Neutrophil–T cell crosstalk in inflammatory bowel disease

Kvedaraite, Egle

doi:10.1111/imm.13391

Cited by 30 publications

(27 citation statements)

References 83 publications

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“…Investigating associations between lesion LCH cells and other signaling factors, we found that the proportion of LCH cells in lesions correlated with plasma IL-11 (a cancer mediator), soluble CD27 (sCD27; a T cell activator) and plasma CCL2 (MCP-1; monocyte chemoattractant protein-1) ( Figure 1B.i–iii ). In addition to this study, it is already established that plasma IL-23 and IL-12p40, the two subunits of IL-23 - a well-established driver of chronic tissue inflammation ( 27 ), correlate with the proportion of LCH cells in the CD11c+ compartment of LCH lesions ( 19 ). The influence of plasma signaling factors on LCH cell phenotype and pathogenesis may be more complex than originally thought, and future studies addressing soluble and cellular immunological phenotypes during AD and NAD in LCH, both at the lesion site and in circulation, are warranted.…”

Section: Resultsmentioning

confidence: 79%

“…In addition to this study, it is already established that plasma IL-23 and IL-12p40, the two subunits of IL-23 -a well-established driver of chronic tissue inflammation (27), correlate with the proportion of LCH cells in the CD11c+ compartment of LCH lesions (19). The influence of plasma signaling factors on LCH cell phenotype and pathogenesis may be more complex than originally thought, and future studies addressing soluble and cellular immunological phenotypes during AD and NAD in LCH, both at the lesion site and in circulation, are warranted.…”

Section: Resultsmentioning

confidence: 80%

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Plasma Signaling Factors in Patients With Langerhans Cell Histiocytosis (LCH) Correlate With Relative Frequencies of LCH Cells and T Cells Within Lesions

et al. 2022

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Langerhans cell histiocytosis (LCH) lesions contain an inflammatory infiltrate of immune cells including myeloid-derived LCH cells. Cell-signaling proteins within the lesion environment suggest that LCH cells and T cells contribute majorly to the inflammation. Foxp3+ regulatory T cells (Tregs) are enriched in lesions and blood from patients with LCH and are likely involved in LCH pathogenesis. In contrast, mucosal associated invariant T (MAIT) cells are reduced in blood from these patients and the consequence of this is unknown. Serum/plasma levels of cytokines have been associated with LCH disease extent and may play a role in the recruitment of cells to lesions. We investigated whether plasma signaling factors differed between patients with active and non-active LCH. Cell-signaling factors (38 analytes total) were measured in patient plasma and cell populations from matched lesions and/or peripheral blood were enumerated. This study aimed at understanding whether plasma factors corresponded with LCH cells and/or LCH-associated T cell subsets in patients with LCH. We identified several associations between plasma factors and lesional/circulating immune cell populations, thus highlighting new factors as potentially important in LCH pathogenesis. This study highlights plasma cell-signaling factors that are associated with LCH cells, MAIT cells or Tregs in patients, thus they are potentially important in LCH pathogenesis. Further study into these associations is needed to determine whether these factors may become suitable prognostic indicators or therapeutic targets to benefit patients.

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Section: Resultsmentioning

confidence: 79%

Section: Resultsmentioning

confidence: 80%

Plasma Signaling Factors in Patients With Langerhans Cell Histiocytosis (LCH) Correlate With Relative Frequencies of LCH Cells and T Cells Within Lesions

et al. 2022

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“…In addition, FMT and biologics can jointly target the crosstalk between Th17 cells and neutrophils infiltrating the intestinal lamina propria to alleviate intestinal inflammation ( Pelletier et al, 2010 ). In the colonic lamina propria of patients with IBD, Th17 cells highly express IL-8 and mediate the recruitment of tissue-infiltrating neutrophils, which have been proven to be the main producers of IL-23 in the intestine in an IL-8/CXCR1/CXCR2-dependent manner ( Kvedaraite et al, 2016 ; Kvedaraite, 2021 ). These tissue-infiltrating neutrophils, in turn, present antigens and activate pathogenic Th17 cells with the aid of IL-23, thereby building a pro-inflammatory microenvironment and maintaining a sustained inflammatory response in the intestine ( Kvedaraite, 2021 ).…”

Section: Potential Application Of Gut Microbiota In the Biological Th...mentioning

confidence: 99%

“…In the colonic lamina propria of patients with IBD, Th17 cells highly express IL-8 and mediate the recruitment of tissue-infiltrating neutrophils, which have been proven to be the main producers of IL-23 in the intestine in an IL-8/CXCR1/CXCR2-dependent manner ( Kvedaraite et al, 2016 ; Kvedaraite, 2021 ). These tissue-infiltrating neutrophils, in turn, present antigens and activate pathogenic Th17 cells with the aid of IL-23, thereby building a pro-inflammatory microenvironment and maintaining a sustained inflammatory response in the intestine ( Kvedaraite, 2021 ). FMT decreased the number of neutrophils in the mucosal lamina propria, thereby reducing IL-23 production and antigen presentation to Th17 cells ( Burrello et al, 2018 ).…”

Section: Potential Application Of Gut Microbiota In the Biological Th...mentioning

confidence: 99%

Alterations and Potential Applications of Gut Microbiota in Biological Therapy for Inflammatory Bowel Diseases

Zhang

Feng

2022

Front. Pharmacol.

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Inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, is a chronic immune-mediated inflammatory disorder of the gastrointestinal tract that is closely associated with dysbiosis of the intestinal microbiota. Currently, biologic agents are the mainstream therapies for IBD. With the increasing incidence of IBD, limitations of biologic agents have gradually emerged during treatment. Recent studies have indicated that gut microbiota is highly correlated with the efficacy of biologic agents. This review focuses on alterations in both the components and metabolites of gut microbiota during biological therapy for IBD, systematically summarises the specific gut microbiota closely related to the clinical efficacy, and compares current predictive models for the efficacy of biologics, further highlighting the predictive value of intestinal microbiota. Based on the mechanistic analysis of faecal microbiota transplantation (FMT) and biologic agents, a new therapeutic strategy, comprising a combination of FMT and biologics, has been proposed as a promising treatment for IBD with improved efficacy.

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“…However, with the persistence of the inflammatory process, neutrophils become necessary as parts of the resolution of inflammation, the initiation of wound healing, and the return of the system to homeostasis (Kolaczkowska and Kubes;Puhl and Steffens;Ma, 2021). Neutrophils have also been shown to modulate the effects of the adaptive immune system by manipulating cytokines necessary for both B-and T-cell survival and activation (Karmakar and Vermeren., 2021;Kvedaraite, 2021). Therefore, identifying the precise cellular mechanisms that regulate neutrophil trafficking and activation is of the utmost importance, especially when it comes to manipulating the immune response for a successful therapeutic benefit.…”

Section: Introductionmentioning

confidence: 99%

Neutrophil Migratory Patterns: Implications for Cardiovascular Disease

Dahdah

Johnson

Sreejit

et al. 2022

Front. Cell Dev. Biol.

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The body’s inflammatory response involves a series of processes that are necessary for the immune system to mitigate threats from invading pathogens. Leukocyte migration is a crucial process in both homeostatic and inflammatory states. The mechanisms involved in immune cell recruitment to the site of inflammation are numerous and require several cascades and cues of activation. Immune cells have multiple origins and can be recruited from primary and secondary lymphoid, as well as reservoir organs within the body to generate an immune response to certain stimuli. However, no matter the origin, an important aspect of any inflammatory response is the web of networks that facilitates immune cell trafficking. The vasculature is an important organ for this trafficking, especially during an inflammatory response, mainly because it allows cells to migrate towards the source of insult/injury and serves as a reservoir for leukocytes and granulocytes under steady state conditions. One of the most active and vital leukocytes in the immune system’s arsenal are neutrophils. Neutrophils exist under two forms in the vasculature: a marginated pool that is attached to the vessel walls, and a demarginated pool that freely circulates within the blood stream. In this review, we seek to present the current consensus on the mechanisms involved in leukocyte margination and demargination, with a focus on the role of neutrophil migration patterns during physio-pathological conditions, in particular diabetes and cardiovascular disease.

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Neutrophil–T cell crosstalk in inflammatory bowel disease

Cited by 30 publications

References 83 publications

Plasma Signaling Factors in Patients With Langerhans Cell Histiocytosis (LCH) Correlate With Relative Frequencies of LCH Cells and T Cells Within Lesions

Plasma Signaling Factors in Patients With Langerhans Cell Histiocytosis (LCH) Correlate With Relative Frequencies of LCH Cells and T Cells Within Lesions

Alterations and Potential Applications of Gut Microbiota in Biological Therapy for Inflammatory Bowel Diseases

Neutrophil Migratory Patterns: Implications for Cardiovascular Disease

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