Neutrophil-to-lymphocyte ratio and C-reactive protein–to–albumin ratio as prognostic factors for unresectable advanced or recurrent gastric cancer

Namikawa, Tsutomu; Shimizu, Shigeto; Yokota, Keiichiro; Tanioka, Nobuhisa; Munekage, Masaya; Uemura, Sunao; Maeda, Hiromichi; Kitagawa, Hiroyuki; Kobayashi, Mariko; Hanazaki, Kazuhiro

doi:10.1007/s00423-021-02356-w

Cited by 12 publications

(15 citation statements)

References 38 publications

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“…It is widely accepted that the combined application of clinical factors might provide more information than either factor alone. Such markers have been applied for the diagnostic and prognosis in GC patients, including neutrophil-to-lymphocyte ratio (NLR) [28,29], platelet-to-lymphocyte ratio (PLR) [30], and Creactive protein/albumin ratio (CAR) [31]. Moreover, it was reported that the concomitant existence of NI and lymphovascular invasion might serve as an independent prognostic factor for DFS and OS in GC patients.…”

Section: Discussionmentioning

confidence: 99%

Neural invasion is an independent prognostic factor in young and lymph node negative gastric cancer patients underwent curative gastrectomy

Wang

Xia

Jiang

et al. 2022

Preprint

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Background: The prognostic significance of neural invasion (NI) in gastric cancer (GC) has not been established. This study is to investigate the characteristic and prognostic value of NI in GC.Methods: 592 patients who had undergone gastrectomy for GC were retrospectively analyzed. NI was defined when cancer cells infiltrated into the perineurium or neural fascicles by hematoxylin and eosin staining of surgical specimens. NI and the other clinical factors were analyzed.Results: NI was detected in 270 of the 592 patients. NI was associated with tumor size, site, depth of invasion, lymph node metastasis, TNM stage, tumor differentiation, Lauren classification, and blood vessel invasion. NI was associated with the overall survival. Multivariate analysis indicated that NI was not an independent prognostic factor for total patients, while NI independently predicted prognosis for age<60 and lymph node metastasis negative patients by subgroup analysis. Concomitant existence of NI with tumor size ≥3cm, TNM stage III, or diffused Lauren classification independently predicted prognosis.Conclusions: The frequency of NI is high in GC patients and increases with disease progression. NI is related to poor survival in GC patients who underwent curative gastrectomy and provides independent prognostic value for young and lymph node metastasis negative patients.

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Section: Discussionmentioning

confidence: 99%

Neural invasion is an independent prognostic factor in young and lymph node negative gastric cancer patients underwent curative gastrectomy

Wang

Xia

Jiang

et al. 2022

Preprint

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“…A previous study suggested that the platelet-lymphocyte ratio (PLR) may provide a reliable and individualized prediction of tumor recurrence in HCC patients after radiofrequency ablation (RFA) (12). Other inflammatory-based prognostic indices, notably neutrophil-to-lymphocyte ratio (NLR), g-glutamyl transferase/alanine aminotransferase ratio (GGT/ALT), and the aspartate aminotransferase/platelet count ratio index (APRI), have been studied for their prognostic roles for various cancers (13)(14)(15). A previous study found that high NLR is associated with poor survival in patients with unresectable and recurrent gastric cancer (14), and a high preoperative NLR stood for poor prognostic factor in HCC patients after curative resection while some were in doubt.…”

Section: Introductionmentioning

confidence: 99%

“…Other inflammatory-based prognostic indices, notably neutrophil-to-lymphocyte ratio (NLR), g-glutamyl transferase/alanine aminotransferase ratio (GGT/ALT), and the aspartate aminotransferase/platelet count ratio index (APRI), have been studied for their prognostic roles for various cancers (13)(14)(15). A previous study found that high NLR is associated with poor survival in patients with unresectable and recurrent gastric cancer (14), and a high preoperative NLR stood for poor prognostic factor in HCC patients after curative resection while some were in doubt. Preoperative NLR could predict survival better than the conventional alpha-fetoprotein (AFP) in HCC patients after curative resection (16,17), and NLR was an accurate prognostic marker for OS and PFS of unresectable intermediate and advanced HCC patients on apatinib treatment (18).…”

Section: Introductionmentioning

confidence: 99%

Preoperative Prognostic Nutritional Index and Neutrophil-to-Lymphocyte Ratio Predict Survival Outcomes of Patients With Hepatocellular Carcinoma After Curative Resection

Feng

et al. 2022

Front. Oncol.

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Increasing evidence indicates that preoperative prognostic indices can serve as independent predictors of survival in patients with cancer. However, the applicability of these indices in patients with hepatocellular carcinoma (HCC) is controversial. This study aims to investigate the prognostic value of these indices in patients with HCC after curative hepatectomy. We retrospectively analyzed the data of 215 patients who underwent curative resection for HCC. Prognostic indices including prognostic nutritional index (PNI) and neutrophil-to-lymphocyte ratio (NLR) were evaluated by comparing by the area under the curve (AUC). Univariate analysis and multivariate analysis were performed to identify independent prognostic factors. Additionally, risk factors were combined to predict the survival of patients. We found that serum albumin concentration, tumor diameter, tumor stage, degree of differentiation, PNI, and NLR were independent prognostic factors for overall survival (OS). Vascular invasion, tumor stage, degree of differentiation, and PNI were independent prognostic factors for recurrence-free survival (RFS). The cutoff value of the PNI and NLR was 43.75 and 3.29, respectively. Patients with low NLR and high PNI had the best outcomes, potentially indicative of the intensive antitumor effects of the immune system. Moreover, patients with at least three risk factors had a significantly lower OS and RFS compared with those with two or fewer risk factors. This new nomogram based on PNI and NLR may provide an accessible and individualized prediction of survival and recurrence for HCC patients.

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“…Gastric cancer is a severe threat worldwide, is the fth most common cancer and the third leading cause of cancer-associated death globally, and is the second most frequent cause of cancer-associated death in Japan [1,2]. The nutritional status of patients with gastric cancer who require surgery for curative resection is deeply involved in not only the postoperative course but also the patients' prognoses [3].…”

Section: Introductionmentioning

confidence: 99%

Association between serum zinc levels and clinicopathological characteristics in patients with gastric cancer

Namikawa

Utsunomiya

Yokota

et al. 2022

Preprint

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Purpose This study aimed to evaluate the association between clinicopathologic features and serum zinc levels in preoperative patients with gastric cancer. Methods The study enrolled 83 patients scheduled for gastric cancer surgery at the Kochi Medical School. Clinical data were obtained to investigate associations between clinicopathological features, including nutritional indicators and serum zinc levels. Serum zinc deficiency was defined as serum zinc level < 80 µg/dL. Results The median zinc level of the 83 patients was 73 µg/dL (range, 20–152 µg/dL), and serum zinc deficiency was present in 66.3% of patients. Albumin was significantly lower in the zinc low level group than in the normal group (3.9 g/dL vs. 4.4 g/dL, P < 0.001), and the median serum zinc level was significantly lower in the albumin < 4.1 g/dL group than in the albumin ≥ 4.1 g/dL group (69 µg/dL vs. 82 µg/dL, P < 0.001). Lymphocyte count was significantly lower in the zinc low level group than in the normal group (1500 vs. 1810 years, P = 0.041). The median serum zinc level was significantly lower in the age ≥ 74 group than in the age < 74 (71 µg/dL vs. 76 µg/dL, P = 0.002). Serum zinc levels showed a significant positive correlation with serum albumin (r = 0.637, P = 0.009). Conclusions Serum zinc deficiency was found in 66.3% of preoperative patients with gastric cancer, which was highly correlated with serum albumin.

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Neutrophil-to-lymphocyte ratio and C-reactive protein–to–albumin ratio as prognostic factors for unresectable advanced or recurrent gastric cancer

Cited by 12 publications

References 38 publications

Neural invasion is an independent prognostic factor in young and lymph node negative gastric cancer patients underwent curative gastrectomy

Neural invasion is an independent prognostic factor in young and lymph node negative gastric cancer patients underwent curative gastrectomy

Preoperative Prognostic Nutritional Index and Neutrophil-to-Lymphocyte Ratio Predict Survival Outcomes of Patients With Hepatocellular Carcinoma After Curative Resection

Association between serum zinc levels and clinicopathological characteristics in patients with gastric cancer

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