Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were associated with disease activity in patients with systemic lupus erythematosus

Yun-xiu, WU; Chen, Yanjuan; Yang, Xiaoguang; Chen, Li-Shu; Yang, Yihua

doi:10.1016/j.intimp.2016.04.006

Cited by 170 publications

(170 citation statements)

References 34 publications

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“…A meta-analysis including 3430 patients proved that an elevated PLR predicted poor OS and poor disease-free survival and progression-free survival in non-small cell lung cancer [30]. The prognostic value of the NLR and PLR in patients with lung cancer appears to have been established by our study and previous studies [12-22]. However, the cutoff value and prognostic effect of the NLR and PLR remain controversial.…”

Section: Discussionsupporting

confidence: 60%

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The Neutrophil to Lymphocyte Ratio May Predict Benefit from Chemotherapy in Lung Cancer

Liu

Jin

Zhang

et al. 2018

Cell Physiol Biochem

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Background/Aims: The objectives of this study were to evaluate the impact of the neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) on overall survival (OS) and to explore the value of changes in the NLR and PLR with treatment as a response indicator. Methods: A total of 934 patients were eligible for retrospective analysis between 2008 and 2014. The pretreatment and post-treatment PLR and NLR in all patients were calculated based on complete blood counts. Univariate and multivariate Cox regression analyses were performed to determine the associations of the PLR and NLR with OS. Results: The pretreatment NLR and PLR were correlated with different disease status and response to chemotherapy. Patients with lower NLR and PLR had a significantly better complete response (CR) rate to chemotherapy versus those with a higher NLR and PLR (p< 0.001). The NLR and PLR were sustained in patients who obtained a CR compared with moderate or poor response patients. The lower NLR of pretreatment was independently associated with a favourable prognosis in whole patients with lung cancer (HR: 0.69, 95% CI, 0.55-0.85, p< 0.001). In the patients under control after chemotherapy, the NLR of post-chemotherapy had a greater impact on survival, and the low NLR level maintained during chemotherapy was identified a predictor for favourable survival. PLR was not an independent prognostic indicator in the whole cohort or any subgroups. Conclusion: Our results suggested that NLR was well-connected with outcomes and response to chemotherapy in patients with lung cancer. As a response indicator, NLR may predict benefit from chemotherapy and improve patient selection.

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Section: Discussionsupporting

confidence: 60%

“…These ratios have shown prognostic relevance across a large variety of tumour types [7-12]. In lung cancer, a number of retrospective studies have estimated the prognostic significance of baseline NLR and PLR [12-22]. …”

Section: Introductionmentioning

confidence: 99%

The Neutrophil to Lymphocyte Ratio May Predict Benefit from Chemotherapy in Lung Cancer

Liu

Jin

Zhang

et al. 2018

Cell Physiol Biochem

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“…Preoperative platelet to lymphocyte ratio (PLR) and neutrophil to lymphocyte ratio (NLR) are two simply and widely available markers to reflect systemic inflammation status [10]. These two markers have been shown to be prognostic for several cancer types such as gastric, colorectal, liver and pancreatic cancers [9, 11–13].…”

Section: Introductionmentioning

confidence: 99%

Preoperative platelet to lymphocyte and neutrophil to lymphocyte ratios are independent prognostic factors for patients undergoing lung cancer radical surgery: A single institutional cohort study

et al. 2016

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BackgroundThe aim of this study was to assess the prognostic value for NSCLC patients who were scheduled to receive lung cancer radical resection.MethodsIn this cohort study (Dec.2014-Feb.2016), patients with non-small cell lung cancer (NSCLC) who underwent radical lung cancer thoracotomy were enrolled and accessed at postoperative complications, one-year overall survival (OS) and relapse-free survival (RFS). The preoperative PLR and NLR of all patients were calculated based on preoperative complete blood counts. Univariate and multivariate Cox regression analyses were performed to determine the associations of PLR and NLR with OS and RFS.ResultsA total of 174 NSCLC patients were studied. The results indicated that both high PLR (>148.6) and NLR (>2.9) were related to a high rate of postoperative pulmonary complications significantly (49.3%vs.29.1%, P = 0.007; 50.7% vs. 28.6%, P = 0.003). Moreover, NSCLC patients with a high PLR level (> 148.6) was significantly associated with a lower one-year OS (90.3% vs. 77.5%, P = 0.034).ConclusionsPreoperative PLR and NLR were good prognostic factors for postoperative pulmonary complications and OS in NSCLC patients undergoing radical lung cancer surgery. Thus, blood PLR and NLR would be helpful as a prognostic tool before radical lung cancer surgery.

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“…One of these was excluded because they included other diseases [31]. Thus, nine articles met the inclusion criteria [3,[10][11][12][13][14][15][16][17] (Table 1, Figure 1). One report contained data on two different groups [12], so we analyzed these studies independently.…”

Section: Studies Included In the Meta-analysismentioning

confidence: 99%

“…Studies on NLR, PLR, and MPV in SLE patients compared to healthy controls, on the relationship between NLR, PLR, and MPV levels and SLE activity, and on the association of NLR with renal involvement in SLE have reported controversial results [3,[10][11][12][13][14][15][16][17]. This may be because of the small sample sizes, low statistical power, and/or the presence of clinical heterogeneity.…”

Section: Introductionmentioning

confidence: 99%

Association of Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio, and Mean Platelet Volume with Systemic Lupus Erythematosus Disease Activity: A Meta-analysis

Lee

Song

2017

J Rheum Dis

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Objective. A series of common blood tests neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and mean platelet volume (MPV) could provide a measure of systemic lupus erythematosus (SLE) activity. Methods. We searched the Medline, Embase, and Cochrane databases and performed a meta-analysis comparing NLR, PLR, and MPV in patients with SLE to controls, and examined correlation coefficients between NLR, PLR, and MPV and SLE activity based on SLE Disease Activity Index (SLEDAI) using random-effects models. Results. Nine studies were included in this meta-analysis. Meta-analysis revealed that NLR was significantly higher in the SLE group than in the control group (standard mean difference [SMD]=2.747, 95% confidence interval [CI]=1.241∼4.254, p＜0.001). PLR was also significantly higher in the SLE group (SMD=1.564, 95% CI=0.122∼3.006, p=0.034). Meta-analysis of correlation coefficients showed that both NLR and PLR were positively associated with SLEDAI (correlation coefficient=0.404, 95% CI=0.299∼0.500, p＜0.001; correlation coefficient=0.378, 95% CI=0.234∼0.505, p＜0.001). The pooled sensitivity and specificity of NLR for diagnosis of lupus nephritis were 75.1% (95% CI, 68.5∼81.0) and 72.9% (95% CI, 64.9∼80.0), respectively. The area under the curve of NLR were 0.794. However, meta-analysis indicated no elevated MPV in the SLE group and no correlation between MPV and SLE activity. Conclusion. This meta-analysis demonstrated that both NLR and PLR are higher in patients with SLE, a significantly positive correlation exists between NLR/PLR and SLE activity. (J Rheum Dis 2017;24:279-286)

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Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were associated with disease activity in patients with systemic lupus erythematosus

Cited by 170 publications

References 34 publications

The Neutrophil to Lymphocyte Ratio May Predict Benefit from Chemotherapy in Lung Cancer

The Neutrophil to Lymphocyte Ratio May Predict Benefit from Chemotherapy in Lung Cancer

Preoperative platelet to lymphocyte and neutrophil to lymphocyte ratios are independent prognostic factors for patients undergoing lung cancer radical surgery: A single institutional cohort study

Association of Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio, and Mean Platelet Volume with Systemic Lupus Erythematosus Disease Activity: A Meta-analysis

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