Neutrophil-to-lymphocyte and fibrinogen-to-albumin ratios may be indicators of worse outcomes in ICU patients with COVID-19

Atlas, Ahmet; Altay, Nuray; Karahan, Mahmut Alp; Pehlivan, Veli Fahri; Pehlivan, Başak; Duran, Erdoğan; Erol, Mehmet Kenan

doi:10.28982/josam.930254

Cited by 6 publications

(4 citation statements)

References 33 publications

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“…Although these data were not calculated for every patient, they suggest that the neutrophil-to-lymphocyte ratio increased in patients who died. Atlas et al investigated COVID-19 patients who were followed-up in the intensive care unit, and they showed that an increase in the neutrophil-to-lymphocyte ratio, ddimer, and CRP levels was associated with an adverse outcome [22]. In our study, an increase in neutrophils, d-dimer, and CRP and a decrease in lymphocyte levels were observed after CP in patients who died, which is consistent with Atlas et al's results.…”

Section: Discussionsupporting

confidence: 91%

Comparison of hematological and biochemical parameters in COVID-19 pneumonia patients before and after convalescent plasma (CP) treatment

Polat

URKMEZ>

2022

J Surg Med

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Background/Aim: Convalescent plasma (CP) therapy, which includes processing and administering antibody-rich plasma from recovered patients to sick patients, is used for passive immunity in COVID-19 pneumonia patients in addition to antivirals and antibiotics. This study aimed to assess whether CP treatment significantly affects hyperviscosity and COVID-19 prognosis-related blood parameters. Methods: This study was a single-center retrospective cohort study. Ninety-seven patients with COVID-19 polymerase chain reaction (PCR)-positive results and pneumonia observed on thoracic computed tomography (CT) were included. Patients’ ferritin, d-dimer, C-reactive protein (CRP), and complete blood count levels before and after CP administration were compared. Results: Ferritin, d-dimer, white blood cell (WBC), neutrophil, and plateletcrit (PCT) levels and the platelet distribution width (PDW) were significantly higher and there was a significant decrease in the CRP level after CP treatment compared to before CP (P < 0.05). Ferritin, d-dimer, and CRP values measured after CP were higher in deceased patients than in survivors (P = 0.001, P = 0.007, and P < 0.001, respectively) Conclusion: Ferritin, d-dimer, WBC, and neutrophil levels, which we expected to decrease on the basis of the COVID-19 prognosis, unfortunately increased, and only CRP levels decreased. However, we found that these increases were more pronounced in patients who died. Considering these prognostic factors, the findings of our study suggest that CP treatment has no effect on the COVID-19 disease course and may lead to a worse prognosis.

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Section: Discussionsupporting

confidence: 91%

Comparison of hematological and biochemical parameters in COVID-19 pneumonia patients before and after convalescent plasma (CP) treatment

Polat

URKMEZ>

2022

J Surg Med

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“…It is stated in accordance with similar research. 16 In conclusion, we can say that the obtained results are in accordance with the expected, i.e. pathophysiological processes in critically ill patients with COVID-19 infection in ICU.…”

Section: Discussionsupporting

confidence: 85%

Prognostic significance of inflammatory scoring systems in critically ill patients with COVID-19 infection

Mihić

Maričić

Tolj

et al. 2022

Med. Jadert. (Online)

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Aim: The outbreak of novel coronavirus pneumonia that was first detected in Wuhan in December 2019 resulted in a worldwide pandemic. Approximately 25% of confirmed cases developed a severe disease and the need for intensive care unit admission. The aim of this study was to determine the role of three inflammatory scoring systems, C-reactive protein/albumin ratio, fibrinogen/albumin ratio, C-reactive protein/lymphocyte ratio and their association with survival, comorbidities, and the occurrence of additional complications in the intensive care of these patients. Materials and methods: This retrospective study was conducted based on data collected by the Department of Respiratory Center. Ethical approval for the study was obtained from the Ethics Committee of Osijek University Hospital. This study analysed data retrospectively between October and December 2020, and included 137 critically ill patients with a diagnosis of COVID-19. Results: Data analysis of three examined inflammatory points of the system, below and above the median found a significant association in the group below the median C-reactive protein/albumin ratio with the presence of complications (p= 0,039) in the group above the median in the study of fibrinogen/albumin ratio found a significant association with sepsis (p=0,043). In the group of participants who were above its median in terms of C-reactive protein/lymphocyte ratio, there were more of those with the development of acute kidney injury (p=0,014), and sepsis (p=0,009). Conclusion: Inflammatory scoring systems, C-reactive protein/albumin ratio, fibrinogen/albumin ratio and C‐reactive protein/lymphocyte ratio represent an independent prognostic indicator of the clinical course in critically ill patients with COVID-19 infection.

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“…[7] Numerous studies have reported that the fibrinogen-albumin ratio is closely associated with the disease course and mortality in COVID-19 cases. [8][9][10][11] The immune system and nutritional level are closely linked to an individual's susceptibility to infections. Although hypoalbuminemia occurs in cases of inflammation and malnu-trition, lymphopenia is one of the most common laboratory findings in acute viral infections.…”

Section: Introductionmentioning

confidence: 99%

The Relationship Between OR-PNI Score and Disease Course in Coronavirus-19 Infection

Türker

2024

Comprehensive Med

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Objective: Prognostic nutritional index (PNI), fibrinogen/albumin ratio index (FARI), and OR-PNI scores (obtained by using the PNI score, oxygen saturation, and computed tomography findings) were examined. Materials and Methods:This study was conducted with 486 patients.Results: : A FARI score of >18.08 predicted mortality with a sensitivity of 71.8% and a specificity of 71.1%. In the receiver operating characteristic analysis for PNI and OR-PNI scores, p-values were <0.001, but the area under the curve values were found to be 0.151 and 0.072, respectively. Conclusion:FARI score is a parameter that predicts mortality; PNI and OR-PNI failed to predict mortality. In addition, PNI and OR-PNI values were found to be closely related to the course of the disease.

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Neutrophil-to-lymphocyte and fibrinogen-to-albumin ratios may be indicators of worse outcomes in ICU patients with COVID-19

Abstract: to-lymphocyte and fibrinogen-to-albumin ratios may be indicators of worse outcomes in ICU patients with COVID-19.

Cited by 6 publications

References 33 publications

Comparison of hematological and biochemical parameters in COVID-19 pneumonia patients before and after convalescent plasma (CP) treatment

Comparison of hematological and biochemical parameters in COVID-19 pneumonia patients before and after convalescent plasma (CP) treatment

Prognostic significance of inflammatory scoring systems in critically ill patients with COVID-19 infection

The Relationship Between OR-PNI Score and Disease Course in Coronavirus-19 Infection

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