Neutrophil-to-lymphocyte ratio may be associated with the outcome in patients with prostate cancer

Abstract

PurposeEvidences have shown that neutrophil-to-lymphocyte ratio (NLR) has a prognostic value in patients with cancer. We wanted to test the prognostic significance of NLR in prostatic cancer of patients who are candidate to radical prostatectomy.MethodsWe have considered 731 patients. Complete demographic data including age, tumor stage, Gleason score, complete blood count and serum biochemical profile were collected. Pre-treatment percentage of neutrophils and NLR were considered, and correlated with patients data and recurrence free survival.Results389 patients were evaluated, mean age 65 years, mean follow-up 51.5 months, mean recurrence free survival 51.3 months. Total neutrophil count does not correlate with biochemical recurrence and disease free survival. Patients with a value higher of 60% of neutrophils are more likely to have a recurrence. Patients with a total lymphocyte count <1,500 have a higher rate of relapse. NLR was not correlated with baseline total PSA, with Gleason score and with pathological stage; patients with a NLR >3 has a higher incidence of recurrence. In multivariate analysis including age, total PSA and NLR, NLR is the most important factor able to predict recurrence. There are some limitations to this study; first, this is a retrospective study, and the total number of patients analyzed is relatively small.ConclusionsOur study suggests that pre-treatment NLR may be associated with disease free survival in patients with prostate cancer, and could be introduced in clinical practice. NLR has the advantage of low economic cost and wide availability.Electronic supplementary materialThe online version of this article (doi:10.1186/s40064-015-1036-1) contains supplementary material, which is available to authorized users.

Prognostic impact of preoperative neutrophil-to-lymphocyte ratio after radical prostatectomy in localized prostate cancer

“…In addition, there were only a few studies that investigated the importance of preoperative NLR in prediction of BCR after RP in localized prostate cancer. 15,16 Minardi et al 15 tested the prognostic significance of NLR in the prostate cancer of patients who were candidates for a RP. In that study, they reported that patients with a NLR of 43 had a higher incidence of recurrence.…”

“…8,14 In addition, there were only a few studies that investigated the importance of preoperative NLR in prediction of biochemical recurrence (BCR) after radical prostatectomy (RP) in localized prostate cancer. 15,16 However, the prognostic significance of NLR in terms of survival in patients who have undergone RP for prostate cancer has never been previously evaluated.…”

Role of systemic inflammatory response markers in urological malignancy

“…A summary of 15 recent studies investigating the prognostic role of NLR in PC is shown in Table . Six studies investigated the prognostic value of NLR in patients who underwent radical prostatectomy for PC; five studies evaluated the preoperative value, and the remaining studies evaluated postoperative values.…”

“…A summary of 15 recent studies investigating the prognostic role of NLR in PC is shown in Table 12. 76,88,[129][130][131][132][133][134][135][136][137][138][139][140][141] Six studies investigated the prognostic value of NLR in patients who underwent radical prostatectomy for PC; five studies evaluated the preoperative value, and the remaining studies evaluated postoperative values. The outcomes of those studies included survival (BCRFS, CSS and OS), as well as pathological results.…”

The prognostic significance of postoperative neutrophil-to-lymphocyte ratio after radical prostatectomy for localized prostate cancer

“…A few studies reported that an elevated NLR has prognostic value after radical prostatectomy (RP) for localized PC [16–18]. However, most of these focused on the prognostic value of NLR in the preoperative setting; no study has assessed the association between postoperative NLR and prognosis after RP for PC.…”