Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios as inflammation markers in patients with papilledema due to idiopathic intracranial hypertension

Yılmaz, Mevlüt; Ceylan, OsmanMelih; Çelikay, Osman; Köylü, MehmetTalay; Turan, Aynur

doi:10.4103/ijo.ijo_2030_20

Cited by 5 publications

(4 citation statements)

References 41 publications

(56 reference statements)

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“…Another important (though less commonly evoked) function of platelets is their active participation in antiinfectious responses (17). Additionally, platelets orchestrate the immune response by modulating several immune cells (18,19). Presently, HLA-B27, acute-phase reactants, clinical characteristics, and radiographically detected changes in images are the main ways to diagnose AS.…”

Section: Discussionmentioning

confidence: 99%

Platelet-to-Lymphocyte Ratio as an Independent Factor Was Associated With the Severity of Ankylosing Spondylitis

Liang

Chen

et al. 2021

Front. Immunol.

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The study was aimed to determine the association of the platelet-lymphocyte ratio (PLR) with the disease activity of ankylosing spondylitis (AS). A total of 275 patients, including 180 AS patients and 95 non-AS patients, participated in the study. We assessed a full blood count for each participant. Platelet to monocyte ratio (PMR), monocytes to lymphocyte ratio (MLR), monocyte to neutrophil ratio (MNR), platelet to lymphocyte ratio (PLR), neutrophil to lymphocyte ratio (NLR), and platelet to neutrophil ratio (PNR) were calculated. LASSO and logistic regression analyses were performed to establish the nomogram. Receiver operating characteristic (ROC) analysis was performed to evaluate the clinical value of the nomogram. We constructed a novel nomogram, which incorporated easily accessible clinical characteristics like sex, PLR, WBC, EOS, and ESR for AS diagnosis. The AUC value of this nomogram was 0.806; also, the calibration curves indicated a satisfactory agreement between nomogram prediction and actual probabilities. Furthermore, PLR was positively correlated with the severity of AS. PLR was identified as an independent factor for the diagnosis of AS and was associated with the severity of AS.

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Section: Discussionmentioning

confidence: 99%

Platelet-to-Lymphocyte Ratio as an Independent Factor Was Associated With the Severity of Ankylosing Spondylitis

Liang

Chen

et al. 2021

Front. Immunol.

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“…Moreover, we found that PLR is an independent predictor of 30-day mortality in PBSH patients. The PLR has been reported to be a biomarker in many diseases, such as idiopathic intracranial hypertension, acute myocardial infarction, and inflammatory response 22–24. Our study investigates the predictive value of routine blood biomarkers for intracranial hematoma.…”

Section: Discussionmentioning

confidence: 99%

Development and Validation of a Prediction Model for 30-Day Mortality and Functional Outcome in Patients with Primary Brainstem Hemorrhage

Cai¹,

Yan²,

Chen³

et al. 2023

Cerebrovasc Dis

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Introduction: Primary brainstem hemorrhage (PBSH) is the most fatal subtype of intracerebral hemorrhage and is associated with poor prognosis. We aimed to develop a prediction model for predicting 30-day mortality and functional outcome in patients with PBSH. Methods: We reviewed records of 642 consecutive patients with first-time PBSH from three hospitals between 2016 and 2021. Multivariate logistic regression was used to establish a nomogram in a training cohort. Cutoff points of the variables were determined by receiver operating characteristic curve analysis, and certain points were assigned to these predictors to produce the PBSH score. The nomogram and PBSH score were compared with other scoring systems for PBSH. Results: Five independent predictors, comprised of temperature, pupillary light reflex, platelet-to-lymphocyte ratio, Glasgow Coma Scale (GCS) score on admission, and hematoma volume, were incorporated to construct the nomogram. The PBSH score consisted of 4 independent factors with individual points assigned as follows: temperature, ≥38°C (=1 point), <38°C (=0 points); pupillary light reflex, absence (=1 point), presence (=0 points); GCS score 3–4 (=2 points), 5–11 (=1 point), and 12–15 (=0 points); PBSH volume >10 mL (=2 points), 5–10 mL (=1 point), and <5 mL (=0 points). Results showed that the nomogram was discriminative in predicting both 30-day mortality (area under the ROC curve [AUC] of 0.924 in the training cohort, and 0.931 in the validation cohort) and 30-day functional outcome (AUC of 0.887). The PBSH score was discriminative in predicting both 30-day mortality (AUC of 0.923 in the training cohort and 0.923 in the validation cohort) and 30-day functional outcome (AUC of 0.887). The prediction performances of the nomogram and the PBSH score were superior to the intracranial hemorrhage (ICH) score, primary pontine hemorrhage (PPH) score, and new PPH score. Conclusions: We developed and validated two prediction models for 30-day mortality and functional outcome in patients with PBSH. The nomogram and PBSH score could predict 30-day mortality and functional outcome in PBSH patients.

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“…The linear relationship between papilledema grade and the NLR and PLR, in particular, indicated that, as the ICP increased, the levels of inflammatory biomarkers also increased. 32 In this context, when examining patients with CVST, it is important to consider the effect of increased ICP on inflammatory biomarkers. The thrombus scoring system developed by Wang et al, 17 which we used to determine the thrombus burden, appears to be the most suitable and sensitive scoring system among those previously described.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory biomarkers are correlated with thrombus burden in cerebral venous sinus thrombosis

Yaman Kula,

Kurtoğlu,

Güzel

et al. 2024

Arq Neuropsiquiatr

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Background Increasing evidence suggests that inflammatory biomarkers play a significant role in cerebral venous sinus thrombosis (CVST). The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) are related to thrombotic conditions and indicators of systemic inflammation. Objective To analyze the correlation between inflammatory biomarkers and the extent of thrombus, determined by the CVST-Score. Methods A total of 40 patients with CVST (24 female subjects; 60%) and 40 age- and sex-matched healthy controls were retrospectively evaluated. Inflammatory biomarkers, including C-reactive protein (CRP), PLR, NLR, MLR, and the CVST-Score, were recorded to assess the relationship between biomarkers and thrombus burden. The patients were grouped according to symptom duration (group 1: 0–3 days; group 2: 4–7 days; and group 3: 8–30 days) to compare biomarker levels. Results The CRP, NLR, and PLR were significantly higher in the CVST group (p < 0.001; p = 0.003; p = 0.014 respectively). The NLR and PLR presented a significant positive correlation with the CVST-Score (p = 0.003, r = 0.464; p = 0.040, r = 0.326 respectively). The NLR was significantly higher in group 1 compared with groups 2 and 3 (p = 0.016 and p = 0.014 respectively). In group 1, there was a stronger positive correlation between the CVST-Score and the NLR (p = 0.026, r = 0.591) and the PLR (p = 0.012, r = 0.648). The multiple linear regression analysis revealed that the NLR is a key factor in predicting the CVST-Score (p = 0.019). Conclusion The NLR and PLR are associated with thrombus burden in CVST, especially in patients admitted to the hospital in the early stages. The NLR is an independent factor to predict the thrombus burden in CVST.

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Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios as inflammation markers in patients with papilledema due to idiopathic intracranial hypertension

Cited by 5 publications

References 41 publications

Platelet-to-Lymphocyte Ratio as an Independent Factor Was Associated With the Severity of Ankylosing Spondylitis

Platelet-to-Lymphocyte Ratio as an Independent Factor Was Associated With the Severity of Ankylosing Spondylitis

Development and Validation of a Prediction Model for 30-Day Mortality and Functional Outcome in Patients with Primary Brainstem Hemorrhage

Inflammatory biomarkers are correlated with thrombus burden in cerebral venous sinus thrombosis

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