Neutrophil migration in mice induced by a mannose-binding lectin isolated from Annona coriacea seeds

Coelho, Mirela B.; DeSouza, Ivani A.; Freire, Maria G. M.; Marangoni, Sérgio; Antunes, Edson; Macedo, Maria Lígia Rodrigues

doi:10.1016/j.toxicon.2006.07.001

Cited by 17 publications

(11 citation statements)

References 32 publications

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“…However, we could not discard that the reduction in the rolling and adhesion are also consequence of the interference of LSL on the interaction of leukocytes to endothelium. In fact, several lectin reduce these interaction of leukocytes in vitro and in vivo experiments [55,56]. So, the development of therapies using LSL as prototypes to inhibit neutrophil migration could be an important aim to management inflammatory diseases.…”

Section: Discussionmentioning

confidence: 99%

Lonchocarpus sericeus lectin decreases leukocyte migration and mechanical hypernociception by inhibiting cytokine and chemokines production

Napimoga

Cavada

Alencar

et al. 2007

International Immunopharmacology

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Section: Discussionmentioning

confidence: 99%

Lonchocarpus sericeus lectin decreases leukocyte migration and mechanical hypernociception by inhibiting cytokine and chemokines production

Napimoga

Cavada

Alencar

et al. 2007

International Immunopharmacology

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“…The Annona genus, with 250 species found in the Brazilian territory (Souza & Lorenzi, 2008;MelloSilva & Pontes, 2005), has revealed the presence of different classes of active metabolites, like isoquinoline and pyrimidine-ß-carboline alkaloids (Silva et al, 2007a, Costa et al, 2006, acetogenins (Yang et al, 2009), lectins (Coelho et al, 2003) and volatile oils (Ferreira et al, 2009;Boyom et al, 1996), against the protozoaries responsible for endemic tropical diseases.…”

Section: Introductionmentioning

confidence: 99%

Chemical constituents of the volatile oil from leaves of Annona coriacea and in vitro antiprotozoal activity

Siqueira

Oliani

Sartoratto³

et al. 2011

Rev. bras. farmacogn.

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Abstract:The essential oil of the leaves from Annona coriacea Mart., Annonaceae, was extracted by hydrodistillation in a Clevenger apparatus and analyzed by GC/MS and GC/FID. The oil yield was 0.05% m/m. Sixty compounds were identified, in a complex mixture of sesquiterpenes (76.7%), monoterpenes (20.0%) and other constituents (3.3%). Bicyclogermacrene was its major compound (39.8%) followed by other sesquiterpenes. Most of the monoterpenes were in low concentration (<1%). Only β-pinene and pseudolimonene presented the highest level of 1.6%. The volatile oil presented anti-leishmanial and trypanocidal activity against promastigotes of four species of Leishmania and trypomastigotes of Trypanosoma cruzi, showing to be more active against Leishmania (L.) chagasi (IC50 39.93 µg/mL) (95% CI 28.00-56.95 µg/mL).

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“…HGA demonstrated the ability to agglutinate human erythrocytes with preference for type A treated with papain. Previous studies have shown the ability of some lectins to reduce the rolling and adhesion of neutrophils on the endothelium, possibly by blocking interactions of adhesion molecules present on neutrophils (L-selectins) and endothelial cells (Eand P-selectins) [26,27,57,58]. Marine lectins are generally identified by their metal ion requirement for their hemagglutination activity.…”

Section: Discussionmentioning

confidence: 99%

Holothuria grisea agglutinin (HGA): the first invertebrate lectin with anti‐inflammatory effects

Moura

Aragão

Melo

et al. 2012

Fundamemntal Clinical Pharma

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Holothuria grisea agglutinin (HGA) is a dimeric lectin of molecular mass 228 kDa by gel filtration with monomers of 105 kDa by SDS-PAGE. The lectin is highly thermostable as it retains full activity for 1 h at 70 °C. Unlike other lectins purified from marine invertebrates, the hemagglutination activity of HGA does not require any divalent metal ions. The affinity analysis of HGA showed that only mucin was able to inhibit the hemagglutinating activity. HGA administered intravenously was tested in classical models of nociception and inflammation. HGA was able to inhibit neutrophil migration into the peritoneal cavity induced by carrageenan. This inhibitory effect was 68% at a dose of 1 mg/kg. In acetic acid-induced writhing tests, a significant antinociceptive effect was observed by treatment with HGA (0.1; 1 or 10 mg/kg) reducing constrictions by 27, 90 and 84%, respectively. In formalin tests, HGA at a dose of 10 mg/kg showed antinociceptive effect only in the inflammatory phase (phase 2). Nevertheless, in hot-plate tests, HGA did not show any nociceptive effect. In rota-rod and open-field tests, HGA did not alter the animals' behavior. The treatment with HGA 10 mg/kg presented diminished myeloperoxidase activity activity (81.6% inhibition) and raised the circulating levels of NO by 50.4% when compared with the carrageenan group. HGA has demonstrated the ability to modulate the inflammatory response in models of inflammation in vivo. HGA is the first marine invertebrate lectin that showed an anti-inflammatory effect. This finding opens a new perspective on the potential of lectins from the marine environment.

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Neutrophil migration in mice induced by a mannose-binding lectin isolated from Annona coriacea seeds

Cited by 17 publications

References 32 publications

Lonchocarpus sericeus lectin decreases leukocyte migration and mechanical hypernociception by inhibiting cytokine and chemokines production

Lonchocarpus sericeus lectin decreases leukocyte migration and mechanical hypernociception by inhibiting cytokine and chemokines production

Chemical constituents of the volatile oil from leaves of Annona coriacea and in vitro antiprotozoal activity

Holothuria grisea agglutinin (HGA): the first invertebrate lectin with anti‐inflammatory effects

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