Neutrophil-lymphocyte ratios as inflammatory biomarkers in psychiatric patients

Bhikram, Tracy; Sandor, Paul

doi:10.1016/j.bbi.2022.07.006

Cited by 41 publications

(26 citation statements)

References 109 publications

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“…The results of studies on lymphocyte counts in patients with schizophrenia are not yet consistent. Some studies suggested that patients with schizophrenia exhibit a blood cell pattern of increased neutrophils, decreased lymphocytes, and increased neutrophil to lymphocyte ratio [35,36]. However, there is evidence indicating that pro-in ammatory-prone monocytes were signi cantly overrepresented and the T-lymphocyte network was signi cantly activated in patients with recurrentonset schizophrenia [37].…”

Section: Discussionmentioning

confidence: 99%

The association between schizophrenia and white blood cells count: a bidirectional two-sample Mendelian randomization study

Gao

Guo

et al. 2022

Preprint

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Background. Positive associations between the risk of schizophrenia and white blood cells (WBC) counts, have been suggested by observational studies. However, the causality of this association is still unclear. Methods. We used a group of bidirectional two-sample Mendelian randomization (MR) analyses to estimate the causal relationship between schizophrenia and WBC count traits (i.e., WBC count, lymphocyte count, neutrophil count, basophil count, eosinophil count, and monocyte count). In total, 81, 95, 85, 87, 76, 83 schizophrenia-related single nucleotide polymorphisms (SNPs) were used as genetic instruments from Psychiatric Genomics Consortium for six WBC count traits, respectively. And in reverse MR analysis, 458, 206, 408, 468, 473, 390 variants extracted from six WBC count traits were utilized as genetic instruments, which were obtained from a recent large-scale Genome-Wide Association Study (GWAS). Results. Genetically predicted schizophrenia was positively associated with the risk of WBC count [odds ratio (OR) 1.017, 95% confidence interval (CI) 1.008–1.026; P = 7.53×10− 4], basophil count (OR 1.014, 95%CI 1.005–1.022; P = 0.002), eosinophil count (OR 1.021, 95%CI 1.011–1.031; P = 2.77×10− 4), monocyte count(OR 1.018, 95%CI 1.009–1.027; P = 4.60×10− 4), lymphocyte count(OR 1.021, 95%CI 1.012–1.030; P = 4.51×10− 5), and neutrophil count (OR 1.013, 95%CI 1.005–1.022; P = 0.004). WBC count traits are not associated with the risk of schizophrenia in our reverse MR results. Conclusion. Schizophrenia is associated with increased risk of WBC count (i.e., high WBC count, lymphocyte count, neutrophil count, basophil count, eosinophil count, and monocyte count).

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Section: Discussionmentioning

confidence: 99%

The association between schizophrenia and white blood cells count: a bidirectional two-sample Mendelian randomization study

Gao

Guo

et al. 2022

Preprint

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“…Indeed, the clinical efficacy of immunomodulation, though currently recommended for the treatment of PANDAS/PANS, 6 remains suboptimal. 7 One proposed marker of heightened inflammatory responses is an increased neutrophil-lymphocyte ratio (NLR), 8 which rather than being illness-specific, is a broad indication of mostly innate immune activation that occurs in both infective 9 and non-infective 10 conditions. Although widely investigated in conditions not related to the central nervous system, 11 increased NLR values have also been observed in neuropsychiatric cohorts, e.g.…”

Section: Introductionmentioning

confidence: 99%

“…Although widely investigated in conditions not related to the central nervous system, 11 increased NLR values have also been observed in neuropsychiatric cohorts, e.g. patients suffering from schizophrenia, bipolar disorder, major depressive disorder, 8 and OCD. 12 While increased NLR values do not associate with specific conditionsper se , manipulations of the NLR in animal model systems might be informative for an understanding of how innate and acquired immune components may interact to modulate the expression of specific behavioural phenotypes.…”

Section: Introductionmentioning

confidence: 99%

Dose-, time-, and sex-dependent effects of pegfilgrastim on the neutrophil-lymphocyte ratio in deer mice (Peromyscus maniculatus bairdii)

Strydom

Brand

Viljoen

et al. 2023

Preprint

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An increasing body of research implicates inflammatory processes, including alterations in the neutrophil-lymphocyte ratio (NLR), in the pathophysiology of psychiatric illness. The deer mouse (Peromyscus maniculatus bairdii) is commonly studied for its naturalistic expression of compulsive-like behaviour. Towards future efforts to gain an understanding of how innate and adaptive immune processes might be involved this model, we set out to study the effects of pegfilgrastim, a pegylated recombinant human granulocyte colony-stimulating factor (g-CSF) analogue, on the NLR of both male and female deer mice. Briefly, 54 deer mice (equally distributed between sexes) were exposed to a single injection with either control or pegfilgrastim (0.1 or 1 mg/kg) (n = 18 per group). Six mice of each group were euthanized on days two, four and seven post-administration, blood collected and the NLR calculated. Our results showed that irrespective of dose, pegfilgrastim resulted in higher NLR values in mice of both sexes at days four and seven of testing, but that female mice exposed to the higher dose, presented with significantly higher NLR values irrespective of time, compared to male mice exposed to the same. These data highlight important dose and sex-specific areas for consideration and provide a useful basis for further study of both immunological and brain-immune crosstalk processes in deer mice.

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“…One proposed marker of heightened inflammatory responses is an increased neutrophil-lymphocyte ratio (NLR) [8] which rather than being illness-specific, is a broad indication of mostly innate immune activation that occurs in both infective [9] and non-infective [10] conditions. Although widely investigated in conditions not related to the central nervous system [11], increased NLR values have also been observed in neuropsychiatric cohorts, e.g.…”

Section: Introductionmentioning

confidence: 99%

“…Although widely investigated in conditions not related to the central nervous system [11], increased NLR values have also been observed in neuropsychiatric cohorts, e.g. patients suffering from schizophrenia, bipolar disorder, major depressive disorder [8], and OCD [12].…”

Section: Introductionmentioning

confidence: 99%

Dose-, time-, and sex-dependent effects of pegfilgrastim on the neutrophil-lymphocyte ratio in deer mice (Peromyscus maniculatus bairdii)

Wolmarans

Strydom

Brand

et al. 2023

Preprint

View full text Add to dashboard Cite

An increasing body of research implicates inflammatory processes, including alterations in the neutrophil-lymphocyte ratio (NLR), in the pathophysiology of psychiatric illness. The deer mouse (Peromyscus maniculatus bairdii) is commonly studied for its naturalistic expression of compulsive-like behaviour. Towards future efforts to gain an understanding of how innate and adaptive immune processes might be involved this model, we set out to study the effects of pegfilgrastim, a pegylated recombinant human granulocyte colony-stimulating factor (g-CSF) analogue, on the NLR of both male and female deer mice. Briefly, 54 deer mice (equally distributed between sexes) were exposed to a single injection with either control or pegfilgrastim (0.1 or 1 mg/kg) ( n = 18 per group). Six mice of each group were euthanized on days two, four and seven post-administration, blood collected and the NLR calculated. Our results showed that irrespective of dose, pegfilgrastim resulted in higher NLR values in mice of both sexes at days four and seven of testing, but that female mice exposed to the higher dose, presented with significantly higher NLR values irrespective of time, compared to male mice exposed to the same. These data highlight important dose and sex-specific areas for consideration and provide a useful basis for further study of both immunological and brain-immune crosstalk processes in deer mice.

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Neutrophil-lymphocyte ratios as inflammatory biomarkers in psychiatric patients

Cited by 41 publications

References 109 publications

The association between schizophrenia and white blood cells count: a bidirectional two-sample Mendelian randomization study

The association between schizophrenia and white blood cells count: a bidirectional two-sample Mendelian randomization study

Dose-, time-, and sex-dependent effects of pegfilgrastim on the neutrophil-lymphocyte ratio in deer mice (Peromyscus maniculatus bairdii)

Dose-, time-, and sex-dependent effects of pegfilgrastim on the neutrophil-lymphocyte ratio in deer mice (Peromyscus maniculatus bairdii)

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