Neutrophil subsets and their differential roles in viral respiratory diseases

Zhang, Yuning; Wang, Quanbo; Mackay, Charles R.; Ng, Lai Guan; Kwok, Immanuel

doi:10.1002/jlb.1mr1221-345r

Cited by 14 publications

(14 citation statements)

References 281 publications

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“…An excessive inflammatory response and dysregulated neutrophil phenotype are hallmarks of COVID-19 infection 15,21,[44][45][46][47][48][49][50][51] but the molecular defects in the control of neutrophil functions are still unknown. PCNA is a highly conserved scaffolding protein originally described in the nuclei of proliferating cells as a maestro of the replication.…”

Section: Discussionmentioning

confidence: 99%

Cytosolic PCNA interacts with S100A8 and controls an inflammatory subset of neutrophils in COVID-19

Formiga

Pesenti

Ladjemi

et al. 2022

Preprint

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Neutrophils are key players in the hyperinflammatory response upon SARS-CoV-2 infection. We have previously described that cytosolic proliferating cell nuclear antigen (PCNA) controls neutrophil survival and NADPH oxidase-dependent ROS production. We here show that both PCNA and S100A8 expression and interaction were elevated in neutrophils from patients with COVID-19 compared to healthy donors and this was correlated with disease severity. Increased PCNA expression was accompanied by a decreased apoptosis and increased NADPH-oxidase activity in neutrophils from COVID-19 patients compared to healthy donors. These effects, as well as the interaction between PCNA and S100A8, were potently counteracted by T2 amino alcohol (T2AA), a PCNA inhibitor, demonstrating that the PCNA scaffold orchestrated neutrophil activation. Notably, the interaction between PCNA-S100A8 was more intense in the CD16high-CD62Llow activated neutrophil subset. We propose that PCNA-S100A8 complex acts as potential driver for neutrophil dysregulation in COVID-19 and show for the first time that the PCNA scaffold is a decisive component of both neutrophil activation and heterogeneity.

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Section: Discussionmentioning

confidence: 99%

Cytosolic PCNA interacts with S100A8 and controls an inflammatory subset of neutrophils in COVID-19

Formiga

Pesenti

Ladjemi

et al. 2022

Preprint

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“…This illustrates the double‐edged role of neutrophils in respiratory disease. An increasing number of studies in recent years have established the importance of neutrophil heterogeneity in respiratory diseases 164,165 . Specifically, the phenotype of neutrophils alters as a disease progresses 166 .…”

Section: Neutrophil Heterogeneity In Diseasesmentioning

confidence: 99%

The double‐edged role of neutrophil heterogeneity in inflammatory diseases and cancers

Zhou

Cao

et al. 2023

MedComm

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Neutrophils are important immune cells act as the body's first line of defense against infection and respond to diverse inflammatory cues. Many studies have demonstrated that neutrophils display plasticity in inflammatory diseases and cancers. Clarifying the role of neutrophil heterogeneity in inflammatory diseases and cancers will contribute to the development of novel treatment strategies. In this review, we have presented a review on the development of the understanding on neutrophil heterogeneity from the traditional perspective and a high‐resolution viewpoint. A growing body of evidence has confirmed the double‐edged role of neutrophils in inflammatory diseases and tumors. This may be due to a lack of precise understanding of the role of specific neutrophil subsets in the disease. Thus, elucidating specific neutrophil subsets involved in diseases would benefit the development of precision medicine. Thusly, we have summarized the relevance and actions of neutrophil heterogeneity in inflammatory diseases and cancers comprehensively. Meanwhile, we also discussed the potential intervention strategy for neutrophils. This review is intended to deepen our understanding of neutrophil heterogeneity in inflammatory diseases and cancers, while hold promise for precise treatment of neutrophil‐related diseases.

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“…In cases of IV infection, the cytokine IL‐8 is the most effective agent for bringing NEs from the blood vessels into the lungs. NEs can help contain IV infections, but an excessive number can cause inflammatory damage to the infected lung tissue 69,70 …”

Section: Interconnection Of Panoptosis Innate Immune Responses and In...mentioning

confidence: 99%

“…NEs can help contain IV infections, but an excessive number can cause inflammatory damage to the infected lung tissue. 69,70 NEs have a protective role during viral infections through multiple defense mechanisms, including 72 Researchers, such as Superti et al 73 have found that bovine lactoferrin can suppress IaV…”

Section: Neutrophils (Nes) and IVmentioning

confidence: 99%

Interaction among inflammasome, PANoptosise, and innate immune cells in infection of influenza virus: Updated review

Wei,

Wang,

Zhou

2023

Immunity Inflam & Disease

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BackgroundInfluenza virus (IV) is a leading cause of respiratory tract infections, eliciting responses from key innate immune cells such as Macrophages (MQs), Neutrophils, and Dendritic Cells (DCs). These cells employ diverse mechanisms to combat IV, with Inflammasomes playing a pivotal role in viral infection control. Cellular death mechanisms, including Pyroptosis, Apoptosis, and Necroptosis (collectively called PANoptosis), significantly contribute to the innate immune response.MethodsIn this updated review, we delve into the intricate relationship between PANoptosis and Inflammasomes within innate immune cells (MQs, Neutrophils, and DCs) during IV infections. We explore the strategies employed by IV to evade these immune defenses and the consequences of unchecked PANoptosis and inflammasome activation, including the potential development of severe complications such as cytokine storms and tissue damage.ResultsOur analysis underscores the interplay between PANoptosis and Inflammasomes as a critical aspect of the innate immune response against IV. We provide insights into IV's various mechanisms to subvert these immune pathways and highlight the importance of understanding these interactions to develop effective antiviral medications.ConclusionA comprehensive understanding of the dynamic interactions between PANoptosis, Inflammasomes, and IV is essential for advancing our knowledge of innate immune responses to viral infections. This knowledge will be invaluable in developing targeted antiviral therapies to combat IV and mitigate potential complications, including cytokine storms and tissue damage.

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Neutrophil subsets and their differential roles in viral respiratory diseases

Cited by 14 publications

References 281 publications

Cytosolic PCNA interacts with S100A8 and controls an inflammatory subset of neutrophils in COVID-19

Cytosolic PCNA interacts with S100A8 and controls an inflammatory subset of neutrophils in COVID-19

The double‐edged role of neutrophil heterogeneity in inflammatory diseases and cancers

Interaction among inflammasome, PANoptosise, and innate immune cells in infection of influenza virus: Updated review

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