Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio: Novel Markers for Diagnosis and Prognosis in Patients with Idiopathic Sudden Sensorineural Hearing Loss

Abstract

Background. We aim to provide useful evidence about the association of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) with idiopathic sudden sensorineural hearing loss (ISSNHL) and its possibility of emerging as a cheap, reliable, and independent prognostic marker of ISSNHL. Methods. 348 patients diagnosed with ISSNHL were included in our retrospective data analysis. Blood samples and the hearing assessments of the patients were carried out. Then, the patients were divided into 2 groups as “recovered” and “unrecovered” according to their response to the treatment. Results. Both mean NLR and PLR values of the ISSNHL patients were significantly higher than the control group (both P < 0.001). The NLR value was 5.98 ± 4.22 in the unrecovered group and 3.50 ± 3.38 in the recovered group (P < 0.001). After adjustment in a binary logistic regression model, only NLR value was associated with the recovery of ISSNHL (P = 0.001). Discussion. We demonstrated for the first time that NLR and PLR values were significantly high in ISSNHL patients. Also the NLR level might be taken into account as a novel potential marker to predict the patients' prognosis in terms of recovery.

Sudden sensorineural hearing loss: is there a relationship between routine haematological parameters and audiogram shapes?

“…Mirvakili et al (2016) in a prospective case-control study showed no association between PC, MPV and PDW and occurrence of SSNHL; only PDW resulted correlated with the severity of hearing loss (p ¼ 0.043). On the contrary, Sagit et al (2013) and Seo et al (2014) analysing, respectively, haematological data of 31 and 348 SSNHL patients evidenced a significant difference in PC values between subjects with and without SSNHL. Furthermore, Yasan et al (2013), Wittig et al (2014), Quaranta et al (2015), Kum et al (2015) did not recognise PC as prognostic factor for hearing recovery (p40.05).…”

“…In particular, Seo et al (2014) and Kum et al (2015) showed lower values of lymphocyte count in patients with less than 15 dB HL of hearing gain with respect to the initial hearing loss. Masuda et al (2012), _ Ikinciogullar{ et al (2014) and Quaranta et al (2015) instead did not observe any correlation between lymphocyte count and recovery rate.…”

Study the relationship between nasal polyps, platelet count, mean platelet volume, neutrophil/lymphocyte ratio in patients attending otolaryngology OPD in a tertiary care teaching hospital, West Bengal

“…39 Sudden sensorineural hearing loss, Bell's palsy and vestibular neuritis are certain pathological conditions that have been found to be related to NLR and PLR in otolaryngological practice. [40][41][42] Mean platelet volume (MPV) is a blood marker related to function and activation of platelets. 43 A study on patients with stroke reported that NLR increase and CRP (C reactive protein) which is an inflammation marker are significantly correlated.…”

Neutrophil-to-Lymphocyte and Platelet-to- Lymphocyte Ratios in Pediatric Patients with Idiopathic Sudden Hearing Loss

“…Besides, the platelet-to-lymphocyte ratio (PLR) has been to be related to a poor prognosis in patients with peripheral arterial disease [5] . There are studies in the literature that show a relationship between SHL prognosis in adults and the NLR and PLR [6] .…”