Neutrophil-to-lymphocyte ratio as an adjunct to CA-125 for the diagnosis of endometriosis

Cho, SiHyun; Cho, Hanbyoul; Nam, Anna S.; Kim, Hye Yeon; Choi, Young Sik; Park, Ki Hyun; Cho, Dong Je; Lee, Byung Seok

doi:10.1016/j.fertnstert.2008.03.061

Cited by 79 publications

(113 citation statements)

References 25 publications

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“…In this context, NLR and PLR could be regarded as simple, inexpensive, and effective inflammation markers that have been linked with several inflammatory and neoplastic diseases [8]. Recent studies have shown that NLR and PLR values are strongly associated with the diagnosis and prognosis of ulcerative colitis, tubo-ovarian abscesses, familial Mediterranean fever, brucella arthritis, and colorectal cancer [8,[14][15][16][17][18]. Although PLR changes in HEG patients have not been studied previously, two recent studies demonstrated that NLR levels are increased and correlated in patients with HEG [6,19].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the hematologic system as a marker of subclinical inflammation in hyperemesis gravidarum: a case control study

et al. 2017

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Objectives: Current evidence suggests that subclinical inflammation plays a significant role in the development of hyperemesis gravidarum (HEG). Simple hematological markers, such as mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR), have been shown to reflect inflammatory burden and disease activity in several disorders. This study aimed to determine the diagnostic value of these hematological parameters for HEG. Material and methods:A total of 54 HEG patients and 58 age-and gestational-age-matched control subjects were studied. NLR, MPV, PLR, platelet distribution width (PDW), and red cell distribution width (RDW) values in all patients were calculated and recorded from complete blood cell counts.Results: For HEG patients, the median NLR was 3.2 (1.6-7.1), and the median PLR was 143.7 (78.1-334.6); for control subjects, the values were 2.1 (1.0-4.7) and 93.1 (47.3-194.7), respectively. Although both the NLR and PLR of HEG patients were found to be significantly higher than in the controls, no significant difference was found between the study groups in terms of MPV, RDW, or PDW. Correlation analysis revealed a significant correlation between NLR and CRP (r = 0.872, p < 0.001). Conclusions:Our results show that peripheral blood NLR and PLR values can reflect inflammatory burden in HEG patients and can be used as markers for HEG.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the hematologic system as a marker of subclinical inflammation in hyperemesis gravidarum: a case control study

et al. 2017

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“…Serum IL levels, urocortin, or vitamin D binding globulin would bring high costs and have no chance for use in the hospital setting (1,8,9). Cho et al (22) showed that NLR alone or in combination with Ca-125 would offer an inexpensive and practical method for the diagnosis of endometriosis. This analysis is performed in an ordinary haematology analyser found in every hospital.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of mean platelet volume, neutrophil/lymphocyte ratio and platelet/lymphocyte ratio in advanced stage endometriosis with endometrioma

Yavuzcan¹,

Çağlar²,

Üstün³

et al. 2013

J Turkish German Gynecol Assoc

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Objective:We compared the preoperative values of mean platelet volume (MPV) and peripheral systemic inflammatory response (SIR) markers (neutrophil/lymphocyte ratio and platelet/lymphocyte ratio) between patients with advanced-stage (stage 3/4) endometriosis having endometrioma (OMA) and patients with a non-neoplastic adnexal mass other than endometrioma (non-OMA). Material and Methods:Patients who underwent operations with the pre-diagnosis of infertility or adnexal mass and who underwent laparoscopic tubal ligation were included. Results:Haemoglobin levels, leucocyte count, platelet count, neutrophil count and lymphocyte count were not significantly different between patients with advanced stage endometriosis having OMA, patients with non-OMA and patients in the control group (p=0.970, p=0.902, p=0.373, p=0.501 and p=0.463, respectively). Patients with stage 3/4 endometriosis having OMA, patients with non-OMA and control patients were also not significantly different in terms of MPV (p=0.836), neutrophil/lymphocyte ratio (NLR) (p=0.555) and platelet/lymphocyte ratio (PLR) (p=0.358). Preoperative cancer antigen 125 (Ca-125) levels were significantly higher in patients with OMA (p=0.006). Mean size of the OMAs was significantly lower than nonOMAs (p=0.000). Conclusion:It is very important to determine advanced stage endometriosis and OMAs during preoperative evaluation in order to inform patients and plan an appropriate surgical approach. We demonstrate that MPV, NLR and PLR values are not useful for this purpose in patients with advanced stage endometriosis that are proven to develop severe inflammation at either the cellular or molecular level. (J Turkish-German Gynecol Assoc 2013; 14: 210-5) Key words: Endometriosis, mean platelet volume, neutrophil/lymphocyte ratio, platelet/lymphocyte ratio Received: 21 July, 2013 Accepted: 07 August, 2013 Amaç: Biz endometrioma bulunan ileri evre endometriozise sahip hastalar (evre 3/4) ve endometrioma dışı non-neoplastik adneksiyel kitle bulunan hastalar arasında preoperatif ortalama trombosit hacmi (MPV) ve periferik sistemik inflamatuvar yanıt (SIR) belirteçlerinin (nötrofil / lenfosit oranı ve lenfosit/trombosit oranı) değerlerini karşı-laştırdık. Gereç ve

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“…Studies were published showing that the neutrophil lymphocyte ratio (NLR) increased, one of the systemic inflammation markers in endometriosis. In 2008 Cho S.et al made a study on 231 patients with endometriosis and 384 healthy patients in the control group and NLR ratio was found significantly higher in the group with endometriosis [13]. In 2013 in the study made by YANG et al NLR was found significantly higher in the group with endometriosis compared to the control group [14].…”

Section: Discussionmentioning

confidence: 99%

Role of Neutrophil Lymphocyte Ratio at Preoperative Adenomysosis Diagnosis

Kececioglu¹,

Tokmak²,

Sarıkaya³

et al. 2016

Med-Science

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Neutrophil-to-lymphocyte ratio as an adjunct to CA-125 for the diagnosis of endometriosis

Cited by 79 publications

References 25 publications

Evaluation of the hematologic system as a marker of subclinical inflammation in hyperemesis gravidarum: a case control study

Evaluation of the hematologic system as a marker of subclinical inflammation in hyperemesis gravidarum: a case control study

Evaluation of mean platelet volume, neutrophil/lymphocyte ratio and platelet/lymphocyte ratio in advanced stage endometriosis with endometrioma

Role of Neutrophil Lymphocyte Ratio at Preoperative Adenomysosis Diagnosis

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