Neutrophil microparticles modulate cytokine production by natural killer cells

Pliyev, Boris K.; Kalintseva, Mariya V.; Abdulaeva, Sofya V.; Yarygin, K. N.; Vg, Savchenko

doi:10.1016/j.cyto.2013.11.010

Cited by 40 publications

(52 citation statements)

References 11 publications

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“…Interestingly, the positive-feedback loop between MVs and inflammation may not be so clear cut, as MVs from patients with sepsis have been shown to enhance aortic contraction in mice and it has been proposed they may play a protective role by reversing the fall in peripheral resistance and hypotension seen in severe sepsis [71] as well as promoting the release of IL-10 [75]. MVs, particularly those derived from granulocytes, have also been noted to have anti-inflammatory properties [75][76][77][78]. Together, these studies suggest that pro-inflammatory cytokines are potent triggers for MV release and the response can be modified with targeted cytokine therapies.…”

Section: Inflammationmentioning

confidence: 96%

Dynamic microvesicle release and clearance within the cardiovascular system: triggers and mechanisms

et al. 2015

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Interest in cell-derived microvesicles (or microparticles) within cardiovascular diagnostics and therapeutics is rapidly growing. Microvesicles are often measured in the circulation at a single time point. However, it is becoming clear that microvesicle levels both increase and decrease rapidly in response to certain stimuli such as hypoxia, acute cardiac stress, shear stress, hypertriglyceridaemia and inflammation. Consequently, the levels of circulating microvesicles will reflect the balance between dynamic mechanisms for release and clearance. The present review describes the range of triggers currently known to lead to microvesicle release from different cellular origins into the circulation. Specifically, the published data are used to summarize the dynamic impact of these triggers on the degree and rate of microvesicle release. Secondly, a summary of the current understanding of microvesicle clearance via different cellular systems, including the endothelial cell and macrophage, is presented, based on reported studies of clearance in experimental models and clinical scenarios, such as transfusion or cardiac stress. Together, this information can be used to provide insights into potential underlying biological mechanisms that might explain the increases or decreases in circulating microvesicle levels that have been reported and help to design future clinical studies.

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Section: Inflammationmentioning

confidence: 96%

Dynamic microvesicle release and clearance within the cardiovascular system: triggers and mechanisms

et al. 2015

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“…In addition, NDMVs from both apoptotic and zymogen stimulated neutrophils cause macrophages to generate distinct lipid pro-resolving mediators [39], which would also serve to contribute to a counter inflammatory response. Alterations in TGF-β1 production have been observed after incubation with NDMVs [26e, 40]. TGF-β1 can enhance regulatory T-Cell differentiation [41], as well as block macrophage and lymphocyte activation.…”

Section: Numbers Of Ndmv Are Increased In Disease Statesmentioning

confidence: 99%

“…TGF-β1 can enhance regulatory T-Cell differentiation [41], as well as block macrophage and lymphocyte activation. More recently, NDMVs have been shown to decrease production of IFN-γ and TNF-α, while increasing release of TGF-β1in IL-2 activated natural killer cells [40b]. …”

Section: Numbers Of Ndmv Are Increased In Disease Statesmentioning

confidence: 99%

Neutrophil Derived Microvesicles: Emerging Role of a Key Mediator to the Immune Response

Johnson¹,

III²,

Kuethe³

et al. 2014

EMIDDT

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In response to infection and trauma, exquisite control of the innate inflammatory response is necessary to promote an anti-microbial response and minimize tissue injury. Over the course of the host response, activated leukocytes are essential for the initial response and can later become unresponsive or undergo apoptosis. Leukocytes, along the continuum of activation to apoptosis, have been shown to generate microvesicles. These vesicles can range in size from 0.1 to 1.0 µm and can retain proteins, RNA and DNA of their parent cells. Importantly, neutrophil-derived microvesicles (NDMV) are robustly increased under inflammatory conditions. The aim of this review is to summarize the research to date upon NDMVs. This will include describing under which disease states NDMVs are increased, mechanisms underlying formation, and the impact of these vesicles upon cellular targets. Altogether, increased awareness of NDMVs during the host innate response may allow for diagnostic tools as well as potential novel therapies during infection and trauma.

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“…3,50 In addition, recent observations suggest that, by releasing EVs, neutrophils negatively modulate NK cell functions, in particular skewing NK-derived cytokines from a proinflammatory to an antiinflammatory profile. 51 The relevance of the in vitro findings on cross-talk between human neutrophils and NK cells has been highlighted by studies proving that, under steady state, neutrophils are crucial for NK-cell development in both humans and mice. 52 Additional evidence that cross-talk between these 2 cell types can also occur in vivo has recently been shown in a mouse model of systemic fungal infection, in which an IL-17-NK cell-GM-CSF axis was found to be critical for the modulation of neutrophil fungicidal activity.…”

Section: Cross-talk Between Neutrophils and Innate Immune Cellsmentioning

confidence: 99%

Social networking of human neutrophils within the immune system

Scapini

Cassatella

2014

Blood

349

320

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It is now widely recognized that neutrophils are highly versatile and sophisticated cells that display de novo synthetic capacity and may greatly extend their lifespan. In addition, concepts such as “neutrophil heterogeneity” and “neutrophil plasticity” have started to emerge, implying that, under pathological conditions, neutrophils may differentiate into discrete subsets defined by distinct phenotypic and functional profiles. A number of studies have shown that neutrophils act as effectors in both innate and adaptive immunoregulatory networks. In fact, once recruited into inflamed tissues, neutrophils engage into complex bidirectional interactions with macrophages, natural killer, dendritic and mesenchymal stem cells, B and T lymphocytes, or platelets. As a result of this cross-talk, mediated either by contact-dependent mechanisms or cell-derived soluble factors, neutrophils and target cells reciprocally modulate their survival and activation status. Altogether, these novel aspects of neutrophil biology have shed new light not only on the potential complex roles that neutrophils play during inflammation and immune responses, but also in the pathogenesis of several inflammatory disorders including infection, autoimmunity, and cancer.

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Neutrophil microparticles modulate cytokine production by natural killer cells

Cited by 40 publications

References 11 publications

Dynamic microvesicle release and clearance within the cardiovascular system: triggers and mechanisms

Dynamic microvesicle release and clearance within the cardiovascular system: triggers and mechanisms

Neutrophil Derived Microvesicles: Emerging Role of a Key Mediator to the Immune Response

Social networking of human neutrophils within the immune system

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