Neutrophil-mediated and low density lipoprotein receptor-mediated dual-targeting nanoformulation enhances brain accumulation of scutellarin and exerts neuroprotective effects against ischemic stroke

Dang, Yanxin; An, Chiying; Li, Yutao; Han, Dongdong; Liu, Xin; Zhang, Feng‐Ming; Xu, Yuan; Zhong, Hai‐Jing; Khan, Mewand Khan Karim; Zou, Fengjuan; Sun, Xiaojun

doi:10.1039/c8ra06688d

Cited by 15 publications

(6 citation statements)

References 51 publications

(77 reference statements)

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“…Nanomaterials decorated with Angiopep-2 have also been utilized for treatment of ischemic stroke and epilepsy, among other ailments. 45,47,48…”

Section: Peptidesmentioning

confidence: 99%

“…Nanomaterials decorated with Angiopep-2 have also been utilized for treatment of ischemic stroke and epilepsy, among other ailments. 45,47,48 As an alternative to peptides that permeate the BBB through receptor-mediated transcytosis, cell-penetrating peptides (CPPs) penetrate the BBB through adsorptive-mediated transcytosis. 49 CPPs are typically highly positively charged and interact strongly with negatively charged cell surfaces, inducing transcytosis even at the highly restrictive BBB.…”

Section: Peptidesmentioning

confidence: 99%

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Biomacromolecule-tagged nanoscale constructs for crossing the blood–brain barrier

Odom,

LeBroc,

Callmann

2024

Nanoscale

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“…Nanomaterials decorated with Angiopep-2 have also been utilized for treatment of ischemic stroke and epilepsy, among other ailments. 45,47,48…”

Section: Peptidesmentioning

confidence: 99%

Section: Peptidesmentioning

confidence: 99%

Biomacromolecule-tagged nanoscale constructs for crossing the blood–brain barrier

Odom,

LeBroc,

Callmann

2024

Nanoscale

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“…Attributed to the receptor-mediated tropism and integrin-mediated adhesion, neutrophil membrane confers nanoparticles with homotypic targeting capacity and stability in blood circulation. Intriguingly, superficial modification mechanisms based on artificial neutrophil-related ligands were utilized in recent advances [ 105 , 106 ]. The neutrophil-homing ligands (such as Mac-1 and LFA-1) drove the interaction with inflamed microvascular endothelial cells and lured DDS to damaged brain.…”

Section: Cell Membrane-based Nanoparticles For Is Treatmentmentioning

confidence: 99%

Biomimetic nanoparticles in ischemic stroke therapy

Liu

Xiao

et al. 2023

Discover Nano

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Ischemic stroke is one of the most severe neurological disorders with limited therapeutic strategies. The utilization of nanoparticle drug delivery systems is a burgeoning field and has been widely investigated. Among these, biomimetic drug delivery systems composed of biogenic membrane components and synthetic nanoparticles have been extensively highlighted in recent years. Biomimetic membrane camouflage presents an effective strategy to prolong circulation, reduce immunogenicity and enhance targeting. For one thing, biomimetic nanoparticles reserve the physical and chemical properties of intrinsic nanoparticle. For another, the biological functions of original source cells are completely inherited. Compared to conventional surface modification methods, this approach is more convenient and biocompatible. In this review, membrane-based nanoparticles derived from different donor cells were exemplified. The prospect of future biomimetic nanoparticles in ischemic stroke therapy was discussed. Graphic abstract

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“…This system enhances the resolution of inflammation during ischemic stroke therapy. In addition, recent studies have utilized surface modification mechanisms based on neutrophil-associated ligands, offering promising prospects for targeted treatment of brain diseases [ 57 , 58 ].…”

Section: Characterization Of the Cell Membranementioning

confidence: 99%

Cell Membrane-Derived Nanovehicles for Targeted Therapy of Ischemic Stroke: From Construction to Application

Hao,

Sha,

et al. 2023

Pharmaceutics

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Ischemic stroke (IS) is a prevalent form of stroke and a leading cause of mortality and disability. Recently, cell membrane-derived nanovehicles (CMNVs) derived from erythrocytes, thrombocytes, neutrophils, macrophages, neural stem cells, and cancer cells have shown great promise as drug delivery systems for IS treatment. By precisely controlling drug release rates and targeting specific sites in the brain, CMNVs enable the reduction in drug dosage and minimization of side effects, thus significantly enhancing therapeutic strategies and approaches for IS. While there are some reviews regarding the applications of CMNVs in the treatment of IS, there has been limited attention given to important aspects such as carrier construction, structural design, and functional modification. Therefore, this review aims to address these key issues in CMNVs preparation, structural composition, modification, and other relevant aspects, with a specific focus on targeted therapy for IS. Finally, the challenges and prospects in this field are discussed.

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Neutrophil-mediated and low density lipoprotein receptor-mediated dual-targeting nanoformulation enhances brain accumulation of scutellarin and exerts neuroprotective effects against ischemic stroke

Abstract: Delivery of poorly permeable drugs across the blood-brain barrier (BBB) is a great challenge in the treatment of ischemic stroke.

Cited by 15 publications

References 51 publications

Biomacromolecule-tagged nanoscale constructs for crossing the blood–brain barrier

Biomacromolecule-tagged nanoscale constructs for crossing the blood–brain barrier

Biomimetic nanoparticles in ischemic stroke therapy

Cell Membrane-Derived Nanovehicles for Targeted Therapy of Ischemic Stroke: From Construction to Application

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