Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in chronic periodontitis before and after nonsurgical therapy

Acharya, Anirudh B.; Shetty, Indrajith Padukone; Jain, Shrinidhi; Padakannaya, Ibbani Prateek; Acharya, Swetha; Shettar, Leena; Thakur, Srinath

doi:10.4103/jisp.jisp_622_18

Cited by 22 publications

(10 citation statements)

References 44 publications

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“…Concerning the role of platelets in the pathogenesis of periodontitis, these specialized inflammatory cells are now widely acknowledged to have a role in several elements of inflammatory immune reactions, including leukocytic and endothelial interactions and the release of inflammatory mediators (Stokes & Granger, 2012). While a few studies have reported a significant increase in platelet count in periodontitis (reactive thrombocytosis; Kumar et al, 2014; Romandini et al, 2018), our study, like others previou studies (Acharya et al, 2019; Lu et al, 2021), found no comparable difference in platelet level between patients with severe periodontitis and periodontally healthy individuals, implying that platelet activation and function, rather than absolute platelet counts, are more important in the pathogenesis of periodontitis (Papapanagiotou et al, 2009). Because of such variability in the results, the relevance of individual leukocyte counts in predicting severe periodontitis is questioned.…”

Section: Discussionsupporting

confidence: 84%

Systemic immune‐inflammation index in patients with generalized stage III grade C periodontitis

et al. 2022

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ObjectivesSystemic immune‐inflammation index (SII) is a novel, inflammatory biomarker whose role in predicting several chronic systemic diseases has been recently identified. However, its association with generalized stage III grade C periodontitis in young adults remains unknown.Material and MethodsThe study is a multicentered, double‐blind, hospital‐based case–control clinical study. Periodontal examination comprised of recording plaque index, sites with bleeding on probing, pocket depth and clinical attachment loss for patients with generalized stage III grade C periodontitis and periodontally healthy group. Complete blood counts were obtained and used for calculating SII, neutrophil‐lymphocyte ratio (NLR) and platelet‐lymphocyte ratio. Collected data were then subjected to statistical analyses.ResultsSII was significantly higher in patients with generalized stage III grade C periodontitis compared to periodontally healthy individuals (723.87 vs. 537.74 × 109/L, p < 0.0001). SII is associated with severe periodontitis in young adults (odds ratio [OR]:11.86, 95% CI 9.61–20.76, p < 0.0001) after adjusting for factors found significant in univariate analysis. Receiver operative curve analysis demonstrated a fair predictive validity of SII in detecting generalized stage III grade C periodontitis in young adults (AUC: 0.766, 95%CI 0.731–0.799, p < 0.0001, sensitivity 81.27%, specificity 76.50% and diagnostic accuracy 78.89%). SII did not exhibit superior predictive validity when compared with NLR in the context of generalized stage III grade C periodontitis (AUC for SII: 0.766, 95%CI 0.731–0.799, AUC for NLR: 0.788, 95% CI 0.754–0.819; p = 0.28).ConclusionSII is associated with generalized stage III grade C periodontitis in young adults.

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Section: Discussionsupporting

confidence: 84%

Systemic immune‐inflammation index in patients with generalized stage III grade C periodontitis

et al. 2022

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“…Leukocytes and PLT rise in response to periodontal pathogens and decrease after periodontal treatment. 25,26 In our study; WBC and PLT values were statistically higher in the case group with worse periodontal status. This result is compatible with the literature.…”

Section: Discussionsupporting

confidence: 45%

Is Periodontal Disease a Risk Factor for Premature Birth and Low Birth Weight

CERAN DEVECİ,

ÇALIŞIR,

DEVECİ

et al. 2023

neudentj

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Aim: Premature birth or low birth weight has an important place in neonatal mortality and morbidity. Today, there are still cases whose etiology has not been fully elucidated. The aim of this study is to evaluate the effect of periodontal diseases on adverse pregnancy outcomes by using the current classification system accepted at the 2017 World Workshop. Materials and Methods: This study was carried out on 172 women who were followed up and delivered in the department of obstetrics and gynecology of our university’s medical faculty hospital. Demographic characteristics of all individuals were recorded and laboratory values were examined. While those with a gestational age <37 weeks and/or baby birth weight < 2500 g were constituted to the case group (n=85), those with a gestational age ≥ 37 weeks and/or baby birth weight ≥ 2500 g constituted the control group (n=87). Clinical periodontal and radiographic evaluations including plaque index (PI), gingival index (GI), bleeding on probing (BOP %), probing pocket depth (PPD) and clinical attachment level (CAL) values were performed for all individuals, and the diagnoses were made by the applied classification system. Analyzes were performed between the two groups to examine the relationship between periodontal disease and adverse pregnancy. Results: PI, GI, BOP %, and PPD values in the case group were significantly higher compared to the control group (p<0.001). Although the CAL value was higher in the case group, the difference was not significant (p=0.058). WBC (p=0.020) and PLT (p<0.001) values were significantly higher in the case group. Conclusion: According to the results of this study, periodontal diseases are associated with adverse pregnancy outcomes independent of other risk factors. Women should pay attention to their oral hygiene and dental examinations before and during pregnancy.

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“…WBCs, composed of neutrophils, lymphocytes, and other intermediate cells, are critical defense system components. 49 Recently, NLR has been proposed as a strong biomarker for the prognosis of several inflammatory diseases, including periodontitis 50,51 and diabetes, 52 which is more stable and effective than WBC, neutrophil, and lymphocyte counts alone. and periodontitis also reported that the likelihood of a significant HbA1c decrease after NSPT was higher for patients with severe periodontitis and high baseline WBC counts than for those with lower baseline levels.…”

Section: Discussionmentioning

confidence: 99%

“…WBCs, composed of neutrophils, lymphocytes, and other intermediate cells, are critical defense system components 49 . Recently, NLR has been proposed as a strong biomarker for the prognosis of several inflammatory diseases, including periodontitis 50,51 and diabetes, 52 which is more stable and effective than WBC, neutrophil, and lymphocyte counts alone. Torrungruang et al.…”

Section: Discussionmentioning

confidence: 99%

Effects of amoxicillin and metronidazole as an adjunct to scaling and root planing on glycemic control in patients with periodontitis and type 2 diabetes: A short‐term randomized controlled trial

Xu,

Lu,

Huo

et al. 2023

J of Periodontal Research

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ObjectiveTo assess the effects of amoxicillin and metronidazole with scaling and root planing (SRP) on periodontal parameters and glycemic control in patients with severe periodontitis and diabetes mellitus.BackgroundAdjunctive antibiotics use is advantageous for treating periodontitis in patients with severe periodontitis and diabetes. However, the effects of adjunctive antibiotic use on hemoglobin A1c (HbA1c) levels remain unclear.MethodsThis short‐term, randomized controlled trial enrolled patients with severe periodontitis and type 2 diabetes. The patients were randomly allocated to SPR only (i.e., control) or SPR + antibiotics (500 mg of amoxicillin and 200 mg of metronidazole, three times daily for 7 days) groups. Periodontal and hematological parameters were assessed at baseline and 3 months after treatment. Inter‐ and intra‐group analyses were performed using Student's t‐tests, Mann–Whitney U tests, and the binary logistic regression models. p‐values of <.05 were considered statistically significant.ResultsThis study enrolled 49 patients, with 23 and 26 patients in the SRP‐only and SRP + antibiotics groups, respectively. The periodontal parameters improved significantly and similarly in both groups after treatment (p < .05). The SRP + antibiotics group had more sites of improvement than the SRP‐only group when the initial probing depth was >6 mm. (698 [78.96%] vs. 545 [73.35%], p = .008). The HbA1c levels decreased in the SRP‐only and SRP + antibiotics groups after treatment (0.39% and 0.53%, respectively). The multivariable binary logistic regression model demonstrated that antibiotics administration and a high baseline HbA1c level were associated with a greater reduction in the HbA1c level (odds ratio = 4.551, 95% confidence interval: 1.012–20.463; odds ratio = 7.162, 95% confidence interval: 1.359–37.753, respectively).ConclusionsSRP and SRP plus systemic antibiotics were beneficial for glycemic control. Adjunctive antibiotic use slightly improved the outcome for patients with severe periodontitis and poorly controlled diabetes.

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Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in chronic periodontitis before and after nonsurgical therapy

Cited by 22 publications

References 44 publications

Systemic immune‐inflammation index in patients with generalized stage III grade C periodontitis

Systemic immune‐inflammation index in patients with generalized stage III grade C periodontitis

Is Periodontal Disease a Risk Factor for Premature Birth and Low Birth Weight

Effects of amoxicillin and metronidazole as an adjunct to scaling and root planing on glycemic control in patients with periodontitis and type 2 diabetes: A short‐term randomized controlled trial

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