Neutrophil sequestration in the lung following acute aortic occlusion starts during ischaemia and can be attenuated by tumour necrosis factor and nitric oxide blockade

Tassiopoulos, Apostolos K.; Hakim, T. S.; Finck, Christine; Pedoto, Alessia; Hodell, M; Landas, Steve K.; McGraw, Daniel J.

doi:10.1016/s1078-5884(98)80089-0

Cited by 26 publications

(12 citation statements)

References 28 publications

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“…NO then modulates cell migration on a two-dimensional surface as well as cell migration through three-dimensional matrix, as encountered in the extraluminal environment of the vessel or in the soft tissue adjacent to a wound. In a rat model of acute lung injury, NOS blockade led to decreased polymorphic neutrophils (PMN) transmigration (Tassiopoulos et al, 1998). These data are consistent with our finding that NO enhances transendothelial cell migration of monocytes across a stimulated monolayer of endothelial cells.…”

Section: Cellular Responses To Nitric Oxidesupporting

confidence: 90%

Nitric oxide in wound-healing

et al. 2005

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Modulation of the complex process of wound-healing remains a surgical challenge. Little improvement beyond controlling infection, gentle tissue handling, and debridement of necrotic tissue has been had in the modern era. However, increasing appreciation of the process from a biomolecular perspective offers the potential for making significant strides in wound modulation. The bioactive molecule nitric oxide was found to have wide-ranging impact on cellular activities, including the cellular responses engendered by wound healing. Current research suggests that nitric oxide and several nitric oxide donors can exert biologic effects, although the particular net responses of cells contributing to wound repair are context-dependent.

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Section: Cellular Responses To Nitric Oxidesupporting

confidence: 90%

Nitric oxide in wound-healing

et al. 2005

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“…Various reperfusion techniques have been developed to modify or prevent the reperfusion damage, such as the limb washout technique using a roller pump [37], axillo-bifemoral grafting with intermittent perfusion of the lower limbs to control subsequent hyperkalemia [40], or the use of an oxygenator to reperfuse ischemic tissue [48]. In addition, numerous pathophysiological mechanisms and pharmacological treatments have been advocated for the management of reperfusion injury after acute limb ischemia, including steroids, lazaroids, barbiturates, papaverine, pentoxifylline, leukocyte-antibodies and radical scavenger just to mention a few [4,8,10,14,16,[20][21][22]24,32,33,39,44]. However, a stable reperfusion protocol has not evolved and the treatment of ischemiaperfusion of the lower limbs still consists in surgical revascularization, fasciotomy, excision of primary necrotic tissue, increase of urine output with urine alkalinization, treatment of hyperkalemia and, recently, the development of interventional treatment, e.g., for aortic saddle thrombus consisting in angioplasty and streptokinase 1 application [2,25].…”

Section: Discussionmentioning

confidence: 99%

Prevention of postischemic tissue injury by controlled reperfusion: A preliminary study

et al. 2011

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Restoration of arterial blood flow to severely and acutely ischemic extremities results in tissue necrosis and systemic-metabolic complications associated with multiorgan failure and death. Surgical revascularization alone (SRA) was compared with revascularization and controlled reperfusion using standard cardiopulmonary bypass (R-CPB) in 41 patients with acute lower limb ischemia and ischemia-induced neurological dysfunction. The mean ischemia time was 17 ± 10 hours. Eighteen patients (44%) had unilateral femoral artery occlusion, 23 (56%) had distal aortic occlusion. Eleven patients (27%) presented ischemia-induced paraplegia. SRA was performed in 23 patients (56%), and R-CPB in 18 (44%). End-points were hospital mortality, lower limb amputation, the number of surgical fasciotomies, and the incidence of permanent neurological morbidity. Hospital mortality was 19.5%; it was 33% after SRA, and 5.5% with R-CPB (p = 0.007). R-CBP was superior to SRA in terms of amputation rate (0% vs. 21.7%, p = 0.056), number of fasciotomies performed (7% vs. 64%, p = 0.002), and neurological recovery (86% vs. 19%, p = 0.000). After acute lower limb ischemia controlled reperfusion using standard cardiopulmonary bypass techniques preserves skeletal muscle and nerve function and prevents local as well as systemic complications of postischemic restoration of bloodflow.

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“…Peroxynitrite has cytotoxic potential through reactions with protein and non-protein sulphydryls, oxidation of lipids, nitrosation of tyrosine and induction of single-strand breaks in DNA [32,33]. However, studies have also shown that NO may promote the chemotactic potential of neutrophils [34][35][36][37] and stimulate the production of proinflammatory agents [36].…”

Section: Discussionmentioning

confidence: 99%

Effects of a dual endothelin-1 receptor antagonist on airway obstruction and acute lung injury in sheep following smoke inhalation and burn injury

et al. 2005

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Studies have suggested that ET-1 (endothelin-1) is associated with lung injury, airway inflammation and increased vascular permeability. In the present study we have tested the hypothesis that treatment with a dual ET-1 receptor antagonist will decrease airway obstruction and improve pulmonary function in sheep with combined S+B (smoke inhalation and burn) injury. Twelve sheep received S+B injury using the following protocol: six sheep were treated with tezosentan, an ETA and ETB receptor antagonist, and six sheep received an equivalent volume of vehicle. Physiological and morphological variables were assessed during the 48 h study period and at the end of the study. There was no statistically significant difference in the PaO2/FiO2 (partial pressure of O2 in arterial blood/fraction of O2 in the inspired gas) ratio of the tezosentan-treated animals compared with controls; however, lung lymph flow was significantly higher (P<0.05) in the treated animals. PVRI (pulmonary vascular resistance index) was significantly reduced (P<0.05) in the tezosentan-treated animals. Assessment of NOx (nitric oxide metabolite) levels in plasma and lymph showed significantly elevated (P<0.05) levels in the tezosentan-treated animals compared with levels in untreated sheep. The degree of bronchial obstruction was similar in both treated and control sheep; however, bronchiolar obstruction was reduced in sheep treated with tezosentan. Histopathologically, no difference in the degree of parenchymal injury was detected. In conclusion, administration of a dual ET-1 receptor antagonist prevented an increase in PVRI after injury and reduced the degree of bronchiolar obstruction in sheep with S+B; however, treated sheep showed higher levels of NOx and increased lung lymph flow. Tezosentan treatment was ineffective in protecting against acute lung injury in this model.

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Neutrophil sequestration in the lung following acute aortic occlusion starts during ischaemia and can be attenuated by tumour necrosis factor and nitric oxide blockade

Abstract: Acute lung injury resulting from distal aortic occlusion starts during ischaemia. TNF and NO blockade decrease PMN chemotaxis and sequestration and attenuate the lung injury process.

Cited by 26 publications

References 28 publications

Nitric oxide in wound-healing

Nitric oxide in wound-healing

Prevention of postischemic tissue injury by controlled reperfusion: A preliminary study

Effects of a dual endothelin-1 receptor antagonist on airway obstruction and acute lung injury in sheep following smoke inhalation and burn injury

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