Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Patients with Sudden Sensorineural Hearing Loss

Abstract

Objective: Sudden sensorineural hearing loss (SSNHL) is a common acute disease with an incidence of 0.5–2/10,000. This study aimed to determine whether the neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) could be indicators for SSNHL. Methods: A total of 60 confirmed cases of SSNHL and 60 healthy volunteers were included in this study. Peripheral blood NLRs and PLRs were compared between these groups. The SSNHL patients were divided into two groups, according to therapeutic effect: an effective group and an ineffective group. Peripheral blood NLRs and PLRs before and after treatment were compared between these two groups. Results: The average NLRs and PLRs of these patients were both significantly higher than in controls. The average NLRs and PLRs of the ineffective group were both significantly higher than those of the effective group. Conclusion: Peripheral blood NLR and PLR could be used as a convenient, reliable, and cost-effective indicator to predict the prognosis of SSNHL.

Biomarkers Suggesting Favorable Prognostic Outcomes in Sudden Sensorineural Hearing Loss

“…SSNHL can occur at all ages, but it is rare in children. Because NLR and PLR were found to be associated with SSNHL in adults [ 32 , 33 ], these associations were also investigated in children. NLR differed significantly between children with SSNHL and controls and between children with SSNHL who did and did not recover after treatment.…”

Association between routine hematological parameters and sudden sensorineural hearing loss: A meta-analysis

“…From the remaining 44 articles, we excluded one study because it was not published in English, seven articles as they lacked outcomes of interest, five articles that did not give the mean and standard deviation of NLR, PLR, and MPV values, two articles that reported the same population, six letters, and five articles that focused on other topics. Finally, 18 studies ( Ulu et al., 2013 ; K et al., 2016 ; Qiao et al., 2019 ; Karli et al., 2013 ; Ikinciogullari et al., 2014 ; Lee et al., 2017 ; Zheng et al., 2014 ; Yasan et al., 2013 ; Seo et al., 2014 ; Sagit et al., 2013 ; Quaranta et al., 2015 ; Ozler, 2014 ; Nonoyama et al., 2016 ; Mirvakili et al., 2016 ; Kum et al., 2015 ; Kocak et al., 2017 ; Ha et al., 2019 ; Bulğurcu et al., 2017 ) were eligible for meta-analysis. ( Fig.…”

“…Overall, ten articles ( Ulu et al., 2013 ; Qiao et al., 2019 ; Ikinciogullari et al., 2014 ; Lee et al., 2017 ; Seo et al., 2014 ; Ozler, 2014 ; Kum et al., 2015 ; Kocak et al., 2017 ; Ha et al., 2019 ; Bulğurcu et al., 2017 ) evaluated the diagnostic values of NLR in SSNHL in a total of 810 SSNHL patients and 1016 healthy controls. Owing to the extreme heterogeneity (P = 0.006, I2 = 61%)among the included studies, a random-effects model was used to assess the pooled outcome.…”

“…Overall, seven papers ( Qiao et al., 2019 ; Ikinciogullari et al., 2014 ; Lee et al., 2017 ; Seo et al., 2014 ; Kocak et al., 2017 ; Ha et al., 2019 ; Bulğurcu et al., 2017 ) estimated the diagnostic value of PLR in SSNHL in a total of 664 SSNHL patients and 872 healthy individuals. Given the extreme heterogeneity among the studies (P < 0.001, I 2 = 76%), a random-effects model was adopted.…”

“…To date, several studies have revealed a strong link between these hematologic parameters and the diagnosis/prognosis of SSNHL. Some studies reported that higher NLR, PLR, and MPV values may predict poor prognosis of SSNHL ( K et al., 2016 ; Qiao et al., 2019 ; Sun et al., 2017 ), By contrast, other studies have challenged this association ( Karli et al., 2013 ; Ikinciogullari et al., 2014 ; Lee et al., 2017 ). Thus, this meta-analysis was designed to clarify the association of these hematologic biomarkers with the diagnosis and prognosis of SSNHL patients.…”