Neutrophil-to-lymphocyte ratio as a prognostic marker in critically-ill septic patients

Correlation between neutrophil-to-lymphocyte ratio and severity scores in septic patients upon hospital admission. A series of 50 patients

“…Our results seem to be partially in accordance to those by Hwang et al [5]. The serum CRP values in our series of patients failed to significantly correlate to the sepsis severity scores on admission.…”

“…In a large study by Hwang et. al published in 2017, including 1395 patients with severe sepsis and septic shock, NLR measured at Emergency Department (ED) admission was independently associated with 28-day mortality [5].…”

Transient and Persistent AKI and Outcomes in Patients Undergoing Major Abdominal Surgery

“…In a previous study, we reported an association of postoperative NLP ratio and development of postoperative AKI [21]. NLP ratio is a surrogate marker of inflammation which plays an important role in the systemic consequences of AKI [46]. Nonetheless, we did not find a correlation between the NLP ratio and persistent postoperative AKI.…”

The utility of peripheral blood leucocyte ratios as biomarkers in infectious diseases: A systematic review and meta-analysis

“…The NLR was examined retrospectively in 1395 patients with severe sepsis (46%) or septic shock (54%), defined using 2001 criteria. 13,14 Patients were excluded if they had terminal malignancy, a previous "do not resuscitate" order or declined invasive procedures. The most common sites of infection were lung, intraabdominal and urinary tract.…”

“…9 Whilst this paradigm is consistent with some of the observations that have been reported, an apparent paradox exists where some studies report the converse. 13,16 Neutrophil depletion is one possible contributing factor but this warrants further investigation and highlights the importance of high-throughput clinical phenotyping. 1 Sepsis syndrome includes a wide range of infectious aetiologies and heterogeneous host responses.…”