Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios predict chemotherapy outcomes and prognosis in patients with colorectal cancer and synchronous liver metastasis

Wu, Yuchen; Liu, Cong; Zhao, Jiang; Li, Yang; Liu, Fangqi; Zheng, Hua; Wang, Zhimin; Xu, Ye

doi:10.1186/s12957-016-1044-9

Cited by 76 publications

(73 citation statements)

References 28 publications

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“…NPS was calculated as follows: patients with a neutrophil count ≤7 × 10 3 /μL and a platelet count ≤40 × 10 4 /μL scored 0, patients with a neutrophil count >7 × 10 3 /μL or a platelet count of >40 × 10 4 /μL scored 1, and patients with a neutrophil count >7 × 10 3 /μL and a platelet count >40 × 10 4 /μL scored 2, as previously described . The cutoff value of each marker was defined as 0.5 mg/dL, 3.5 g/dL, 3, 150, 900, 3, 45, and score 1 or 2, respectively, based on previous evidence.…”

Section: Methodsmentioning

confidence: 99%

Close Relationship Between Immunological/Inflammatory Markers and Myopenia and Myosteatosis in Patients With Colorectal Cancer: A Propensity Score Matching Analysis

Okugawa

Toiyama

Yamamoto

et al. 2018

J Parenter Enteral Nutr

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Background The systemic inflammatory response (SIR) via host‐tumor interactions has been termed the seventh hallmark of cancer, and several studies demonstrated that SIR might be a pivotal mediator for progression of cancer cachexia. The objective of this study was to clarify the correlation between sarcopenia and SIR in patients with colorectal cancer (CRC). Methods A total of 308 patients with CRC were enrolled in this study. Preoperative psoas muscle mass index and intramuscular adipose tissue content were evaluated using preoperative computed tomographic images, and the correlation between body composition status and several SIR markers, including C‐reactive protein (CRP), serum albumin level, neutrophil‐lymphocyte ratio, platelet‐lymphocyte ratio, and systemic immune‐inflammation index (SII) was assessed using statistical methods. Results Whereas preoperative myosteatosis was not correlated with clinicopathological factors except for aging and the presence of lymphovascular invasion, preoperative myopenia was significantly associated with well‐established clinicopathological factors. Furthermore, the presence of myopenia was significantly correlated with elevated CRP, SII, and neutrophil‐platelet score, and decreased lymphocyte‐monocyte ratio, prognostic nutrition index, and serum albumin level. Logistic regression analysis revealed that an elevated CRP concentration was an independent risk factor for the presence of preoperative myopenia (odds ratio [OR] 2.49, 95% CI: 1.31–4.72; P = .005). Furthermore, these findings were validated using propensity score matching analysis (OR 2.35, 95% CI: 1.17–4.75; P = .017). Conclusion Quantification of preoperative CRP could identify patients at high risk for development of myopenia who will likely require individualized treatment plans, including postoperative nutrition intervention, rehabilitation, and oncological follow‐up in patients with CRC.

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Section: Methodsmentioning

confidence: 99%

Close Relationship Between Immunological/Inflammatory Markers and Myopenia and Myosteatosis in Patients With Colorectal Cancer: A Propensity Score Matching Analysis

Okugawa

Toiyama

Yamamoto

et al. 2018

J Parenter Enteral Nutr

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“…Other important factors include the increase of platelet-associated inflammatory reactions, decreased antitumor response due to relative scarcity of lymphocytes, and tumoral growth and spread induced by various epithelial and endothelial growth factors secreted by circulating active platelets. 4,5,6,7,8,9,10 When the common effect of age, sex, and comorbid diseases was examined, it was found that PLR was significantly higher in patients with liver metastasis independent of these three parameters (p<0.001). The most important prognostic marker in colon cancer is cancer stage, and liver metastasis detected preoperatively corresponds to a more advanced stage.…”

Section: Discussionmentioning

confidence: 99%

“…7 Another use of PLR in colorectal cancers is to evaluate response to chemotherapy. In a study conducted with metastatic colorectal cancer patients, Wu et al 10 reported that normalization of PLR value is a marker of good prognosis in the assessment of response to chemotherapy. There is only one study in the literature evaluating liver metastases of colorectal cancers and PLR.…”

Section: Discussionmentioning

confidence: 99%

“…6,8,9 Previous studies have focused on changes in PLR at different stages of colon cancer and its effect on prognosis, response to chemotherapy, and recurrence time. 4,5,6,7,8,9,10 In this study, we aimed to determine the utility of PLR at time of admission in predicting hepatic metastasis and lymph node positivity in patients who have undergone colorectal surgery.…”

Section: Introductionmentioning

confidence: 99%

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Clinical Value of Platelet-to-Lymphocyte Ratio in Predicting Liver Metastasis and Lymph Node Positivity of Colorectal Cancer Patients

Anuk¹,

Yıldırım²

2017

TJCD

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Amaç: Kolon kanserine bağlı mortalite azalsa da hala yüksektir. Kolonoskopinin artan kullanımı, cerrahi teknolojide ilerlemeler, kemoradyoterapi protokollerinin standardizasyonu metastatik olgularda sağkalımı arttırmıştır. Enflamasyon, birçok kanserin gelişiminde önemli rol oynar. Plateletlenfosit oranı (PLO) gibi birçok belirteç kanserde kötü prognoz ile ilişkilendirilmiştir. Çalışmamızda preoperatif bakılan PLO'nun kolon kanserli hastalarda karaciğer metastazını ve lenf nodu pozitifliğini öngörebilirliğini saptamayı amaçladık. Yöntem: Mart 2010 ve Eylül 2016 tarihleri arasında kolorektal kanser tanısı konularak operasyona alınan hastaların dosyaları retrospektif olarak incelendi. Hastaların demografik verileri, preoperatif PLO, intraoperatif bulgular ve postoperatif tümör-nod-metastaz evrelemesine göre histopatoloji raporları kaydedildi. Hastalar karaciğer metastazı saptananlar grup 1a ve saptanmayanlar grup 1b olarak 2 gruba ayrıldı. Aynı şekilde lenf nodu pozitifliği saptananlar grup 2a ve saptanmayanlar grup 2b olarak alt gruba ayrıldı. Sonuçlar SPSS programı ile analiz edildi. Bulgular: Yüz elli iki hastada erkek/kadın oranı 1,53 idi. En sık rektosigmoid bölgede kanser tespit edildi. Sekiz hastada ailesel kolorektal kanser, 66 hastada komorbid hastalık tespit edildi. Postoperatif 30 günlük dönemde sekiz hastada erken mortalite gözlendi. Otuz bir hastada karaciğer metastazı mevcuttu. PLO'nun gruplar arası karşılaştırmasında, metastaz saptanan grupta PLO değeri, anlamlı şekilde yüksekti (p<0,001). Yaş, cinsiyet ÖZ ABSTRACTAim: Colorectal cancer related mortality is still high. The widespread use of colonoscopy, surgical advancements, and standardized use of chemotherapeutic agents has increased survival rates in metastatic cases. Inflammation is the main etiological factor in a variety of cancers. Plateletto-lymphocyte ratio (PLR), one the most studied biochemical parameters, has been shown as a poor prognostic factor. In this study, our aim was to determine the predictive value of PLR on liver metastasis and lymph node positivity in colorectal patients. Method: The data of patients who were diagnosed with colorectal cancer and underwent surgery between March 2010 and September 2016 were analyzed retrospectively. Demographic characteristics, preoperative PLR, intraoperative findings, and tumor-node-metastasis stages were recorded. Patients with liver metastasis comprised group 1a and those without liver metastasis were group 1b; patients were also sorted into groups 2a and 2b based on lymph node positivity or negativity, respectively. Results: A total of 152 patients were included in the study and the male/female ratio was 1.53. Most of patients had rectosigmoid junction tumors. Eight patients had familial history of colorectal cancer and 66 patients had comorbid conditions. Eight patients had early 30-day mortality. Thirty-one patients had liver metastasis. Patients with liver metastasis (group 1a) had significantly higher PLR values when compared to group 1b (p<0.001). When age, gender and comorbid disease...

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“…Several reports showed that NLR and PLR might be useful as predictors of outcome [32][33][34]. Neutrophil and Significant p values are in bold.…”

Section: Discussionmentioning

confidence: 99%

Neutrophil, Platelets, and Eosinophil to Lymphocyte Ratios Predict Gleason Score Upgrading in Low-Risk Prostate Cancer Patients

et al. 2018

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Background: Several biochemical and clinical markers have been proposed for selecting patients for active surveillance (AS). However, some of these are expensive and not easily accessible. Moreover, currently about 30% of patients on AS harbor aggressive disease. Hence, there is an urgent need for other tools to accurately identify patients with low-risk prostate cancer (PCa). Patients: We retrospectively reviewed the medical records of 260 patients who underwent radical prostatectomy and were eligible for AS according to the following criteria: clinical stage T2a or less, prostate-specific antigen level < 10 ng/mL, 2 or fewer cores involved with cancer, Gleason score (GS) ≤6 grade, and prostate-specific antigen density < 0.2 ng/mL/cc. Methods: Univariate and multivariate analyses were performed to evaluate the association of patient and tumor characteristics with reclassification, defined as upstaged (pathological stage >pT2) and upgraded (GS ≥7) disease. A base model (age, prostate-specific antigen, prostate volume, and clinical stage) was compared with models considering neutrophil to lymphocyte ratio (NLR) or platelets to lymphocyte ratio (PLR), monocyte to lymphocyte (MLR), and eosinophil to lymphocyte ratio (ELR). OR and 95% CI were calculated. Finally, a decision curve analysis was performed. Results: Univariate and multivariate analyses showed that NLR, PLR, and ELR upgrading were significantly associated with upgrading (ORs ranging from 2.13 to 4.13), but not with upstaging except for MLR in multivariate analysis, showing a protective effect. Conclusion: Our results showed that NLR, PLR, and ELR are predictors of Gleason upgrading. Therefore, these inexpensive and easily available tests might be useful in the assessment of low-risk PCa, when considering patients for AS.

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Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios predict chemotherapy outcomes and prognosis in patients with colorectal cancer and synchronous liver metastasis

Cited by 76 publications

References 28 publications

Close Relationship Between Immunological/Inflammatory Markers and Myopenia and Myosteatosis in Patients With Colorectal Cancer: A Propensity Score Matching Analysis

Close Relationship Between Immunological/Inflammatory Markers and Myopenia and Myosteatosis in Patients With Colorectal Cancer: A Propensity Score Matching Analysis

Clinical Value of Platelet-to-Lymphocyte Ratio in Predicting Liver Metastasis and Lymph Node Positivity of Colorectal Cancer Patients

Neutrophil, Platelets, and Eosinophil to Lymphocyte Ratios Predict Gleason Score Upgrading in Low-Risk Prostate Cancer Patients

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