Neutrophil PAD4 Expression and Its Pivotal Role in Assessment of Alcohol-Related Liver Disease
Anna Rycyk-Bojarzynska,
Beata Kasztelan-Szczerbinska,
Halina Cichoz-Lach
et al.
Abstract:Neutrophils release neutrophil extracellular traps (NETs) as a defense strategy in response to broad-spectrum infections and sterile triggers. NETs consist of a DNA scaffold decorated with antimicrobial peptides (AMPs) and enzymatically active proteases, including peptidyl arginine deiminase type 4 (PAD4). Susceptibility to infections and inflammatory dysregulation are hallmarks of alcohol-related liver disease (ALD). Sixty-two patients with ALD were prospectively recruited, and they were followed for 90 days.… Show more
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