cited by 38 publications

(57 citation statements)

References 22 publications

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“…Two recent studies investigated the NLR in SIRS and septic peritonitis in dogs. 10,11 Both studies found elevated NLRs during inflammatory processes but found no associations with the disease severity or course of disease. 10 The results of our study confirm that the NLR is increased in dogs and cats with pancreatitis compared with that of healthy controls.…”

Section: Discussionmentioning

confidence: 99%

“…In veterinary medicine, NLRs were investigated in some studies of dogs with septic peritonitis or systemic inflammatory response syndrome (SIRS). 10,11 They compared NLRs in dogs with sepsis, nonseptic systemic inflammatory disease, and controls. The conclusions about the use of the NLR as a prognostic marker in cases of severe inflammatory processes in dogs were different.…”

Section: Introductionmentioning

confidence: 99%

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Neutrophil‐to‐lymphocyte and platelet‐to‐lymphocyte ratios in dogs and cats with acute pancreatitis

Neumann

2021

Veterinary Clinical Pathol

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Background: Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been described as prognostic markers in cancer and inflammatory diseases. The use of these measurements in dogs and cats with acute pancreatitis has not yet been investigated. Objective: The objective was to evaluate NLR and PLR for usefulness as biomarkers for severity and clinical course of acute pancreatitis in dogs and cats. Methods: In this prospective study, we investigated 67 dogs and 41 cats with acute pancreatitis and 17 healthy dogs and cats as controls. We compared the NLR and PLR of dogs and cats with acute pancreatitis with control animals. The severity of disease was measured using a modified "bedside index of severity in acute pancreatitis" (BISAP) score in humans, and the course of the disease was measured with the time to clinical recovery. Results: NLR and PLR were significantly higher in dogs and cats with pancreatitis than in healthy controls. However, no significant relationship between NLR or PLR and disease severity was found, as assessed with the modified BISAP score. Dogs and cats with pancreatitis and prolonged recovery displayed a significantly increased PLR, and those same cats also displayed a significantly increased NLR. Conclusions: We conclude that increased NLR and PLR provide information regarding the course of pancreatitis in dogs and cats. How to cite this article: Neumann S. Neutrophil-tolymphocyte and platelet-to-lymphocyte ratios in dogs and cats with acute pancreatitis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Neutrophil‐to‐lymphocyte and platelet‐to‐lymphocyte ratios in dogs and cats with acute pancreatitis

Neumann

2021

Veterinary Clinical Pathol

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“…Likewise, humans affected by OSA also demonstrate higher N/L ratio, positively correlated to the OSA severity 48 and mitigated by continuous positive airway pressure (CPAP) therapy 48 , 49 . Furthermore, high N/L ratios were reported in dogs affected by systemic inflammatory response syndrome 50 and septic peritonitis 51 , but not yet described in brachycephalic dogs. Therefore, we considered the existence of a subacute inflammatory status on brachycephalic dogs, which corroborates previously evidence that this syndrome leads to systemic inflammatory derangements 10 , 52 , and probably to consequences such as observed in humans with OSA.…”

Section: Discussionmentioning

confidence: 92%

Liver and spleen elastography of dogs affected by brachycephalic obstructive airway syndrome and its correlation with clinical biomarkers

Facin

Uscátegui

Maronezi

et al. 2020

Sci Rep

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The purpose of this study is to determine whether the brachycephalic obstructive airway syndrome (BOAS) is correlated to alterations in liver and spleen elasticity. Forty-eight brachycephalic and 22 mesocephalic dogs were submitted to a BOAS functional assessment, laboratory tests, abdominal ultrasound and liver and spleen Acoustic Radiation Force Impulse (ARFI) elastography. Dogs clinically affected by BOAS had higher values of liver stiffness (p < 0.001) than healthy dogs: medial lobes (1.57 ± 0.37 m/s), left and right lateral lobes (1.54 ± 0.50 m/s, 1.23 ± 0.28 m/s, respectively) and caudate lobe (1.28 ± 0.42 m/s). Compared to the mesocephalic group, the brachycephalic group (BOAS clinically affected and unaffected dogs) had higher spleen (2.51 ± 0.45 m/s; p < 0.001) and liver stiffness (p < 0.001): medial lobes (1.53 ± 0.37 m/s), left and right lateral lobes (1.47 ± 0.47 m/s, 1.20 ± 0.30 m/s, respectively) and caudate lobe (1.23 ± 0.40 m/s). Principal component analysis explained 70% of the variances composed by liver stiffness increase, erythrocytes and alanine aminotransferase reduction. Brachycephalic dogs had higher spleen and liver stiffness and a subacute inflammatory state, which represent another BOAS systemic effect. Consequently, these dogs can be at higher risk of hepatic disorders compared with mesocephalic dogs, similarly to humans affected by sleep apnea syndrome.

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“…To the best of our knowledge, there are no specific studies on the NLR in canine IBD, as it has been evaluated only in oncological patients and in patients affected by septic peritonitis and systemic inflammatory response syndrome [ 18 , 19 , 20 , 21 , 22 , 23 ]. The aim of the study was therefore to evaluate the possible clinical significance of the NLR in dogs with IBD.…”

Section: Introductionmentioning

confidence: 99%

Neutrophil-to-Lymphocyte Ratio (NLR) in Canine Inflammatory Bowel Disease (IBD)

Benvenuti

Pierini

Gori

et al. 2020

Veterinary Sciences

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Inflammatory bowel disease (IBD) is a multifactorial chronic inflammatory disorder leading to structural changes in the intestinal wall. In humans, the neutrophil-to-lymphocyte ratio (NLR) has been proposed as a promising marker of IBD. This study evaluated the possible clinical and prognostic significance of the NLR in dogs with IBD. This retrospective study enrolled 41 dogs diagnosed with IBD presented to University of Pisa from January 2017 to January 2018. For each dog, age, sex, canine chronic enteropathy clinical activity index (CCECAI), endoscopic and histopathological grading were recorded. Complete blood count, serum total protein, albumin, cholesterol, and C-reactive protein at the time of endoscopy were recorded. A control group (CG) of healthy dogs from a blood donor database was built. NLR was calculated for both IBD and CG as the ratio between absolute neutrophils and lymphocytes. Presence of crypt distension, lacteal dilation (LD), mucosal fibrosis, intraepithelial lymphocytes was recorded. Follow-up information was obtained from electronic medical records and dogs were classified as responders and non-responders based on CCECAI variation between admission and the first recheck. IRE dogs showed higher NLR compared to healthy dogs. NLR correlated negatively with total protein, albumin, and cholesterol and correlated positively with CCECAI. Dogs with LD showed higher NLR than dogs without LD. Non-responders showed higher NLR compared to responders. In conclusion, as in IBD human patients, the NLR acts as an inflammatory marker providing further information on severity of the disease and could be useful in predicting treatment response.

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Neutrophil-to-lymphocyte ratio, nucleated red blood cells and erythrocyte abnormalities in canine systemic inflammatory response syndrome

Cited by 38 publications

References 22 publications

Neutrophil‐to‐lymphocyte and platelet‐to‐lymphocyte ratios in dogs and cats with acute pancreatitis

Neutrophil‐to‐lymphocyte and platelet‐to‐lymphocyte ratios in dogs and cats with acute pancreatitis

Liver and spleen elastography of dogs affected by brachycephalic obstructive airway syndrome and its correlation with clinical biomarkers

Neutrophil-to-Lymphocyte Ratio (NLR) in Canine Inflammatory Bowel Disease (IBD)

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