Neutrophil mediated drug delivery for targeted glioblastoma therapy: A comprehensive review

Neutrophil hitchhiking: Riding the drug delivery wave to treat diseases

“…Cancer cells exploit neutrophils to release NETs into the tumor microenvironment (Que et al, 2022). Mirzaei et al have concluded that neutrophils can mediate drug delivery targeting glioblastoma therapy (Hosseinalizadeh et al, 2022). While NETs are instrumental in the defense against infections, they also play a significant role in the development of various noncommunicable diseases, including cancer.…”

“…NETs are intricate structures consisting of dense nuclear or mitochondrial DNA decorated with numerous granules and cytoplasmic proteins. Cancer cells exploit neutrophils to release NETs into the tumor microenvironment(Que et al, 2022).Mirzaei et al have concluded that neutrophils can mediate drug delivery targeting glioblastoma therapy(Hosseinalizadeh et al, 2022).While NETs are instrumental in the defense against infections, they also play a significant role in the development of various noncommunicable diseases, including cancer. The role of NETs in tumor development extends to cancer immune editing and the interactions between the immune system and cancer cells.…”

Recent advances in targeted drug delivery for the treatment of glioblastoma

“…2 Characteristics of the TME, including low pH, redox, overexpressed enzymes, hypoxia, overexpressed ATP and an immunosuppressive microenvironment. 38 Nanoscale Review cell types have been used in recent studies for GBM therapy, including stem cells, [54][55][56][57] red blood cells (RBCs), 58 macrophages, 59 neutrophils (NEs), 60 T cells 61,62 and so on. The following studies are representative examples of the role of these types as drug carriers in the GBM model.…”

Platelet membrane-based biochemotactic-targeting nanoplatform combining PDT with EGFR inhibition therapy for the treatment of breast cancer

“…Breast cancer is the most common cancer worldwide, accounting for one in eight of all cancer diagnoses and is the second leading cause of cancer death in women. Statistics show that female deaths caused by breast cancer account for about 15.5% of all cancer deaths, and therefore breast cancer has aroused widespread concern as a threat to women and their health worldwide. 1,2 Despite significant improvements in overall survival rates due to advances in diagnosis, prevention, and treatment, breast cancer still kills hundreds of thousands of people each year.…”

“…12,13 For instance, utilizing the biological chemotactic effect of neutrophils on inflammation, researchers have constructed various neutrophil cell membrane-camouflaged nano-targeted drug delivery systems. [14][15][16] Zhang et al successfully used neutrophil-carried paclitaxel liposomes to traverse the BBB/BBTB, finally resulting in the suppression of postoperative malignant glioma recurrence. 17 Similarly, Wang et al also developed a neutrophil exosome (NEs-Exos) drug delivery system, which was successfully used for glioma treatment.…”