Neutrophil-to-lymphocyte ratio as a predictor of inflammatory response in patients with acute kidney injury after transcatheter aortic valve implantation

Olasińska-Wiśniewska, Anna; Urbanowicz, Tomasz; Grodecki, Kajetan; Perek, Bartłomiej; Grygier, Marek; Michalak, Michał; Misterski, Marcin; Puslecki, Mateusz; Rodzki, Michał; Poniedziałek, Barbara; Lesiak, Maciej; Jemielity, Marek

doi:10.17219/acem/149229

Cited by 4 publications

(4 citation statements)

References 34 publications

(48 reference statements)

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“…[33][34][35] Simple parameters from whole blood count, including NLR, MLR and SIRI, were postulated to be related to atherosclerosis progression. [36][37][38][39][40][41][42] However, in our analysis, none of these indices were related to carotid artery occlusion, although we previously presented the prognostic value of MLR for collateral carotid artery involvement. 32 The significant difference between LUCs and lymphocyte, monocyte and neutrophil counts is based on the characteristics of the cells; LUC counts take into account activated cells, while other cell counts measure the concentration of the cells.…”

Section: Discussioncontrasting

confidence: 53%

Large unstained cell (LUC) count as a predictor of carotid artery occlusion

et al. 2023

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Background. Carotid artery stenosis is often considered a stable clinical condition, and the underlying atherosclerosis is thought to have an inflammatory background.Objectives. The aim of the study was to assess the value of different parameters obtained from whole blood counts for the prediction of advanced carotid artery atherosclerosis, including vessel occlusion, irrespective of symptom occurrence. Materials and methods.The study group comprised 290 patients (84 (29%) females and 206 (71%) males) with a mean age of 68 ±8 years, who were admitted to the Vascular Surgery Department due to significant carotid artery disease. Patients were retrospectively divided into 2 subgroups regarding the presence or absence of artery occlusion. The demographic, clinical and laboratory preoperative data were compared between both groups.Results. We found significant differences in preoperative large unstained cell (LUC) counts between patients with and without carotid artery occlusion (p = 0.003), when analyzed with the Mann-Whitney test for independent samples. The receiver operating characteristic (ROC) curve showed that LUC count has prognostic properties for carotid artery occlusion, with an area under the curve (AUC) of 0.637 (p = 0.033), yielding a 69.70% sensitivity and a 51.75% specificity. Conclusions.Large unstained cells represent an acute inflammatory state related to artery occlusion. An LUC count below the cutoff value of 0. 16×10 9 /L may be a predictor of carotid artery occlusion. Therefore, carotid artery occlusion should not be regarded as a chronic state, but as a clinical challenge being promoted by active inflammatory processes.

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Section: Discussioncontrasting

confidence: 53%

Large unstained cell (LUC) count as a predictor of carotid artery occlusion

et al. 2023

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“…Olasinska-Wisniewska et al 19 also discovered that NLR increased significantly after TAVI in both the lowest and highest quartiles, with the increase being significantly greater in patients who developed AKI (median NLR of 8.3 vs. 4.9, p= 0.005). Another study by Olasinska-Wisniewska et al 20 revealed that NLR was decreased significantly after TAVI. We also found that the post-procedural NLR≥ 5.7 was an independent risk factor for AKI.…”

Section: Discussionmentioning

confidence: 93%

“…[15][16][17] Following TAVI, the NLR has been linked to the development of AKI. [18][19][20] The average platelet volume (MPV) is a computerized measurement of platelet size. As a result of increased platelet size, an increased MPV indicates larger, more reactive platelets.…”

Section: Introductionmentioning

confidence: 99%

The predictive value of neutrophil to lymphocyte ratio and mean platelet volume on acute kidney injury after TAVI

Turen¹,

Yılmaz

2022

SYBD

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Objective: Transcatheter aortic valve implantation (TAVI) is an effective treatment for severe aortic stenosis. Acute kidney injury (AKI) is a common complication after TAVI. The development of AKI after TAVI has been linked to the thromboinflammatory response as evaluated by the neutrophil-to-lymphocyte ratio (NLR) and mean platelet volume (MPV). We sought to determine the predictive value of NLR and MPV on AKI after TAVI in this study. Method: This is a single-center retrospective study. Baseline, peri-procedural, and post-procedural demographic, laboratory, and clinical characteristics were assessed for AKI. The optimal NLR and MPV cut-off values for predicting AKI were determined using receiver operating characteristic (ROC) curve analysis. Results: A total of 184 consecutive patients (age 79.4 ± 7.8 years, 61.4% female) who underwent TAVI were included in this study. The optimal cut-off points for the NLR and MPV were 5.70 (AUC: 0.790; 95% CI: 0.711-0.869, p<0.001 and sensitivity= 80.0%, specificity= 65.2%) and 9.15 fL (AUC:0.713; 95% CI: 0.629-0.997, p<0.001 and sensitivity=70.7%, specificity=63.6%), respectively. AKI occurred in 41 (22.3%) patients included in the study and 6 (3.3%) required dialysis. Baseline GFR (OR: 0.98; 95% CI: 0.94-0.99, p = 0.001), post-procedural WBC count (OR: 1.17; 95% CI: 1.03-1.33, p= 0.02), post-procedural NLR≥ 5.7 (OR: 5.16; 95% CI: 1.84-14.48, p= 0.002), and post-procedural MPV ≥ 9.15 fL (OR: 3.70; 95% CI: 1.54–8.91, p= 0.004) were found to be the independent predictors of AKI after TAVI in multivariable analysis. Conclusion: Post-procedural NLR and MPV were found to be independent predictors of AKI after TAVI.

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“…However, using such markers in clinical practice is not possible, as a profound analysis of inflammatory phenomena is challenging and not costeffective. 18,19 Hence, simpler methods, such as whole blood analysis, were introduced and described as sufficient for demonstrating complex changes in the inflammatory response to cardiovascular disorders and predicting adverse outcomes or diminished survival. The results of whole blood analysis are readily available, and the method is repeatable, which gives it an advantage over other methods.…”

Section: Introductionmentioning

confidence: 99%

The beneficial role of simple inflammatory blood indices in pediatric cardiology

Olasińska-Wiśniewska¹,

Urbanowicz²,

Gładki³

et al. 2023

Adv Clin Exp Med

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Neutrophil-to-lymphocyte ratio as a predictor of inflammatory response in patients with acute kidney injury after transcatheter aortic valve implantation

Abstract: Olasińska-Wiśniewska A, Urbanowicz T, Grodecki K, et al. Neutrophil-to-lymphocyte ratio as a predictor of inflammatory response in patients with acute kidney injury after transcatheter aortic valve implantation [published online as ahead of print on May 12, 2022].

Cited by 4 publications

References 34 publications

Large unstained cell (LUC) count as a predictor of carotid artery occlusion

Large unstained cell (LUC) count as a predictor of carotid artery occlusion

The predictive value of neutrophil to lymphocyte ratio and mean platelet volume on acute kidney injury after TAVI

The beneficial role of simple inflammatory blood indices in pediatric cardiology

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