Neutrophil-to-lymphocyte ratio is superior as a prognostic predictor in radiosurgically treated non-small cell lung cancer brain metastases patients under immunotherapy or targeted therapy

Cho, A.; Kranawetter, Beate; Untersteiner, Helena; Khalaveh, Farjad; Dorfer, Christian; Rössler, Karl; Zöchbauer‐Müller, Sabine; Gatterbauer, Brigitte; Hochmair, Maximilian; Frischer, Josa M.

doi:10.1016/j.bas.2021.100693

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“…Eleven studies (23,24,(29)(30)(31)(32)(33)(34)(35)(36)(37) reported the association of NLR and OS in lung cancer patients with BM. The random effects model was applied because the test for heterogeneity showed signi cant heterogeneity among the included studies (P = 0.016, I 2 = 54.0%).…”

Section: Results Of Meta-analysismentioning

confidence: 99%

Prognostic value of pre-treatment neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with brain metastasis from lung cancer: A systematic review and meta-analysis.

Shao

Zhang

Cao

et al. 2022

Preprint

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Background and objective: In modern clinical medicine, the most prevalent category of cancer is lung cancer, and the brain is a routine organ of metastasis for lung cancer. Recently, researchers have evaluated hematologic indicators such as neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) and confirmed that they are valid indices for predicting outcome of lung cancer patients. However, the prognostic significance for lung cancer patients who have progressed to brain metastasis has not been clarified. In our study, a meta-analysis which focus on the association of pre-treatment NLR, PLR and overall survival (OS) in lung cancer patients with brain metastasis was performed and reported. Methods PubMed, Embase and CNKI databases were the scope of our search, and the search methodology was derived from PRISMA. Meta-analyses of OS were performed using random effects models due to significant heterogeneity. This study has been registered on PROSPERO (CRD42022329590). Results We finally included 11 articles to evaluate NLR and PLR in 1977 eligible patients. The NLR group consisted of 11 studies whose meta-analysis showed that OS was significantly shorter in high-NLR patients than low-NLR patients (pooled HR = 1.84 (95% CI: 1.47–2.31)). Five studies were included in the PLR group, and the result suggested that OS was significantly shorter in high-PLR patients than low-PLR patients (pooled HR = 1.53 (95% CI: 1.07–2.20)). Conclusions Meta-analysis showed that association of pre-treatment NLR, PLR and OS are statistically significant. Pre-treatment lower NLR and PLR predict better OS.

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