Neutrophil-to-lymphocyte ratio as a prognostic marker in acute respiratory distress syndrome patients: a retrospective study

Wang, Ying; Ju, Mohan; Chen, Cuicui; Yang, Dong; Hou, Dongni; Tang, Xinjun; Zhu, Xiaodan; Zhang, Donghui; Wang, Lilin; Ji, Shimeng; Jiang, Jinjun; Song, Yuanlin

doi:10.21037/jtd.2017.12.131

Cited by 77 publications

(66 citation statements)

References 26 publications

(41 reference statements)

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“…Data presented as mean (range), mean ±standard deviation, or n(%), BMI, body mass index distress syndrome, community-acquired pneumonia and sarcoidosis and tuberculosis. [13][14][15][16][17] In this study, NLR has been found to be statistically significantly higher in silicosis patients with profusion categories 2 and 3 when compared to the control group. The NLR in patients with profusion category 1 was also higher than controls; however, the difference was not significant.…”

Section: Discussionsupporting

confidence: 50%

“…NLR has been shown to be an independent prognostic factor in several types of tumours, including colorectal, lung, breast, pancreatic, gastric and ovarian cancer . Studies have also shown a correlation between the NLR and the prognosis and severity of the clinical course in pulmonary diseases such as chronic obstructive pulmonary disease, acute respiratory distress syndrome, community‐acquired pneumonia and sarcoidosis and tuberculosis . In this study, NLR has been found to be statistically significantly higher in silicosis patients with profusion categories 2 and 3 when compared to the control group.…”

Section: Discussionsupporting

confidence: 49%

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Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio as haematological indices of inflammatory response in ceramic workers’ silicosis

Karataş¹,

Gündüzöz

Öziş³

et al. 2019

Clinical Respiratory J

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Introduction Occupational exposure to crystalline silica over time may result in silicosis: a fatal, irreversible occupational disease leading to lung function impairment. A complex inflammatory process, excessive accumulation of mesenchymal cells and collagen production are the primary mechanisms underlying silicosis. Neutrophil to lymphocyte ratio (NLR) and the platelet to lymphocyte ratio (PLR) have emerged as representative indices of systemic inflammation. Objectives The purpose of the present study was to investigate the relationship between NLR, PLR and silicosis. Methods We retrospectively analysed the demographic and laboratory data of ceramic workers who were referred to our Hospital between 2010 and 2018. Five hundred and seventy‐three patients with silicosis and 222 ceramic workers without silicosis (controls) were included in the study. Results The radiographic ILO classification of silicosis patients was as follows: category 1 (71.5%), category 2 (19.2%), category 3 (7.5%). NLR and PLR in categories 2 and 3 were significantly higher when compared with the control group (P < .005). FEV1, FEV1%, FVC, FVC % and PEF were significantly lower in all silicosis patients and also in patients with subcategories (all P < .005). NLR showed a poor positive correlation with CRP (r = 0.095, P < .05) and ESR (r = 0.207, P = .000) while PLR only with ESR (r = 0.317, P = .000) in patients with silicosis. NLR and PLR showed negative correlations with FEV1, FVC and PEF (all P < .005). Conclusion We conclude that NLR and PLR have significant but poor correlations with pulmonary functions and severity of silicosis, especially in late radiographic profusion categories.

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Section: Discussionsupporting

confidence: 50%

Section: Discussionsupporting

confidence: 49%

Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio as haematological indices of inflammatory response in ceramic workers’ silicosis

Karataş¹,

Gündüzöz

Öziş³

et al. 2019

Clinical Respiratory J

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“…The NLR is calculated as the absolute neutrophil count divided by the absolute lymphocyte count, while the PLR is calculated by platelet count divided by absolute lymphocyte count. In the recent years, NLR and PLR have been validated as prognostic markers in various disorders such as cardiac conditions, solid tumors, sepsis, pneumonia, and acute respiratory distress syndrome (ARDS) [8][9][10][11][12][13]. Few studies have evaluated the role of NLR and PLR in patients with severe and non-severe COVID-19.…”

Section: Introductionmentioning

confidence: 99%

Use of Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in COVID-19

2020

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Background: As the pandemic of coronavirus disease 2019 (COV-ID-19) continues, prognostic markers are now being identified. The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are easily accessible values that have been known to correlate with inflammation and prognosis in several conditions. We used the available data to identify the association of NLR and PLR with the severity of COVID-19. Methods: A literature search using EMBASE, MEDLINE, and Google Scholar for studies reporting the use of NLR and PLR in COVID-19 published until April 28, 2020, was performed. Random effects meta-analysis was done to estimate standard mean difference (SMD) of NLR and PLR values with 95% confidence interval (CI) between severe and non-severe COVID-19 cases. Results: A total of 20 studies with 3,508 patients were included. Nineteen studies reported NLR values, while five studies reported PLR values between severe and non-severe COVID-19 patients. Higher levels of NLR (SMD: 2.80, 95% CI: 2.12-3.48, P < 0.00001) and PLR (SMD: 1.82, 95% CI: 1.03-2.61, P < 0.00001)) were seen in patients with severe disease compared to non-severe disease. Conclusions: NLR and PLR can be used as independent prognostic markers of disease severity in COVID-19.

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“…Growing evidence suggests that NLR and other haematological markers of the systemic inflammatory response can reliably predict inflammatory response and survival in patients with malignancy. 9 – 14 Many groups have investigated the prognostic value of the NLR in a variety of inflammatory diseases at differing stages of disease. 16 , 17 …”

Section: Discussionmentioning

confidence: 99%

“… 7 The NLR is calculated by dividing the neutrophil count by the lymphocyte count. 8 NLR is already used as an easily accessible inflammatory marker in adults with acute respiratory distress syndrome, 9 spontaneous bacterial peritonitis, 10 ischaemic heart disease, metabolic disease, cancer and other medical conditions. 11 In children, NLR can differentiate between viral and bacterial pneumonia, 12 , 13 and it can be a useful diagnostic marker of acute appendicitis and acute infection.…”

Section: Introductionmentioning

confidence: 99%

<p>Prognostic Value of Neutrophil-to-Lymphocyte Ratio in Predicting Death Risk in Patients with Severe Hand, Foot and Mouth Disease</p>

Li¹,

Wang²,

Wang³

et al. 2020

TCRM

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Introduction Severe hand, foot, and mouth disease (HFMD) may lead to serious complications, which cause child mortality during outbreaks. The aim of this study was to determine whether neutrophil-to-lymphocyte ratio (NLR) can predict death risk in severe HFMD. Methods Medical records for 664 severe HFMD patients were retrospectively examined, and NLR was calculated from blood counts. Youden’s index was calculated to determine the optimal NLR cutoff. Uni- and multivariate logistic regression were used to determine death risk factors associated with severe HFMD. Results An NLR cutoff value of 2.01 and 2.50 respectively predicted mortality among all 664 severe HFMD and 137 critical HFMD. Among all 664 patients, the multivariate model identified the following as independently associated with death risk: high fever (OR 3.342, 95% CI 1.736–6.432), EV71 infection (OR 3.200, 95% CI 1.529–6.698), fasting glucose (OR 37.343, 95% CI 18.616–74.909), and NLR (>2.01) (OR 2.142, 95% CI 1.125–4.079). Among 137 critical HFMD, EV71 infection (OR 3.441, 95% CI 1.132–10.462), fasting glucose (OR 14.173, 95% CI 4.920–40.827), and NLR (>2.50) (OR 4.166, 95% CI 1.570–11.051) were associated with death risk. Conclusion In conclusion, NLR (>2.01) in severe HFMD and NLR (>2.50) in critical HFMD patients may be associated with increased death risk.

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Neutrophil-to-lymphocyte ratio as a prognostic marker in acute respiratory distress syndrome patients: a retrospective study

Abstract: The NLR is potentially a predictive prognostic biomarker in ARDS patients.

Cited by 77 publications

References 26 publications

Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio as haematological indices of inflammatory response in ceramic workers’ silicosis

Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio as haematological indices of inflammatory response in ceramic workers’ silicosis

Use of Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in COVID-19

<p>Prognostic Value of Neutrophil-to-Lymphocyte Ratio in Predicting Death Risk in Patients with Severe Hand, Foot and Mouth Disease</p>

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