Neutrophil-to-lymphocyte ratio and mean platelet volume in the diagnosis of bacterial infections in COVID-19 patients. A preliminary analysis from Ecuador

Abstract

Hospitalized COVID-19 patients are at risk of hospital infection. The neutrophil-to-lymphocyte ratio (NLR), lymphocyte-C-reactive protein ratio (LCR) and mean platelet volume (MPV) are established inflammation markers reflecting the systemic inflammatory response. The objective of this study was to evaluate the clinical characteristics of patients with COVID-19 and bacterial co-infections, as well as the correlation with NLR and MPV. Methods: We assessed the role of the NLR and MPV in diagnosing bacterial infections in COVID-19 patients. The Wilcoxon test was used to compare the mean NLR and MPV between the diagnostic evaluation moments, while the Mann-Whitney test was used to compare NLR and MPV by sex and age. Results: The NLR was compared three days before the culture and the day of taking the culture, observing SUMMARY significant differences (p=0.020). MPV three days before the culture and the day of the culture were compared, also observing significant differences (p=0.031). NLR and MPV were compared at the different evaluation times according to sex and age group, observing for the age group significant differences for the NLR three days before the culture (p=0.004). Conclusion: In our study, there were significant differences in NLR and MPV between the three days before culture and the day of culture. It is advisable to continue to enrol more patients in the study so that in the future, we can add results on the diagnostic accuracy of the NLR and MPV in the timely diagnosis of bacterial infection in patients with COVID-19.

Association Between Mean Platelet Volume and Benign Prostatic Hyperplasia: A Population Study from the TCLSIH Cohort Study

“…11 In addition, a case-control study also found that MPV might be a predictor of the development of BPH. 12 Despite the fact that it is a simple and inexpensive biomarker of inflammation and is associated to a number of disorders, [31][32][33] the association between MPV levels and the risk of BPH has not been examined in previous studies. According to the current study's findings, there is no association between MPV levels and the risk of BPH.…”

Neutrophil/Lymphocyte Ratio (NLR) and Lym-phocyte/CRP ratio (LCR) are Reliable Pre-dictors of Adverse Out-comes in High-Altitude COVID-19 Patients

“…Traditionally, the NLR has been used as a predictor of morbidity and mortality in critically ill patients, including cancer 42 , heart disease 43 , and sepsis 44 . More recently, the NLR was also shown to predict the prognosis of patients with COVID-19 45,46 The LCR, another circulating biomarker, has also been investigated as a predictor of COVID-19 severity.…”

Microbiological and Clinical Findings of SARS-CoV-2 Infection after 2 Years of Pandemic: From Lung to Gut Microbiota

“…The most common laboratory test alterations are as follows: lymphocytopenia, increase in transaminases, C-reactive protein, interleukin-6 (IL-6), CPK, LDH, prothrombin time, ferritin, creatinine and D-dimer. Of importance, in the pediatric population, a reduction in lymphocyte counts is reported in about 16% of cases [ 41 ], while alteration of CK-MB values is reported in 37% of cases; out of these, over 80% of these alterations were observed in children <1 year of age. This evidence may suggest greater attention to myocardial damage in the pediatric population, especially in children <1 year of age.…”