Neutrophil membrane-coated nanoparticles for enhanced nanosecond pulsed electric field treatment of pancreatic cancer

Zhao, Jingbo; Lu, Huidan; Xu, Dongyu; Sun, Ruiqi; Fang, Chengyu; Zhao, Qiyu; He, Chang; Pan, Yuwei; Xu, Feng

doi:10.1080/02656736.2022.2093994

Cited by 11 publications

(8 citation statements)

References 47 publications

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“…Though, approaches that would target particular neutrophil subpopulation remain limited and warrant additional investigation. Presently, some neutrophil‐targeted nanoparticles and nanoformulations targeting specific neutrophil subpopulations have shown favorable alleviative effects 362,363 . This may be due to innate ability possessed by cells to sense, integrate and respond to the dynamic environment within the body, rendering them suitable as carriers of therapeutic drugs.…”

Section: Discussionmentioning

confidence: 99%

The double‐edged role of neutrophil heterogeneity in inflammatory diseases and cancers

Zhou

Cao

et al. 2023

MedComm

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Neutrophils are important immune cells act as the body's first line of defense against infection and respond to diverse inflammatory cues. Many studies have demonstrated that neutrophils display plasticity in inflammatory diseases and cancers. Clarifying the role of neutrophil heterogeneity in inflammatory diseases and cancers will contribute to the development of novel treatment strategies. In this review, we have presented a review on the development of the understanding on neutrophil heterogeneity from the traditional perspective and a high‐resolution viewpoint. A growing body of evidence has confirmed the double‐edged role of neutrophils in inflammatory diseases and tumors. This may be due to a lack of precise understanding of the role of specific neutrophil subsets in the disease. Thus, elucidating specific neutrophil subsets involved in diseases would benefit the development of precision medicine. Thusly, we have summarized the relevance and actions of neutrophil heterogeneity in inflammatory diseases and cancers comprehensively. Meanwhile, we also discussed the potential intervention strategy for neutrophils. This review is intended to deepen our understanding of neutrophil heterogeneity in inflammatory diseases and cancers, while hold promise for precise treatment of neutrophil‐related diseases.

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Section: Discussionmentioning

confidence: 99%

The double‐edged role of neutrophil heterogeneity in inflammatory diseases and cancers

Zhou

Cao

et al. 2023

MedComm

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“…PLTm@NPs Breast cancer [40][41][42] Colon cancer [42,43] Liver cancer [44] Nm@NPs Breast cancer [7,28] Liver cancer [45] Pancreatic cancer [46,47] Mm@NPs Breast cancer [48][49][50] Osteosarcoma [51] Glioma [52] Tm@NPs Melanoma [53,54] Liver cancer [55] Glioma [56] Lymphoma [57] DCm@NPs Melanoma [58,59] Breast cancer [60,61] Liver cancer [62] Glioma [63] NKm@NPs Breast cancer [64] Liver cancer [65] Glioma [66,67] SCm@NPs Liver cancer [68] Bone cancer [69] Prostate cancer [70] CCm@NPs Melanoma [71][72][73] Cervical cancer [74,75] Breast cancer [76,77] Colon cancer [78] Osteosarcoma [79,80] Colorectal cancer [81] Oral squamous cell carcinoma [82] Bladder cancer [83]...…”

Section: Type Of Cmc@nps Cancer Models Referencesmentioning

confidence: 99%

Cell Membrane-Coated Biomimetic Nanoparticles in Cancer Treatment

Zhang,

Gao

et al. 2024

Pharmaceutics

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Nanoparticle-based drug delivery systems hold promise for cancer treatment by enhancing the solubility and stability of anti-tumor drugs. Nonetheless, the challenges of inadequate targeting and limited biocompatibility persist. In recent years, cell membrane nano-biomimetic drug delivery systems have emerged as a focal point of research and development, due to their exceptional traits, including precise targeting, low toxicity, and good biocompatibility. This review outlines the categorization and advantages of cell membrane bionic nano-delivery systems, provides an introduction to preparation methods, and assesses their applications in cancer treatment, including chemotherapy, gene therapy, immunotherapy, photodynamic therapy, photothermal therapy, and combination therapy. Notably, the review delves into the challenges in the application of various cell membrane bionic nano-delivery systems and identifies opportunities for future advancement. Embracing cell membrane-coated biomimetic nanoparticles presents a novel and unparalleled avenue for personalized tumor therapy.

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“…The nanocarriers have the ability to impede the growth and spread of tumors both in laboratory settings and in living organisms, as well as trigger programmed cell death in early-stage tumor cells and CTCs ( 97 ). Furthermore, NE membrane–bound liposomes have been employed for precise medication administration in the context of pancreatic cancer ( Figure 7B ) ( 117 ).…”

Section: Membrane Biomimetic Nanoparticlesmentioning

confidence: 99%

Research progress of cell membrane biomimetic nanoparticles for circulating tumor cells

Zhang,

Wang

2024

Front. Oncol.

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Early detection of cancer is crucial to reducing fatalities and improving patient outcomes. Metastasis is the first stage of aggressive cancers, often occurring before primary lesions can be seen. It occurs when cancerous cells disseminate to distant, non-malignant organs through the bloodstream, known as circulating tumor cells (CTCs). CTCs, or cancer tumor cells, are valuable indicators for predicting treatment response, metastasis progression, and disease progression. However, they are primarily used for research due to challenges like heterogeneity, separation from blood, and lack of clinical validation. Only a few methods have been approved for clinical use. One area of research is the isolation and identification of CTCs, which could significantly impact early cancer detection and prognosis. Current technologies using whole-blood samples use size, immunoaffinity, and density approaches, along with positive and negative enrichment techniques. Surface modification of nanomaterials is important for effective cancer therapies because it improves their ability to target and reduces interactions with healthy tissues. Consequently, researchers have created biomimetic nanoparticles covered with cell membranes using functional, targeted, and biocompatible coating technology. Nanoparticles with membranes can target specific cells, stay in circulation for longer, and avoid immune responses, which makes them much better at capturing CTCs. This study examines the current opportunities and difficulties associated with using cell membrane–coated nanoparticles as a capture technique for CTCs. In addition, we examine potential future developments in light of the current obstacles and investigate areas that require further research to fully understand its growing clinical possibilities.

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Neutrophil membrane-coated nanoparticles for enhanced nanosecond pulsed electric field treatment of pancreatic cancer

Cited by 11 publications

References 47 publications

The double‐edged role of neutrophil heterogeneity in inflammatory diseases and cancers

The double‐edged role of neutrophil heterogeneity in inflammatory diseases and cancers

Cell Membrane-Coated Biomimetic Nanoparticles in Cancer Treatment

Research progress of cell membrane biomimetic nanoparticles for circulating tumor cells

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